Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Expansion of polyglutamine repeats is the cause of at least nine inherited human neurodegenerative disorders, including Huntington's disease (HD). It is widely accepted that deregulation of the transcriptional coactivator CBP by expanded huntingtin (htt) plays an important role in HD molecular...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	S.Y. Cong, B.A. Pepers, T.T. Zhou, H. Kerkdijk, R.A. Roos, G.J. van Ommen, J.C. Dorsman
Μορφή:	Άρθρο
Γλώσσα:	English
Έκδοση:	Elsevier 2012-06-01
Σειρά:	Neurobiology of Disease
Θέματα:	Huntingtin Polyglutamine Jab1 p27(Kip1) Transcriptional deregulation
Διαθέσιμο Online:	http://www.sciencedirect.com/science/article/pii/S0969996112000794

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