Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Expansion of polyglutamine repeats is the cause of at least nine inherited human neurodegenerative disorders, including Huntington's disease (HD). It is widely accepted that deregulation of the transcriptional coactivator CBP by expanded huntingtin (htt) plays an important role in HD molecular...

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Chi tiết về thư mục
Những tác giả chính:	S.Y. Cong, B.A. Pepers, T.T. Zhou, H. Kerkdijk, R.A. Roos, G.J. van Ommen, J.C. Dorsman
Định dạng:	Bài viết
Ngôn ngữ:	English
Được phát hành:	Elsevier 2012-06-01
Loạt:	Neurobiology of Disease
Những chủ đề:	Huntingtin Polyglutamine Jab1 p27(Kip1) Transcriptional deregulation
Truy cập trực tuyến:	http://www.sciencedirect.com/science/article/pii/S0969996112000794

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