Single exponential decay waveform; a synergistic combination of electroporation and electrolysis (E2) for tissue ablation
Background Electrolytic ablation and electroporation based ablation are minimally invasive, non-thermal surgical technologies that employ electrical currents and electric fields to ablate undesirable cells in a volume of tissue. In this study, we explore the attributes of a new tissue ablation techn...
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| Format: | Article |
| Language: | English |
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PeerJ Inc.
2017-04-01
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| Series: | PeerJ |
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| Online Access: | https://peerj.com/articles/3190.pdf |
| _version_ | 1827607388856778752 |
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| author | Nina Klein Enric Guenther Paul Mikus Michael K. Stehling Boris Rubinsky |
| author_facet | Nina Klein Enric Guenther Paul Mikus Michael K. Stehling Boris Rubinsky |
| author_sort | Nina Klein |
| collection | DOAJ |
| description | Background Electrolytic ablation and electroporation based ablation are minimally invasive, non-thermal surgical technologies that employ electrical currents and electric fields to ablate undesirable cells in a volume of tissue. In this study, we explore the attributes of a new tissue ablation technology that simultaneously delivers a synergistic combination of electroporation and electrolysis (E2). Method A new device that delivers a controlled dose of electroporation field and electrolysis currents in the form of a single exponential decay waveform (EDW) was applied to the pig liver, and the effect of various parameters on the extent of tissue ablation was examined with histology. Results Histological analysis shows that E2 delivered as EDW can produce tissue ablation in volumes of clinical significance, using electrical and temporal parameters which, if used in electroporation or electrolysis separately, cannot ablate the tissue. Discussion The E2 combination has advantages over the three basic technologies of non-thermal ablation: electrolytic ablation, electrochemical ablation (reversible electroporation with injection of drugs) and irreversible electroporation. E2 ablates clinically relevant volumes of tissue in a shorter period of time than electrolysis and electroporation, without the need to inject drugs as in reversible electroporation or use paralyzing anesthesia as in irreversible electroporation. |
| first_indexed | 2024-03-09T06:53:44Z |
| format | Article |
| id | doaj.art-ff753a1a79b14575aa1c2bd739c6c2f7 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:53:44Z |
| publishDate | 2017-04-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
| series | PeerJ |
| spelling | doaj.art-ff753a1a79b14575aa1c2bd739c6c2f72023-12-03T10:16:03ZengPeerJ Inc.PeerJ2167-83592017-04-015e319010.7717/peerj.3190Single exponential decay waveform; a synergistic combination of electroporation and electrolysis (E2) for tissue ablationNina Klein0Enric Guenther1Paul Mikus2Michael K. Stehling3Boris Rubinsky4Inter Science GmbH, Gisikon, SwitzerlandInter Science GmbH, Gisikon, SwitzerlandInter Science GmbH, Gisikon, SwitzerlandInter Science GmbH, Gisikon, SwitzerlandInter Science GmbH, Gisikon, SwitzerlandBackground Electrolytic ablation and electroporation based ablation are minimally invasive, non-thermal surgical technologies that employ electrical currents and electric fields to ablate undesirable cells in a volume of tissue. In this study, we explore the attributes of a new tissue ablation technology that simultaneously delivers a synergistic combination of electroporation and electrolysis (E2). Method A new device that delivers a controlled dose of electroporation field and electrolysis currents in the form of a single exponential decay waveform (EDW) was applied to the pig liver, and the effect of various parameters on the extent of tissue ablation was examined with histology. Results Histological analysis shows that E2 delivered as EDW can produce tissue ablation in volumes of clinical significance, using electrical and temporal parameters which, if used in electroporation or electrolysis separately, cannot ablate the tissue. Discussion The E2 combination has advantages over the three basic technologies of non-thermal ablation: electrolytic ablation, electrochemical ablation (reversible electroporation with injection of drugs) and irreversible electroporation. E2 ablates clinically relevant volumes of tissue in a shorter period of time than electrolysis and electroporation, without the need to inject drugs as in reversible electroporation or use paralyzing anesthesia as in irreversible electroporation.https://peerj.com/articles/3190.pdfTissue ablationSynergy electroporation and electrolysisLiverElectrolytic ablationReversible electroporationIrreversible electroporation |
| spellingShingle | Nina Klein Enric Guenther Paul Mikus Michael K. Stehling Boris Rubinsky Single exponential decay waveform; a synergistic combination of electroporation and electrolysis (E2) for tissue ablation PeerJ Tissue ablation Synergy electroporation and electrolysis Liver Electrolytic ablation Reversible electroporation Irreversible electroporation |
| title | Single exponential decay waveform; a synergistic combination of electroporation and electrolysis (E2) for tissue ablation |
| title_full | Single exponential decay waveform; a synergistic combination of electroporation and electrolysis (E2) for tissue ablation |
| title_fullStr | Single exponential decay waveform; a synergistic combination of electroporation and electrolysis (E2) for tissue ablation |
| title_full_unstemmed | Single exponential decay waveform; a synergistic combination of electroporation and electrolysis (E2) for tissue ablation |
| title_short | Single exponential decay waveform; a synergistic combination of electroporation and electrolysis (E2) for tissue ablation |
| title_sort | single exponential decay waveform a synergistic combination of electroporation and electrolysis e2 for tissue ablation |
| topic | Tissue ablation Synergy electroporation and electrolysis Liver Electrolytic ablation Reversible electroporation Irreversible electroporation |
| url | https://peerj.com/articles/3190.pdf |
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