Multisystem inflammatory syndrome in children related to COVID-19: Data from a Mexican national referral children's hospital
ObjectivesTo describe characteristics of patients with the pediatric inflammatory multisystem syndrome, temporally associated with SARS-CoV-2 (PIMS-TS)/multisystem inflammatory syndrome in children (MIS-C) and to identify factors associated with admission to the pediatric intensive care unit (PICU)...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.949965/full |
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| author | Héctor Menchaca-Aguayo Deshire Alpizar-Rodriguez Pamela Ramos-Tiñini Enrique Faugier-Fuentes |
| author_facet | Héctor Menchaca-Aguayo Deshire Alpizar-Rodriguez Pamela Ramos-Tiñini Enrique Faugier-Fuentes |
| author_sort | Héctor Menchaca-Aguayo |
| collection | DOAJ |
| description | ObjectivesTo describe characteristics of patients with the pediatric inflammatory multisystem syndrome, temporally associated with SARS-CoV-2 (PIMS-TS)/multisystem inflammatory syndrome in children (MIS-C) and to identify factors associated with admission to the pediatric intensive care unit (PICU) in the Mexican children without coronavirus disease 2019 (COVID-19) vaccination.MethodsThis was a cross-sectional study performed at Hospital Infantil de Mexico Federico Gomez, a referral children's hospital in Mexico. The study included all cases that met the criteria for PIMS-TS/MIS-C, unvaccinated, between March 2020 and January 2022. The primary outcome was the admission to PICU. Associations of PICU admission with demographic and clinical variables were estimated using logistic regression analyses.ResultsWe identified a total of 90 cases, with a median age of 7.5 years old, 47 (52.2%) girls. A previously healthy status was recorded in 76 (85%) children. All patients had positive PCR, serology test, or COVID-19 exposure. PICU admission was reported in 41 (45.6%) children. No deaths were reported. Patients received as treatment only corticosteroids in 53.3% of the cases. In univariable analyses, baseline factors associated with PICU admission were older age, hypotension or shock, positive PCR test, hypoalbuminemia, elevated procalcitonin, ferritin, and lymphopenia. Age, shock at admission, and hypoalbuminemia remained independently associated in the multivariable analysis adjusted by gender and previously healthy status.ConclusionWe found a high proportion of previously healthy children in patients with PIMS-TS/MIS-C in our center. Critical care attention was received by nearly half of the children. The main treatment used was steroids. Age, shock at admission, and hypoalbuminemia were factors associated with PICU admission. |
| first_indexed | 2024-12-10T20:03:00Z |
| format | Article |
| id | doaj.art-ff7f1c1233f9402b8f7443af9dcf34ea |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-10T20:03:00Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-ff7f1c1233f9402b8f7443af9dcf34ea2022-12-22T01:35:28ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-08-011010.3389/fped.2022.949965949965Multisystem inflammatory syndrome in children related to COVID-19: Data from a Mexican national referral children's hospitalHéctor Menchaca-Aguayo0Deshire Alpizar-Rodriguez1Pamela Ramos-Tiñini2Enrique Faugier-Fuentes3Pediatric Rheumatology Department, Hospital Infantil de México Federico Gómez, Mexico City, MexicoResearch Unit, Colegio Mexicano de Reumatología, Mexico City, MexicoPediatric Rheumatology Department, Hospital Infantil de México Federico Gómez, Mexico City, MexicoPediatric Rheumatology Department, Hospital Infantil de México Federico Gómez, Mexico City, MexicoObjectivesTo describe characteristics of patients with the pediatric inflammatory multisystem syndrome, temporally associated with SARS-CoV-2 (PIMS-TS)/multisystem inflammatory syndrome in children (MIS-C) and to identify factors associated with admission to the pediatric intensive care unit (PICU) in the Mexican children without coronavirus disease 2019 (COVID-19) vaccination.MethodsThis was a cross-sectional study performed at Hospital Infantil de Mexico Federico Gomez, a referral children's hospital in Mexico. The study included all cases that met the criteria for PIMS-TS/MIS-C, unvaccinated, between March 2020 and January 2022. The primary outcome was the admission to PICU. Associations of PICU admission with demographic and clinical variables were estimated using logistic regression analyses.ResultsWe identified a total of 90 cases, with a median age of 7.5 years old, 47 (52.2%) girls. A previously healthy status was recorded in 76 (85%) children. All patients had positive PCR, serology test, or COVID-19 exposure. PICU admission was reported in 41 (45.6%) children. No deaths were reported. Patients received as treatment only corticosteroids in 53.3% of the cases. In univariable analyses, baseline factors associated with PICU admission were older age, hypotension or shock, positive PCR test, hypoalbuminemia, elevated procalcitonin, ferritin, and lymphopenia. Age, shock at admission, and hypoalbuminemia remained independently associated in the multivariable analysis adjusted by gender and previously healthy status.ConclusionWe found a high proportion of previously healthy children in patients with PIMS-TS/MIS-C in our center. Critical care attention was received by nearly half of the children. The main treatment used was steroids. Age, shock at admission, and hypoalbuminemia were factors associated with PICU admission.https://www.frontiersin.org/articles/10.3389/fped.2022.949965/fullpediatric inflammatory multisystem syndrome temporally associated with COVID-19PIMS-TSMultisystem Inflammatory Syndrome in Children (MIS-C)SARS-CoV-2COVID-19epidemiology |
| spellingShingle | Héctor Menchaca-Aguayo Deshire Alpizar-Rodriguez Pamela Ramos-Tiñini Enrique Faugier-Fuentes Multisystem inflammatory syndrome in children related to COVID-19: Data from a Mexican national referral children's hospital Frontiers in Pediatrics pediatric inflammatory multisystem syndrome temporally associated with COVID-19 PIMS-TS Multisystem Inflammatory Syndrome in Children (MIS-C) SARS-CoV-2 COVID-19 epidemiology |
| title | Multisystem inflammatory syndrome in children related to COVID-19: Data from a Mexican national referral children's hospital |
| title_full | Multisystem inflammatory syndrome in children related to COVID-19: Data from a Mexican national referral children's hospital |
| title_fullStr | Multisystem inflammatory syndrome in children related to COVID-19: Data from a Mexican national referral children's hospital |
| title_full_unstemmed | Multisystem inflammatory syndrome in children related to COVID-19: Data from a Mexican national referral children's hospital |
| title_short | Multisystem inflammatory syndrome in children related to COVID-19: Data from a Mexican national referral children's hospital |
| title_sort | multisystem inflammatory syndrome in children related to covid 19 data from a mexican national referral children s hospital |
| topic | pediatric inflammatory multisystem syndrome temporally associated with COVID-19 PIMS-TS Multisystem Inflammatory Syndrome in Children (MIS-C) SARS-CoV-2 COVID-19 epidemiology |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.949965/full |
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