Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients
Abstract A better understanding of schizophrenia subtypes is necessary to stratify the patients according to clinical attributes. To explore the genomic architecture of schizophrenia symptomatology, we analyzed blood co-expression modules and their association with clinical data from patients in rem...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-04-01
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| Series: | npj Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-022-00215-1 |
| _version_ | 1797421574902513664 |
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| author | Natalia Rodríguez Patricia Gassó Albert Martínez-Pinteño Àlex-González Segura Gisela Mezquida Lucia Moreno-Izco Javier González-Peñas Iñaki Zorrilla Marta Martin Roberto Rodriguez-Jimenez Iluminada Corripio Salvador Sarró Angela Ibáñez Anna Butjosa Fernando Contreras Miquel Bioque Manuel-Jesús Cuesta Mara Parellada Ana González-Pinto Esther Berrocoso Miquel Bernardo Sergi Mas 2EPS group |
| author_facet | Natalia Rodríguez Patricia Gassó Albert Martínez-Pinteño Àlex-González Segura Gisela Mezquida Lucia Moreno-Izco Javier González-Peñas Iñaki Zorrilla Marta Martin Roberto Rodriguez-Jimenez Iluminada Corripio Salvador Sarró Angela Ibáñez Anna Butjosa Fernando Contreras Miquel Bioque Manuel-Jesús Cuesta Mara Parellada Ana González-Pinto Esther Berrocoso Miquel Bernardo Sergi Mas 2EPS group |
| author_sort | Natalia Rodríguez |
| collection | DOAJ |
| description | Abstract A better understanding of schizophrenia subtypes is necessary to stratify the patients according to clinical attributes. To explore the genomic architecture of schizophrenia symptomatology, we analyzed blood co-expression modules and their association with clinical data from patients in remission after a first episode of schizophrenia. In total, 91 participants of the 2EPS project were included. Gene expression was assessed using the Clariom S Human Array. Weighted-gene co-expression network analysis (WGCNA) was applied to identify modules of co-expressed genes and to test its correlation with global functioning, clinical symptomatology, and premorbid adjustment. Among the 25 modules identified, six modules were significantly correlated with clinical data. These modules could be clustered in two groups according to their correlation with clinical data. Hub genes in each group showing overlap with risk genes for schizophrenia were enriched in biological processes related to metabolic processes, regulation of gene expression, cellular localization and protein transport, immune processes, and neurotrophin pathways. Our results indicate that modules with significant associations with clinical data showed overlap with gene sets previously identified in differential gene-expression analysis in brain, indicating that peripheral tissues could reveal pathogenic mechanisms. Hub genes involved in these modules revealed multiple signaling pathways previously related to schizophrenia, which may represent the complex interplay in the pathological mechanisms behind the disease. These genes could represent potential targets for the development of peripheral biomarkers underlying illness traits in clinical remission stages after a first episode of schizophrenia. |
| first_indexed | 2024-03-09T07:19:30Z |
| format | Article |
| id | doaj.art-ff6cd5c9e1aa4f43abd0d34b246239df |
| institution | Directory Open Access Journal |
| issn | 2334-265X |
| language | English |
| last_indexed | 2024-03-09T07:19:30Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Schizophrenia |
| spelling | doaj.art-ff6cd5c9e1aa4f43abd0d34b246239df2023-12-03T07:53:37ZengNature Portfolionpj Schizophrenia2334-265X2022-04-01811910.1038/s41537-022-00215-1Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patientsNatalia Rodríguez0Patricia Gassó1Albert Martínez-Pinteño2Àlex-González Segura3Gisela Mezquida4Lucia Moreno-Izco5Javier González-Peñas6Iñaki Zorrilla7Marta Martin8Roberto Rodriguez-Jimenez9Iluminada Corripio10Salvador Sarró11Angela Ibáñez12Anna Butjosa13Fernando Contreras14Miquel Bioque15Manuel-Jesús Cuesta16Mara Parellada17Ana González-Pinto18Esther Berrocoso19Miquel Bernardo20Sergi Mas212EPS groupDepartment of Clinical Foundations, Pharmacology Unit, University of BarcelonaDepartment of Clinical Foundations, Pharmacology Unit, University of BarcelonaDepartment of Clinical Foundations, Pharmacology Unit, University of BarcelonaDepartment of Clinical Foundations, Pharmacology Unit, University of BarcelonaDepartment of Clinical Foundations, Pharmacology Unit, University of BarcelonaDepartment of Psychiatry, Complejo Hospitalario de NavarraDepartment of Psychiatry, Complejo Hospitalario de NavarraCentro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)Bellvitge Biomedical Research Institute IDIBELL, Department of Psychiatry, Bellvitge University Hospital, Hospitalet de Llobregat- BarcelonaInstitut d’investigacions Biomèdiques August Pi i Sunyer (IDIBAPs)IdiSNA, Navarra Institute for Health ResearchDepartment of Psychiatry, Complejo Hospitalario de NavarraDepartment of Psychiatry, Complejo Hospitalario de NavarraNeuropsychopharmacology and Psychobiology Research Group, Department of Psychology, University of CádizInstitut d’investigacions Biomèdiques August Pi i Sunyer (IDIBAPs)Department of Clinical Foundations, Pharmacology Unit, University of BarcelonaAbstract A better understanding of schizophrenia subtypes is necessary to stratify the patients according to clinical attributes. To explore the genomic architecture of schizophrenia symptomatology, we analyzed blood co-expression modules and their association with clinical data from patients in remission after a first episode of schizophrenia. In total, 91 participants of the 2EPS project were included. Gene expression was assessed using the Clariom S Human Array. Weighted-gene co-expression network analysis (WGCNA) was applied to identify modules of co-expressed genes and to test its correlation with global functioning, clinical symptomatology, and premorbid adjustment. Among the 25 modules identified, six modules were significantly correlated with clinical data. These modules could be clustered in two groups according to their correlation with clinical data. Hub genes in each group showing overlap with risk genes for schizophrenia were enriched in biological processes related to metabolic processes, regulation of gene expression, cellular localization and protein transport, immune processes, and neurotrophin pathways. Our results indicate that modules with significant associations with clinical data showed overlap with gene sets previously identified in differential gene-expression analysis in brain, indicating that peripheral tissues could reveal pathogenic mechanisms. Hub genes involved in these modules revealed multiple signaling pathways previously related to schizophrenia, which may represent the complex interplay in the pathological mechanisms behind the disease. These genes could represent potential targets for the development of peripheral biomarkers underlying illness traits in clinical remission stages after a first episode of schizophrenia.https://doi.org/10.1038/s41537-022-00215-1 |
| spellingShingle | Natalia Rodríguez Patricia Gassó Albert Martínez-Pinteño Àlex-González Segura Gisela Mezquida Lucia Moreno-Izco Javier González-Peñas Iñaki Zorrilla Marta Martin Roberto Rodriguez-Jimenez Iluminada Corripio Salvador Sarró Angela Ibáñez Anna Butjosa Fernando Contreras Miquel Bioque Manuel-Jesús Cuesta Mara Parellada Ana González-Pinto Esther Berrocoso Miquel Bernardo Sergi Mas 2EPS group Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients npj Schizophrenia |
| title | Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients |
| title_full | Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients |
| title_fullStr | Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients |
| title_full_unstemmed | Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients |
| title_short | Gene co-expression architecture in peripheral blood in a cohort of remitted first-episode schizophrenia patients |
| title_sort | gene co expression architecture in peripheral blood in a cohort of remitted first episode schizophrenia patients |
| url | https://doi.org/10.1038/s41537-022-00215-1 |
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