Preparation, In Vitro and In Vivo Evaluation of Nanoemulsion In Situ Gel for Transnasal Delivery of Traditional Chinese Medicine Volatile Oil from <i>Ligusticum sinense</i> Oliv.cv. Chaxiong

Preparation, In Vitro and In Vivo Evaluation of Nanoemulsion In Situ Gel for Transnasal Delivery of Traditional Chinese Medicine Volatile Oil from <i>Ligusticum sinense</i> Oliv.cv. Chaxiong

Ischemic stroke is a difficult-to-treat brain disease that may be attributed to a limited therapeutic time window and lack of effective clinical drugs. Nasal–brain administration is characterized by low systemic toxicity and is a direct and non-invasive brain targeting route. Preliminary studies hav...

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Bibliographic Details
Main Authors: Chunhui Huang, Canjian Wang, Wenliu Zhang, Tao Yang, Mingyan Xia, Xiaomeng Lei, Ying Peng, Yuhuan Wu, Jianfang Feng, Dongxun Li, Guosong Zhang
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Molecules
Subjects:
volatile of <i>Ligusticum sinense</i> Oliv.cv. Chaxiong
nanoemulsion
in situ gel
nasal administration
Online Access:https://www.mdpi.com/1420-3049/27/21/7644

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