CD8+ T cell self-tolerance permits responsiveness but limits tissue damage

CD8+ T cell self-tolerance permits responsiveness but limits tissue damage

Self-specific CD8+T cells can escape clonal deletion, but the properties and capabilities of such cells in a physiological setting are unclear. We characterized polyclonal CD8+ T cells specific for the melanocyte antigen tyrosinase-related protein 2 (Trp2) in mice expressing or lacking this enzyme (...

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Bibliographic Details
Main Authors: Emily N Truckenbrod, Kristina S Burrack, Todd P Knutson, Henrique Borges da Silva, Katharine E Block, Stephen D O'Flanagan, Katie R Stagliano, Arthur A Hurwitz, Ross B Fulton, Kristin R Renkema, Stephen C Jameson
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-04-01
Series:eLife
Subjects:
tolerance
T cell
autoimmune response/disease
Online Access:https://elifesciences.org/articles/65615

Internet

https://elifesciences.org/articles/65615

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