Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Expansion of polyglutamine repeats is the cause of at least nine inherited human neurodegenerative disorders, including Huntington's disease (HD). It is widely accepted that deregulation of the transcriptional coactivator CBP by expanded huntingtin (htt) plays an important role in HD molecular...

書目詳細資料
Main Authors:	S.Y. Cong, B.A. Pepers, T.T. Zhou, H. Kerkdijk, R.A. Roos, G.J. van Ommen, J.C. Dorsman
格式:	Article
語言:	English
出版:	Elsevier 2012-06-01
叢編:	Neurobiology of Disease
主題:	Huntingtin Polyglutamine Jab1 p27(Kip1) Transcriptional deregulation
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S0969996112000794

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