Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity
A series of lipophilic 2-substituted 5,7-di-tert-butylbenzoxazoles was prepared in average yields by the reaction of 3,5-di-tert-butyl-1,2-benzoquinone with amino acids and dipeptides bearing N-terminal glycine. Dipeptides having other N-terminal amino acids undergo oxidative deamination. 5,7-Di-ter...
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MDPI AG
2005-08-01
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Series: | Molecules |
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Online Access: | http://www.mdpi.com/1420-3049/10/7/783/ |
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author | Jarmila Kaustova Vladimir Buchta Václav Horak Jarmila Vinsova |
author_facet | Jarmila Kaustova Vladimir Buchta Václav Horak Jarmila Vinsova |
author_sort | Jarmila Kaustova |
collection | DOAJ |
description | A series of lipophilic 2-substituted 5,7-di-tert-butylbenzoxazoles was prepared in average yields by the reaction of 3,5-di-tert-butyl-1,2-benzoquinone with amino acids and dipeptides bearing N-terminal glycine. Dipeptides having other N-terminal amino acids undergo oxidative deamination. 5,7-Di-tert-butylbenzoxazoles have shown activity against Mycobacterium tuberculosis and some nontuberculous strains where isoniazid has been inactive. Antifungal activity was mediocre. |
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format | Article |
id | doaj.art-ff712574b97e4f7db63936f66976c71f |
institution | Directory Open Access Journal |
issn | 1420-3049 |
language | English |
last_indexed | 2024-04-13T14:41:09Z |
publishDate | 2005-08-01 |
publisher | MDPI AG |
record_format | Article |
series | Molecules |
spelling | doaj.art-ff712574b97e4f7db63936f66976c71f2022-12-22T02:42:54ZengMDPI AGMolecules1420-30492005-08-0110778379310.3390/10070783Highly Lipophilic Benzoxazoles with Potential Antibacterial ActivityJarmila KaustovaVladimir BuchtaVáclav HorakJarmila VinsovaA series of lipophilic 2-substituted 5,7-di-tert-butylbenzoxazoles was prepared in average yields by the reaction of 3,5-di-tert-butyl-1,2-benzoquinone with amino acids and dipeptides bearing N-terminal glycine. Dipeptides having other N-terminal amino acids undergo oxidative deamination. 5,7-Di-tert-butylbenzoxazoles have shown activity against Mycobacterium tuberculosis and some nontuberculous strains where isoniazid has been inactive. Antifungal activity was mediocre.http://www.mdpi.com/1420-3049/10/7/783/35-di-tert-Butyl-12-benzoquinone57-di-tert-butylbenzoxazolesantimyco- bacterial activityantifungal activity |
spellingShingle | Jarmila Kaustova Vladimir Buchta Václav Horak Jarmila Vinsova Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity Molecules 3 5-di-tert-Butyl-1 2-benzoquinone 5 7-di-tert-butylbenzoxazoles antimyco- bacterial activity antifungal activity |
title | Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity |
title_full | Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity |
title_fullStr | Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity |
title_full_unstemmed | Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity |
title_short | Highly Lipophilic Benzoxazoles with Potential Antibacterial Activity |
title_sort | highly lipophilic benzoxazoles with potential antibacterial activity |
topic | 3 5-di-tert-Butyl-1 2-benzoquinone 5 7-di-tert-butylbenzoxazoles antimyco- bacterial activity antifungal activity |
url | http://www.mdpi.com/1420-3049/10/7/783/ |
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