Evaluation of the 10 Warning Signs in Primary and Secondary Immunodeficient Patients
ObjectivesTen warning signs of primary immunodeficiency (PID) were suggested by the Jeffrey Modell Foundation (JMF), to increase physician awareness of PID. These warning signs have not yet been evaluated for patients with secondary immunodeficiency (SID). This study investigated whether the 10 warn...
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.900055/full |
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| author | Fadime Ceyda Eldeniz Yahya Gul Alaaddin Yorulmaz Sukru Nail Guner Sevgi Keles Ismail Reisli |
| author_facet | Fadime Ceyda Eldeniz Yahya Gul Alaaddin Yorulmaz Sukru Nail Guner Sevgi Keles Ismail Reisli |
| author_sort | Fadime Ceyda Eldeniz |
| collection | DOAJ |
| description | ObjectivesTen warning signs of primary immunodeficiency (PID) were suggested by the Jeffrey Modell Foundation (JMF), to increase physician awareness of PID. These warning signs have not yet been evaluated for patients with secondary immunodeficiency (SID). This study investigated whether the 10 warning signs used for the diagnosis of PID were also sufficient for the diagnosis of SID, and explored the possibility of additional signs.MethodsThis prospective study was conducted between June and December 2020. The mothers of 162 patients with PID and SID, and mothers of 200 healthy children, were asked to complete a questionnaire about family and personal history in addition to the warning signs of PID developed by the JMF. A JMF score was created by giving one point for each “Yes” answer for the 10 warning signs of PID. Medical records of the patients were evaluated for possible additional warning signs for PID and SID.ResultsThe JMF scores of the PID (3.36 ± 1.65) and SID (3.72 ± 1.12) groups were significantly higher than the scores of the control group (0.34 ± 0.61) (p < 0.05). A sign for immunological evaluation in two patients without warning signs in the PID group was found to be chronic diarrhea. In addition to the 10 JMF warning signs, we found that consanguinity and a family history of tuberculosis were statistically significant in our PID group, compared with the SID and control groups.ConclusionsThe JMF warning signs are important for early diagnosis of PID. Our study showed that these signs may also be used for the early diagnosis of SID in patients and, according to our results, in addition to the 10 JMF signs for PID, parental consanguinity, chronic diarrhea, and a family history of tuberculosis may also be considered warning signs for the early diagnosis of PID. |
| first_indexed | 2024-04-14T00:29:48Z |
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| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-14T00:29:48Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-ff7df8c95a964d6e8e995c4224ce5cad2022-12-22T02:22:36ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-05-011310.3389/fimmu.2022.900055900055Evaluation of the 10 Warning Signs in Primary and Secondary Immunodeficient PatientsFadime Ceyda Eldeniz0Yahya Gul1Alaaddin Yorulmaz2Sukru Nail Guner3Sevgi Keles4Ismail Reisli5Department of Pediatrics, Necmettin Erbakan University, Konya, TurkeyDepartment of Pediatric Allergy and Immunology, Necmettin Erbakan University, Konya, TurkeyDepartment of Pediatrics, Selcuk University, Konya, TurkeyDepartment of Pediatric Allergy and Immunology, Necmettin Erbakan University, Konya, TurkeyDepartment of Pediatric Allergy and Immunology, Necmettin Erbakan University, Konya, TurkeyDepartment of Pediatric Allergy and Immunology, Necmettin Erbakan University, Konya, TurkeyObjectivesTen warning signs of primary immunodeficiency (PID) were suggested by the Jeffrey Modell Foundation (JMF), to increase physician awareness of PID. These warning signs have not yet been evaluated for patients with secondary immunodeficiency (SID). This study investigated whether the 10 warning signs used for the diagnosis of PID were also sufficient for the diagnosis of SID, and explored the possibility of additional signs.MethodsThis prospective study was conducted between June and December 2020. The mothers of 162 patients with PID and SID, and mothers of 200 healthy children, were asked to complete a questionnaire about family and personal history in addition to the warning signs of PID developed by the JMF. A JMF score was created by giving one point for each “Yes” answer for the 10 warning signs of PID. Medical records of the patients were evaluated for possible additional warning signs for PID and SID.ResultsThe JMF scores of the PID (3.36 ± 1.65) and SID (3.72 ± 1.12) groups were significantly higher than the scores of the control group (0.34 ± 0.61) (p < 0.05). A sign for immunological evaluation in two patients without warning signs in the PID group was found to be chronic diarrhea. In addition to the 10 JMF warning signs, we found that consanguinity and a family history of tuberculosis were statistically significant in our PID group, compared with the SID and control groups.ConclusionsThe JMF warning signs are important for early diagnosis of PID. Our study showed that these signs may also be used for the early diagnosis of SID in patients and, according to our results, in addition to the 10 JMF signs for PID, parental consanguinity, chronic diarrhea, and a family history of tuberculosis may also be considered warning signs for the early diagnosis of PID.https://www.frontiersin.org/articles/10.3389/fimmu.2022.900055/fullprimary immunodeficiencysecondary immunodeficiencycombined immunodeficiency10 warning signschildhood |
| spellingShingle | Fadime Ceyda Eldeniz Yahya Gul Alaaddin Yorulmaz Sukru Nail Guner Sevgi Keles Ismail Reisli Evaluation of the 10 Warning Signs in Primary and Secondary Immunodeficient Patients Frontiers in Immunology primary immunodeficiency secondary immunodeficiency combined immunodeficiency 10 warning signs childhood |
| title | Evaluation of the 10 Warning Signs in Primary and Secondary Immunodeficient Patients |
| title_full | Evaluation of the 10 Warning Signs in Primary and Secondary Immunodeficient Patients |
| title_fullStr | Evaluation of the 10 Warning Signs in Primary and Secondary Immunodeficient Patients |
| title_full_unstemmed | Evaluation of the 10 Warning Signs in Primary and Secondary Immunodeficient Patients |
| title_short | Evaluation of the 10 Warning Signs in Primary and Secondary Immunodeficient Patients |
| title_sort | evaluation of the 10 warning signs in primary and secondary immunodeficient patients |
| topic | primary immunodeficiency secondary immunodeficiency combined immunodeficiency 10 warning signs childhood |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.900055/full |
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