Co-Targeting Nucleus Accumbens Associate 1 and NF-κB Signaling Synergistically Inhibits Melanoma Growth
Nucleus-accumbens-associated protein-1 (NAC1) is a cancer-related transcriptional factor encoded by the <i>NACC1</i> gene, which is amplified and overexpressed in various human cancers and has been appreciated as one of the top potential cancer driver genes. NAC1 has therefore been explo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/8/2221 |
| _version_ | 1797585429643395072 |
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| author | Lixiang Gu Xingcong Ren Chrispus Ngule Xiaofang Xiong Jianxun Song Zhiguo Li Jin-Ming Yang |
| author_facet | Lixiang Gu Xingcong Ren Chrispus Ngule Xiaofang Xiong Jianxun Song Zhiguo Li Jin-Ming Yang |
| author_sort | Lixiang Gu |
| collection | DOAJ |
| description | Nucleus-accumbens-associated protein-1 (NAC1) is a cancer-related transcriptional factor encoded by the <i>NACC1</i> gene, which is amplified and overexpressed in various human cancers and has been appreciated as one of the top potential cancer driver genes. NAC1 has therefore been explored as a potential therapeutic target for managing malignant tumors. Here, we show that NAC1 is a negative regulator of NF-κB signaling, and NAC1 depletion enhances the level of the nuclear NF-κB in human melanoma. Furthermore, the inhibition of NF-κB signaling significantly potentiates the antineoplastic activity of the NAC1 inhibition in both the cultured melanoma cells and xenograft tumors. This study identifies a novel NAC1-NF-κB signaling axis in melanoma, offering a promising new therapeutic option to treat melanoma. |
| first_indexed | 2024-03-11T00:07:05Z |
| format | Article |
| id | doaj.art-ff766ba15e3b492c8a13062889e987dc |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T00:07:05Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-ff766ba15e3b492c8a13062889e987dc2023-11-19T00:21:07ZengMDPI AGBiomedicines2227-90592023-08-01118222110.3390/biomedicines11082221Co-Targeting Nucleus Accumbens Associate 1 and NF-κB Signaling Synergistically Inhibits Melanoma GrowthLixiang Gu0Xingcong Ren1Chrispus Ngule2Xiaofang Xiong3Jianxun Song4Zhiguo Li5Jin-Ming Yang6Department of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY 40536, USADepartment of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY 40536, USADepartment of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY 40536, USADepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX 77807, USADepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX 77807, USADepartment of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY 40536, USADepartment of Toxicology and Cancer Biology, College of Medicine, University of Kentucky, Lexington, KY 40536, USANucleus-accumbens-associated protein-1 (NAC1) is a cancer-related transcriptional factor encoded by the <i>NACC1</i> gene, which is amplified and overexpressed in various human cancers and has been appreciated as one of the top potential cancer driver genes. NAC1 has therefore been explored as a potential therapeutic target for managing malignant tumors. Here, we show that NAC1 is a negative regulator of NF-κB signaling, and NAC1 depletion enhances the level of the nuclear NF-κB in human melanoma. Furthermore, the inhibition of NF-κB signaling significantly potentiates the antineoplastic activity of the NAC1 inhibition in both the cultured melanoma cells and xenograft tumors. This study identifies a novel NAC1-NF-κB signaling axis in melanoma, offering a promising new therapeutic option to treat melanoma.https://www.mdpi.com/2227-9059/11/8/2221NAC1melanoma |
| spellingShingle | Lixiang Gu Xingcong Ren Chrispus Ngule Xiaofang Xiong Jianxun Song Zhiguo Li Jin-Ming Yang Co-Targeting Nucleus Accumbens Associate 1 and NF-κB Signaling Synergistically Inhibits Melanoma Growth Biomedicines NAC1 melanoma |
| title | Co-Targeting Nucleus Accumbens Associate 1 and NF-κB Signaling Synergistically Inhibits Melanoma Growth |
| title_full | Co-Targeting Nucleus Accumbens Associate 1 and NF-κB Signaling Synergistically Inhibits Melanoma Growth |
| title_fullStr | Co-Targeting Nucleus Accumbens Associate 1 and NF-κB Signaling Synergistically Inhibits Melanoma Growth |
| title_full_unstemmed | Co-Targeting Nucleus Accumbens Associate 1 and NF-κB Signaling Synergistically Inhibits Melanoma Growth |
| title_short | Co-Targeting Nucleus Accumbens Associate 1 and NF-κB Signaling Synergistically Inhibits Melanoma Growth |
| title_sort | co targeting nucleus accumbens associate 1 and nf κb signaling synergistically inhibits melanoma growth |
| topic | NAC1 melanoma |
| url | https://www.mdpi.com/2227-9059/11/8/2221 |
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