The Complex Link between Apoptosis and Autophagy: a Promising New Role for RB
ABSTRACT Physiological processes, as autophagy, proliferation and apoptosis are affected during carcinogenesis. Restoring cellular sensitivity to apoptotic stimuli, such as the antineoplastic cocktails, has been explored as a strategy to eliminate cancer cells. Autophagy, a physiological process of...
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Ciências
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| Series: | Anais da Academia Brasileira de Ciências |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602257&lng=en&tlng=en |
| _version_ | 1828530116611801088 |
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| author | JOÃO M.A. DELOU DEBORAH BIASOLI HELENA L. BORGES |
| author_facet | JOÃO M.A. DELOU DEBORAH BIASOLI HELENA L. BORGES |
| author_sort | JOÃO M.A. DELOU |
| collection | DOAJ |
| description | ABSTRACT Physiological processes, as autophagy, proliferation and apoptosis are affected during carcinogenesis. Restoring cellular sensitivity to apoptotic stimuli, such as the antineoplastic cocktails, has been explored as a strategy to eliminate cancer cells. Autophagy, a physiological process of recycling organelles and macromolecules can be deviated from homeostasis to support cancer cells survival, proliferation, escape from apoptosis, and therapy resistance. The relationship between autophagy and apoptosis is complex and many stimuli can induce both processes. Most chemotherapeutic agents induce autophagy and it is not clear whether and how this chemotherapy-induced autophagy might contribute to resistance to apoptosis. Here, we review current strategies to sensitize cancer cells by interfering with autophagy. Moreover, we discuss a new link between autophagy and apoptosis: the tumor suppressor retinoblastoma protein (RB). Inactivation of RB is one of the earliest and more frequent hallmarks of cancer transformation, known to control cell cycle progression and apoptosis. Therefore, understanding RB functions in controlling cell fate is essential for an effective translation of RB status in cancer samples to the clinical outcome. |
| first_indexed | 2024-12-11T22:18:34Z |
| format | Article |
| id | doaj.art-ff824e5254e74cf28764a5d80a417cc3 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-12-11T22:18:34Z |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-ff824e5254e74cf28764a5d80a417cc32022-12-22T00:48:31ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26908842257227510.1590/0001-3765201620160127S0001-37652016000602257The Complex Link between Apoptosis and Autophagy: a Promising New Role for RBJOÃO M.A. DELOUDEBORAH BIASOLIHELENA L. BORGESABSTRACT Physiological processes, as autophagy, proliferation and apoptosis are affected during carcinogenesis. Restoring cellular sensitivity to apoptotic stimuli, such as the antineoplastic cocktails, has been explored as a strategy to eliminate cancer cells. Autophagy, a physiological process of recycling organelles and macromolecules can be deviated from homeostasis to support cancer cells survival, proliferation, escape from apoptosis, and therapy resistance. The relationship between autophagy and apoptosis is complex and many stimuli can induce both processes. Most chemotherapeutic agents induce autophagy and it is not clear whether and how this chemotherapy-induced autophagy might contribute to resistance to apoptosis. Here, we review current strategies to sensitize cancer cells by interfering with autophagy. Moreover, we discuss a new link between autophagy and apoptosis: the tumor suppressor retinoblastoma protein (RB). Inactivation of RB is one of the earliest and more frequent hallmarks of cancer transformation, known to control cell cycle progression and apoptosis. Therefore, understanding RB functions in controlling cell fate is essential for an effective translation of RB status in cancer samples to the clinical outcome.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602257&lng=en&tlng=enretinoblastomaneoplasmautophagycell deathantineoplastic agents |
| spellingShingle | JOÃO M.A. DELOU DEBORAH BIASOLI HELENA L. BORGES The Complex Link between Apoptosis and Autophagy: a Promising New Role for RB Anais da Academia Brasileira de Ciências retinoblastoma neoplasm autophagy cell death antineoplastic agents |
| title | The Complex Link between Apoptosis and Autophagy: a Promising New Role for RB |
| title_full | The Complex Link between Apoptosis and Autophagy: a Promising New Role for RB |
| title_fullStr | The Complex Link between Apoptosis and Autophagy: a Promising New Role for RB |
| title_full_unstemmed | The Complex Link between Apoptosis and Autophagy: a Promising New Role for RB |
| title_short | The Complex Link between Apoptosis and Autophagy: a Promising New Role for RB |
| title_sort | complex link between apoptosis and autophagy a promising new role for rb |
| topic | retinoblastoma neoplasm autophagy cell death antineoplastic agents |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602257&lng=en&tlng=en |
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