Huntingtin with an expanded polyglutamine repeat affects the Jab1-p27(Kip1) pathway
Expansion of polyglutamine repeats is the cause of at least nine inherited human neurodegenerative disorders, including Huntington's disease (HD). It is widely accepted that deregulation of the transcriptional coactivator CBP by expanded huntingtin (htt) plays an important role in HD molecular...
| Main Authors: | , , , , , , |
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| 格式: | Article |
| 語言: | English |
| 出版: |
Elsevier
2012-06-01
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| 叢編: | Neurobiology of Disease |
| 主題: | |
| 在線閱讀: | http://www.sciencedirect.com/science/article/pii/S0969996112000794 |