Optimizing peripheral blood stem cells transplantation outcome through amend relapse and graft failure: a review of current literature
Abstract Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been considered as a valuable approach in treatment of numerous malignant and none malignant hematologic disorders. However, relapse and poor graft function (PGF) after allo-SCT remain to be controversial issues which may af...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-08-01
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| Series: | Experimental Hematology & Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40164-017-0082-5 |
| _version_ | 1811226858440622080 |
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| author | Saeed Mohammadi Amir Hossein Norooznezhad Ashraf Malek Mohammadi Hajar Nasiri Mohsen Nikbakht Najmaldin Saki Mohammad Vaezi Kamran Alimoghaddam Ardeshir Ghavamzadeh |
| author_facet | Saeed Mohammadi Amir Hossein Norooznezhad Ashraf Malek Mohammadi Hajar Nasiri Mohsen Nikbakht Najmaldin Saki Mohammad Vaezi Kamran Alimoghaddam Ardeshir Ghavamzadeh |
| author_sort | Saeed Mohammadi |
| collection | DOAJ |
| description | Abstract Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been considered as a valuable approach in treatment of numerous malignant and none malignant hematologic disorders. However, relapse and poor graft function (PGF) after allo-SCT remain to be controversial issues which may affect the transplantation outcome. Relevant articles were searched in MEDLINE database (2000–2016) using keywords and phrases: donor lymphocyte infusions, allogeneic stem cells transplantation, relapsed hematologic malignancies, booster schedules, cell dose, laboratory monitoring protocols and technical aspects of apheresis. Relapse of disease and PGF could be reduced via noting some main points such as choosing the suitable time and patient for donor lymphocyte infusion (DLI) and also determination of patients who ought to candidate for second allogeneic HSCT or for the use of stem cell boost. DLI and stem cell booster are promising treatment strategies noted in this review. Finally, this paper discusses indications and technical aspects of DLI and stem cell booster in hematological malignancies and emphasizes their therapeutic or pre-emptive potentials. |
| first_indexed | 2024-04-12T09:31:56Z |
| format | Article |
| id | doaj.art-ff6e17c1b5614e6e8073cdcdfe999925 |
| institution | Directory Open Access Journal |
| issn | 2162-3619 |
| language | English |
| last_indexed | 2024-04-12T09:31:56Z |
| publishDate | 2017-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Experimental Hematology & Oncology |
| spelling | doaj.art-ff6e17c1b5614e6e8073cdcdfe9999252022-12-22T03:38:20ZengBMCExperimental Hematology & Oncology2162-36192017-08-016111110.1186/s40164-017-0082-5Optimizing peripheral blood stem cells transplantation outcome through amend relapse and graft failure: a review of current literatureSaeed Mohammadi0Amir Hossein Norooznezhad1Ashraf Malek Mohammadi2Hajar Nasiri3Mohsen Nikbakht4Najmaldin Saki5Mohammad Vaezi6Kamran Alimoghaddam7Ardeshir Ghavamzadeh8Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical SciencesRegenerative Medicine Research Center, Kermanshah University of Medical SciencesHematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical SciencesHematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical SciencesHematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical SciencesThalassemia and Hemoglobinopathy Research Center, Ahvaz Jundishapur University of Medical SciencesHematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical SciencesHematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical SciencesHematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical SciencesAbstract Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been considered as a valuable approach in treatment of numerous malignant and none malignant hematologic disorders. However, relapse and poor graft function (PGF) after allo-SCT remain to be controversial issues which may affect the transplantation outcome. Relevant articles were searched in MEDLINE database (2000–2016) using keywords and phrases: donor lymphocyte infusions, allogeneic stem cells transplantation, relapsed hematologic malignancies, booster schedules, cell dose, laboratory monitoring protocols and technical aspects of apheresis. Relapse of disease and PGF could be reduced via noting some main points such as choosing the suitable time and patient for donor lymphocyte infusion (DLI) and also determination of patients who ought to candidate for second allogeneic HSCT or for the use of stem cell boost. DLI and stem cell booster are promising treatment strategies noted in this review. Finally, this paper discusses indications and technical aspects of DLI and stem cell booster in hematological malignancies and emphasizes their therapeutic or pre-emptive potentials.http://link.springer.com/article/10.1186/s40164-017-0082-5Peripheral bloodStem cells transplantationRelapseGraft failure |
| spellingShingle | Saeed Mohammadi Amir Hossein Norooznezhad Ashraf Malek Mohammadi Hajar Nasiri Mohsen Nikbakht Najmaldin Saki Mohammad Vaezi Kamran Alimoghaddam Ardeshir Ghavamzadeh Optimizing peripheral blood stem cells transplantation outcome through amend relapse and graft failure: a review of current literature Experimental Hematology & Oncology Peripheral blood Stem cells transplantation Relapse Graft failure |
| title | Optimizing peripheral blood stem cells transplantation outcome through amend relapse and graft failure: a review of current literature |
| title_full | Optimizing peripheral blood stem cells transplantation outcome through amend relapse and graft failure: a review of current literature |
| title_fullStr | Optimizing peripheral blood stem cells transplantation outcome through amend relapse and graft failure: a review of current literature |
| title_full_unstemmed | Optimizing peripheral blood stem cells transplantation outcome through amend relapse and graft failure: a review of current literature |
| title_short | Optimizing peripheral blood stem cells transplantation outcome through amend relapse and graft failure: a review of current literature |
| title_sort | optimizing peripheral blood stem cells transplantation outcome through amend relapse and graft failure a review of current literature |
| topic | Peripheral blood Stem cells transplantation Relapse Graft failure |
| url | http://link.springer.com/article/10.1186/s40164-017-0082-5 |
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