Nomogram for predicting severe abdominal pain after initial conventional transarterial chemoembolisation for hepatocellular carcinoma: a retrospective study
Abstract Transarterial chemoembolisation (TACE) is a standard therapy for hepatocellular carcinoma (HCC). However, adverse events, including abdominal pain, are common. This study aimed to investigate and verify the feasibility of a nomogram model to predict severe abdominal pain after first convent...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-12-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-49509-z |
| _version_ | 1827581616485040128 |
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| author | Huixia Qin Xuhua Xiao Houxiang Ya Jinhai Li Fugang Liang Haiqing Jin Lianghuan Liao Yaohua Li Jiahui Qin Jue Yu Jing Gu Chunmei Zhou Ming Jin Ying Miao Shuqun Li |
| author_facet | Huixia Qin Xuhua Xiao Houxiang Ya Jinhai Li Fugang Liang Haiqing Jin Lianghuan Liao Yaohua Li Jiahui Qin Jue Yu Jing Gu Chunmei Zhou Ming Jin Ying Miao Shuqun Li |
| author_sort | Huixia Qin |
| collection | DOAJ |
| description | Abstract Transarterial chemoembolisation (TACE) is a standard therapy for hepatocellular carcinoma (HCC). However, adverse events, including abdominal pain, are common. This study aimed to investigate and verify the feasibility of a nomogram model to predict severe abdominal pain after first conventional TACE (cTACE) among patients with HCC. Patients with HCC treated with cTACE between October 28, 2019, and August 5, 2022, at a single centre were enrolled (n = 216). Patients were divided into training and validation cohorts (ratio, 7:3). A visual analogue scale score between 7 and 10 was considered severe abdominal pain. A total of 127 (58.8%) patients complained of severe abdominal pain after first cTACE treatment. The nomogram considered age and tumour number and size. The nomogram demonstrated good discrimination, with a C-index of 0.749 (95% confidence interval [CI], 0.617, 0.881). Further, the C-index in the validation cohort reached 0.728 (95% CI 0.592, 0.864). The calibration curves showed ideal agreement between the prediction and real observations, and the nomogram decision curve analysis performed well. The nomogram model can provide an accurate prediction of severe abdominal pain in patients with HCC after first cTACE, aiding in the personalization of pain management and providing novel insights into hospital nursing. |
| first_indexed | 2024-03-08T22:38:57Z |
| format | Article |
| id | doaj.art-ff70ed2c97444a79848eb07bc7458add |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T22:38:57Z |
| publishDate | 2023-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ff70ed2c97444a79848eb07bc7458add2023-12-17T12:18:27ZengNature PortfolioScientific Reports2045-23222023-12-0113111010.1038/s41598-023-49509-zNomogram for predicting severe abdominal pain after initial conventional transarterial chemoembolisation for hepatocellular carcinoma: a retrospective studyHuixia Qin0Xuhua Xiao1Houxiang Ya2Jinhai Li3Fugang Liang4Haiqing Jin5Lianghuan Liao6Yaohua Li7Jiahui Qin8Jue Yu9Jing Gu10Chunmei Zhou11Ming Jin12Ying Miao13Shuqun Li14Department of Interventional Radiology Center, Affiliated Hospital of Guilin Medical UniversityDepartment of Gastroenterology, Affiliated Hospital of Guilin Medical UniversityDepartment of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical UniversityDepartment of Liver and Gall Surgery, The Third Affiliated Hospital of Wenzhou Medical UniversityDepartment of Interventional Radiology Center, Affiliated Hospital of Guilin Medical UniversityDepartment of Interventional Radiology Center, Affiliated Hospital of Guilin Medical UniversityDepartment of Interventional Radiology Center, Affiliated Hospital of Guilin Medical UniversityDepartment of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical UniversityDepartment of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical UniversityDepartment of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical UniversityDepartment of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical UniversityDepartment of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical UniversityDepartment of Vascular Intervention, Affiliated Hospital of Guilin Medical UniversityDepartment of Vascular Intervention, Affiliated Hospital of Guilin Medical UniversityDepartment of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical UniversityAbstract Transarterial chemoembolisation (TACE) is a standard therapy for hepatocellular carcinoma (HCC). However, adverse events, including abdominal pain, are common. This study aimed to investigate and verify the feasibility of a nomogram model to predict severe abdominal pain after first conventional TACE (cTACE) among patients with HCC. Patients with HCC treated with cTACE between October 28, 2019, and August 5, 2022, at a single centre were enrolled (n = 216). Patients were divided into training and validation cohorts (ratio, 7:3). A visual analogue scale score between 7 and 10 was considered severe abdominal pain. A total of 127 (58.8%) patients complained of severe abdominal pain after first cTACE treatment. The nomogram considered age and tumour number and size. The nomogram demonstrated good discrimination, with a C-index of 0.749 (95% confidence interval [CI], 0.617, 0.881). Further, the C-index in the validation cohort reached 0.728 (95% CI 0.592, 0.864). The calibration curves showed ideal agreement between the prediction and real observations, and the nomogram decision curve analysis performed well. The nomogram model can provide an accurate prediction of severe abdominal pain in patients with HCC after first cTACE, aiding in the personalization of pain management and providing novel insights into hospital nursing.https://doi.org/10.1038/s41598-023-49509-z |
| spellingShingle | Huixia Qin Xuhua Xiao Houxiang Ya Jinhai Li Fugang Liang Haiqing Jin Lianghuan Liao Yaohua Li Jiahui Qin Jue Yu Jing Gu Chunmei Zhou Ming Jin Ying Miao Shuqun Li Nomogram for predicting severe abdominal pain after initial conventional transarterial chemoembolisation for hepatocellular carcinoma: a retrospective study Scientific Reports |
| title | Nomogram for predicting severe abdominal pain after initial conventional transarterial chemoembolisation for hepatocellular carcinoma: a retrospective study |
| title_full | Nomogram for predicting severe abdominal pain after initial conventional transarterial chemoembolisation for hepatocellular carcinoma: a retrospective study |
| title_fullStr | Nomogram for predicting severe abdominal pain after initial conventional transarterial chemoembolisation for hepatocellular carcinoma: a retrospective study |
| title_full_unstemmed | Nomogram for predicting severe abdominal pain after initial conventional transarterial chemoembolisation for hepatocellular carcinoma: a retrospective study |
| title_short | Nomogram for predicting severe abdominal pain after initial conventional transarterial chemoembolisation for hepatocellular carcinoma: a retrospective study |
| title_sort | nomogram for predicting severe abdominal pain after initial conventional transarterial chemoembolisation for hepatocellular carcinoma a retrospective study |
| url | https://doi.org/10.1038/s41598-023-49509-z |
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