Development of the quadrivalent live attenuated influenza vaccine including two influenza B lineages – Victoria and Yamagata
This work is devoted to the research of the live attenuated influenza vaccine (LAIV) comprising two reassortant B/USSR/60/69-based vaccine influenza viruses Victoria and Yamagata. the intranasal immunization of the CBA mice with both victoria and yamagata strains induced 100% lung protection against...
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| Format: | Article |
| Language: | English |
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Central Research Institute for Epidemiology
2016-02-01
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| Series: | Вопросы вирусологии |
| Subjects: | |
| Online Access: | https://virusjour.crie.ru/jour/article/viewFile/298/176 |
| _version_ | 1797782247821017088 |
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| author | Yu. A. Desheva T. A. Smolonogina E. M. Doroshenko L. G. Rudenko |
| author_facet | Yu. A. Desheva T. A. Smolonogina E. M. Doroshenko L. G. Rudenko |
| author_sort | Yu. A. Desheva |
| collection | DOAJ |
| description | This work is devoted to the research of the live attenuated influenza vaccine (LAIV) comprising two reassortant B/USSR/60/69-based vaccine influenza viruses Victoria and Yamagata. the intranasal immunization of the CBA mice with both victoria and yamagata strains induced 100% lung protection against the subsequent infection with the wild-type influenza B viruses of any antigen lineage. the quadrivalent LAIV (qLAIV) comprising both reassortant influenza B viruses Victoria and Yamagata were safe and areactogenic in adult volunteers. Following qLAIV administration the immune response was achieved to both Victoria and Yamagata lineages. |
| first_indexed | 2024-03-13T00:08:18Z |
| format | Article |
| id | doaj.art-ff7356ede2184a089df804905230a5a3 |
| institution | Directory Open Access Journal |
| issn | 0507-4088 2411-2097 |
| language | English |
| last_indexed | 2024-03-13T00:08:18Z |
| publishDate | 2016-02-01 |
| publisher | Central Research Institute for Epidemiology |
| record_format | Article |
| series | Вопросы вирусологии |
| spelling | doaj.art-ff7356ede2184a089df804905230a5a32023-07-12T20:03:15ZengCentral Research Institute for EpidemiologyВопросы вирусологии0507-40882411-20972016-02-01611162010.18821/0507-4088-2016-61-1-16-20252Development of the quadrivalent live attenuated influenza vaccine including two influenza B lineages – Victoria and YamagataYu. A. Desheva0T. A. Smolonogina1E. M. Doroshenko2L. G. Rudenko3Institute of Experimental MedicineInstitute of Experimental MedicineInstitute of Experimental MedicineInstitute of Experimental MedicineThis work is devoted to the research of the live attenuated influenza vaccine (LAIV) comprising two reassortant B/USSR/60/69-based vaccine influenza viruses Victoria and Yamagata. the intranasal immunization of the CBA mice with both victoria and yamagata strains induced 100% lung protection against the subsequent infection with the wild-type influenza B viruses of any antigen lineage. the quadrivalent LAIV (qLAIV) comprising both reassortant influenza B viruses Victoria and Yamagata were safe and areactogenic in adult volunteers. Following qLAIV administration the immune response was achieved to both Victoria and Yamagata lineages.https://virusjour.crie.ru/jour/article/viewFile/298/176live influenza vaccineinfluenza bimmunogenicity |
| spellingShingle | Yu. A. Desheva T. A. Smolonogina E. M. Doroshenko L. G. Rudenko Development of the quadrivalent live attenuated influenza vaccine including two influenza B lineages – Victoria and Yamagata Вопросы вирусологии live influenza vaccine influenza b immunogenicity |
| title | Development of the quadrivalent live attenuated influenza vaccine including two influenza B lineages – Victoria and Yamagata |
| title_full | Development of the quadrivalent live attenuated influenza vaccine including two influenza B lineages – Victoria and Yamagata |
| title_fullStr | Development of the quadrivalent live attenuated influenza vaccine including two influenza B lineages – Victoria and Yamagata |
| title_full_unstemmed | Development of the quadrivalent live attenuated influenza vaccine including two influenza B lineages – Victoria and Yamagata |
| title_short | Development of the quadrivalent live attenuated influenza vaccine including two influenza B lineages – Victoria and Yamagata |
| title_sort | development of the quadrivalent live attenuated influenza vaccine including two influenza b lineages victoria and yamagata |
| topic | live influenza vaccine influenza b immunogenicity |
| url | https://virusjour.crie.ru/jour/article/viewFile/298/176 |
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