Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Expansion of polyglutamine repeats is the cause of at least nine inherited human neurodegenerative disorders, including Huntington's disease (HD). It is widely accepted that deregulation of the transcriptional coactivator CBP by expanded huntingtin (htt) plays an important role in HD molecular...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	S.Y. Cong, B.A. Pepers, T.T. Zhou, H. Kerkdijk, R.A. Roos, G.J. van Ommen, J.C. Dorsman
Формат:	Өгүүллэг
Хэл сонгох:	English
Хэвлэсэн:	Elsevier 2012-06-01
Цуврал:	Neurobiology of Disease
Нөхцлүүд:	Huntingtin Polyglutamine Jab1 p27(Kip1) Transcriptional deregulation
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S0969996112000794

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