MicroRNAs in Cancer Treatment-Induced Cardiotoxicity
Cancer treatment has made significant progress in the cure of different types of tumors. Nevertheless, its clinical use is limited by unwanted cardiotoxicity. Aside from the conventional chemotherapy approaches, even the most newly developed, i.e., molecularly targeted therapy and immunotherapy, exh...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-03-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/3/704 |
| _version_ | 1797706024573992960 |
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| author | Laura Pellegrini Sara Sileno Marco D’Agostino Eleonora Foglio Maria Cristina Florio Vincenzo Guzzanti Matteo Antonio Russo Federica Limana Alessandra Magenta |
| author_facet | Laura Pellegrini Sara Sileno Marco D’Agostino Eleonora Foglio Maria Cristina Florio Vincenzo Guzzanti Matteo Antonio Russo Federica Limana Alessandra Magenta |
| author_sort | Laura Pellegrini |
| collection | DOAJ |
| description | Cancer treatment has made significant progress in the cure of different types of tumors. Nevertheless, its clinical use is limited by unwanted cardiotoxicity. Aside from the conventional chemotherapy approaches, even the most newly developed, i.e., molecularly targeted therapy and immunotherapy, exhibit a similar frequency and severity of toxicities that range from subclinical ventricular dysfunction to severe cardiomyopathy and, ultimately, congestive heart failure. Specific mechanisms leading to cardiotoxicity still remain to be elucidated. For instance, oxidative stress and DNA damage are considered key players in mediating cardiotoxicity in different treatments. microRNAs (miRNAs) act as key regulators in cell proliferation, cell death, apoptosis, and cell differentiation. Their dysregulation has been associated with adverse cardiac remodeling and toxicity. This review provides an overview of the cardiotoxicity induced by different oncologic treatments and potential miRNAs involved in this effect that could be used as possible therapeutic targets. |
| first_indexed | 2024-03-12T05:46:06Z |
| format | Article |
| id | doaj.art-ff712318266d419a89af3e4d39f9796b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T05:46:06Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ff712318266d419a89af3e4d39f9796b2023-09-03T05:38:35ZengMDPI AGCancers2072-66942020-03-0112370410.3390/cancers12030704cancers12030704MicroRNAs in Cancer Treatment-Induced CardiotoxicityLaura Pellegrini0Sara Sileno1Marco D’Agostino2Eleonora Foglio3Maria Cristina Florio4Vincenzo Guzzanti5Matteo Antonio Russo6Federica Limana7Alessandra Magenta8Institute of Oncology Research (IOR), 6500 Bellinzona, SwitzerlandIstituto Dermopatico dell’Immacolata, IDI-IRCCS, Experimental Immunology Laboratory, Via dei Monti di Creta 104, 00167 Rome, ItalyIstituto Dermopatico dell’Immacolata, IDI-IRCCS, Experimental Immunology Laboratory, Via dei Monti di Creta 104, 00167 Rome, ItalyDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, ItalyLaboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USAIstituto Dermopatico dell’Immacolata, IDI-IRCCS, 00167 Rome, ItalyIRCCS San Raffaele Pisana and MEBIC Consortium, 00166 Rome, ItalySan Raffaele Open University, 00166 Rome, ItalyIstituto Dermopatico dell’Immacolata, IDI-IRCCS, Experimental Immunology Laboratory, Via dei Monti di Creta 104, 00167 Rome, ItalyCancer treatment has made significant progress in the cure of different types of tumors. Nevertheless, its clinical use is limited by unwanted cardiotoxicity. Aside from the conventional chemotherapy approaches, even the most newly developed, i.e., molecularly targeted therapy and immunotherapy, exhibit a similar frequency and severity of toxicities that range from subclinical ventricular dysfunction to severe cardiomyopathy and, ultimately, congestive heart failure. Specific mechanisms leading to cardiotoxicity still remain to be elucidated. For instance, oxidative stress and DNA damage are considered key players in mediating cardiotoxicity in different treatments. microRNAs (miRNAs) act as key regulators in cell proliferation, cell death, apoptosis, and cell differentiation. Their dysregulation has been associated with adverse cardiac remodeling and toxicity. This review provides an overview of the cardiotoxicity induced by different oncologic treatments and potential miRNAs involved in this effect that could be used as possible therapeutic targets.https://www.mdpi.com/2072-6694/12/3/704micrornascancer therapycardiovascular diseasescardiotoxicity |
| spellingShingle | Laura Pellegrini Sara Sileno Marco D’Agostino Eleonora Foglio Maria Cristina Florio Vincenzo Guzzanti Matteo Antonio Russo Federica Limana Alessandra Magenta MicroRNAs in Cancer Treatment-Induced Cardiotoxicity Cancers micrornas cancer therapy cardiovascular diseases cardiotoxicity |
| title | MicroRNAs in Cancer Treatment-Induced Cardiotoxicity |
| title_full | MicroRNAs in Cancer Treatment-Induced Cardiotoxicity |
| title_fullStr | MicroRNAs in Cancer Treatment-Induced Cardiotoxicity |
| title_full_unstemmed | MicroRNAs in Cancer Treatment-Induced Cardiotoxicity |
| title_short | MicroRNAs in Cancer Treatment-Induced Cardiotoxicity |
| title_sort | micrornas in cancer treatment induced cardiotoxicity |
| topic | micrornas cancer therapy cardiovascular diseases cardiotoxicity |
| url | https://www.mdpi.com/2072-6694/12/3/704 |
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