Association Between Physical Performance and Cognitive Function in Chinese Community-Dwelling Older Adults: Serial Mediation of Malnutrition and Depression
Xinze Wu,1,2,* Guozhen Hou,1,2,* Peipei Han,1 Xing Yu,1 Xiaoyu Chen,1 Peiyu Song,3 Yuanyuan Zhang,1 Yinjiao Zhao,3 Fandi Xie,3 Shumeng Niu,3 Hao Hu,3 Chengyi Sun,1 Yuechen Zhao,1 Hongbing Wang,4 Qi Guo1 1Department of Rehabilitation Medicine, Shanghai University of Medicine and Healt...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-07-01
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| Series: | Clinical Interventions in Aging |
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| Online Access: | https://www.dovepress.com/association-between-physical-performance-and-cognitive-function-in-chi-peer-reviewed-fulltext-article-CIA |
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| author | Wu X Hou G Han P Yu X Chen X Song P Zhang Y Zhao Y Xie F Niu S Hu H Sun C Zhao Y Wang H Guo Q |
| author_facet | Wu X Hou G Han P Yu X Chen X Song P Zhang Y Zhao Y Xie F Niu S Hu H Sun C Zhao Y Wang H Guo Q |
| author_sort | Wu X |
| collection | DOAJ |
| description | Xinze Wu,1,2,* Guozhen Hou,1,2,* Peipei Han,1 Xing Yu,1 Xiaoyu Chen,1 Peiyu Song,3 Yuanyuan Zhang,1 Yinjiao Zhao,3 Fandi Xie,3 Shumeng Niu,3 Hao Hu,3 Chengyi Sun,1 Yuechen Zhao,1 Hongbing Wang,4 Qi Guo1 1Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences, Shanghai, People’s Republic of China; 2College of Exercise and Health Science, Tianjin University of Sport, Tianjin, People’s Republic of China; 3Shanghai Jiangwan Hospital, Shanghai, People’s Republic of China; 4Department of Rehabilitation, Shanghai Fourth Rehabilitation Hospital, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongbing WangDepartment of Rehabilitation, Shanghai Fourth Rehabilitation Hospital, Shanghai, 20040, People’s Republic of ChinaEmail 15301799929@163.comQi GuoCollege of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences, 279 Zhouzhu Highway, Pudong New Area, Shanghai, 201318, People’s Republic of ChinaTel/Fax +86-22-8333-6977Email guoqijp@gmail.comPurpose: We aimed to propose a serial mediational model to further analyze the relationship between poor physical performance, malnutrition, depression and cognitive impairment in Chinese community-dwelling older adults.Patients and Methods: This study consisted of 1386 community-dwelling Chinese older adults aged 65 years and older in Shanghai, China. Mild cognitive impairment (MCI) was assessed by the Mini-Mental State Examination (MMSE) and Instrumental Activities Of Daily Living (IADL). Physical performance was assessed by short physical performance battery (SPPB). Malnutrition was defined with the Mini Nutritional Assessment (MNA). Depressive symptoms were evaluated by the 30-item Geriatric Depression Scale (GDS). Serial multiple mediator models were used.Results: The mean age of the final analysis sample was 73.62± 6.14, and 57.6% (n=809) were females. The prevalence of MCI was 14.35% (n=199). Physical performance (p< 0.001), nutritional status (p=0.025), and depressive symptoms (p=0.002) were correlated with MCI. The serial mediational model revealed that MNA and GDS scores significantly mediated association of SPPB and MMSE scores (c’=0.4728, p< 0.001). Furthermore, depressive symptoms significantly mediated the association of physical performance and cognition (p=0.0311), while malnutrition had no independent mediating effect between these two factors (p=0.794).Conclusion: Our study examined the serial multiple mediation roles of nutritional status and depressive symptoms on the relationship between physical performance and cognitive function in community-dwelling Chinese older adults. Older adults who were in poor physical condition tend to have worse nutritional status, more severe depression, and poorer cognitive function.Keywords: mild cognitive impairment, nutritional status, depressive symptoms, physical function |
| first_indexed | 2024-12-20T21:04:27Z |
| format | Article |
| id | doaj.art-ff750e24a4e8440eb5074425871057ff |
| institution | Directory Open Access Journal |
| issn | 1178-1998 |
| language | English |
| last_indexed | 2024-12-20T21:04:27Z |
| publishDate | 2021-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Interventions in Aging |
| spelling | doaj.art-ff750e24a4e8440eb5074425871057ff2022-12-21T19:26:39ZengDove Medical PressClinical Interventions in Aging1178-19982021-07-01Volume 161327133566822Association Between Physical Performance and Cognitive Function in Chinese Community-Dwelling Older Adults: Serial Mediation of Malnutrition and DepressionWu XHou GHan PYu XChen XSong PZhang YZhao YXie FNiu SHu HSun CZhao YWang HGuo QXinze Wu,1,2,* Guozhen Hou,1,2,* Peipei Han,1 Xing Yu,1 Xiaoyu Chen,1 Peiyu Song,3 Yuanyuan Zhang,1 Yinjiao Zhao,3 Fandi Xie,3 Shumeng Niu,3 Hao Hu,3 Chengyi Sun,1 Yuechen Zhao,1 Hongbing Wang,4 Qi Guo1 1Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences, Shanghai, People’s Republic of China; 2College of Exercise and Health Science, Tianjin University of Sport, Tianjin, People’s Republic of China; 3Shanghai Jiangwan Hospital, Shanghai, People’s Republic of China; 4Department of Rehabilitation, Shanghai Fourth Rehabilitation Hospital, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongbing WangDepartment of Rehabilitation, Shanghai Fourth Rehabilitation Hospital, Shanghai, 20040, People’s Republic of ChinaEmail 15301799929@163.comQi GuoCollege of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences, 279 Zhouzhu Highway, Pudong New Area, Shanghai, 201318, People’s Republic of ChinaTel/Fax +86-22-8333-6977Email guoqijp@gmail.comPurpose: We aimed to propose a serial mediational model to further analyze the relationship between poor physical performance, malnutrition, depression and cognitive impairment in Chinese community-dwelling older adults.Patients and Methods: This study consisted of 1386 community-dwelling Chinese older adults aged 65 years and older in Shanghai, China. Mild cognitive impairment (MCI) was assessed by the Mini-Mental State Examination (MMSE) and Instrumental Activities Of Daily Living (IADL). Physical performance was assessed by short physical performance battery (SPPB). Malnutrition was defined with the Mini Nutritional Assessment (MNA). Depressive symptoms were evaluated by the 30-item Geriatric Depression Scale (GDS). Serial multiple mediator models were used.Results: The mean age of the final analysis sample was 73.62± 6.14, and 57.6% (n=809) were females. The prevalence of MCI was 14.35% (n=199). Physical performance (p< 0.001), nutritional status (p=0.025), and depressive symptoms (p=0.002) were correlated with MCI. The serial mediational model revealed that MNA and GDS scores significantly mediated association of SPPB and MMSE scores (c’=0.4728, p< 0.001). Furthermore, depressive symptoms significantly mediated the association of physical performance and cognition (p=0.0311), while malnutrition had no independent mediating effect between these two factors (p=0.794).Conclusion: Our study examined the serial multiple mediation roles of nutritional status and depressive symptoms on the relationship between physical performance and cognitive function in community-dwelling Chinese older adults. Older adults who were in poor physical condition tend to have worse nutritional status, more severe depression, and poorer cognitive function.Keywords: mild cognitive impairment, nutritional status, depressive symptoms, physical functionhttps://www.dovepress.com/association-between-physical-performance-and-cognitive-function-in-chi-peer-reviewed-fulltext-article-CIAmild cognitive impairmentnutritional statusdepressive symptomsphysical function |
| spellingShingle | Wu X Hou G Han P Yu X Chen X Song P Zhang Y Zhao Y Xie F Niu S Hu H Sun C Zhao Y Wang H Guo Q Association Between Physical Performance and Cognitive Function in Chinese Community-Dwelling Older Adults: Serial Mediation of Malnutrition and Depression Clinical Interventions in Aging mild cognitive impairment nutritional status depressive symptoms physical function |
| title | Association Between Physical Performance and Cognitive Function in Chinese Community-Dwelling Older Adults: Serial Mediation of Malnutrition and Depression |
| title_full | Association Between Physical Performance and Cognitive Function in Chinese Community-Dwelling Older Adults: Serial Mediation of Malnutrition and Depression |
| title_fullStr | Association Between Physical Performance and Cognitive Function in Chinese Community-Dwelling Older Adults: Serial Mediation of Malnutrition and Depression |
| title_full_unstemmed | Association Between Physical Performance and Cognitive Function in Chinese Community-Dwelling Older Adults: Serial Mediation of Malnutrition and Depression |
| title_short | Association Between Physical Performance and Cognitive Function in Chinese Community-Dwelling Older Adults: Serial Mediation of Malnutrition and Depression |
| title_sort | association between physical performance and cognitive function in chinese community dwelling older adults serial mediation of malnutrition and depression |
| topic | mild cognitive impairment nutritional status depressive symptoms physical function |
| url | https://www.dovepress.com/association-between-physical-performance-and-cognitive-function-in-chi-peer-reviewed-fulltext-article-CIA |
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