Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway

Expansion of polyglutamine repeats is the cause of at least nine inherited human neurodegenerative disorders, including Huntington's disease (HD). It is widely accepted that deregulation of the transcriptional coactivator CBP by expanded huntingtin (htt) plays an important role in HD molecular...

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Detaylı Bibliyografya
Asıl Yazarlar: S.Y. Cong, B.A. Pepers, T.T. Zhou, H. Kerkdijk, R.A. Roos, G.J. van Ommen, J.C. Dorsman
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Elsevier 2012-06-01
Seri Bilgileri:Neurobiology of Disease
Konular:
Huntingtin
Polyglutamine
Jab1
p27(Kip1)
Transcriptional deregulation
Online Erişim:http://www.sciencedirect.com/science/article/pii/S0969996112000794

Internet

http://www.sciencedirect.com/science/article/pii/S0969996112000794

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