Prolonged FOS activity disrupts a global myogenic transcriptional program by altering 3D chromatin architecture in primary muscle progenitor cells

Prolonged FOS activity disrupts a global myogenic transcriptional program by altering 3D chromatin architecture in primary muscle progenitor cells

Abstract Background The AP-1 transcription factor, FBJ osteosarcoma oncogene (FOS), is induced in adult muscle satellite cells (SCs) within hours following muscle damage and is required for effective stem cell activation and muscle repair. However, why FOS is rapidly downregulated before SCs enter c...

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Bibliographic Details
Main Authors: A. Rasim Barutcu, Gabriel Elizalde, Alfredo E. Gonzalez, Kartik Soni, John L. Rinn, Amy J. Wagers, Albert E. Almada
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Skeletal Muscle
Subjects:
Muscle satellite cells
Muscle progenitor cells
FOS
AP-1
Myogenic differentiation
Hi-C
Online Access:https://doi.org/10.1186/s13395-022-00303-x

Internet

https://doi.org/10.1186/s13395-022-00303-x

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