Complement and hyper acute rejection
Organ transplantation has been a major development in clinical medicine but its success has been marred by the immune system′s capacity to respond to "non-self" cells and tissues. A full molecular understanding of this mechanism and the myriad triggers for immune rejection is ye...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2009-01-01
|
| Series: | Saudi Journal of Kidney Diseases and Transplantation |
| Subjects: | |
| Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2009;volume=20;issue=3;spage=362;epage=369;aulast=Al-Rabia |
| _version_ | 1818590911527911424 |
|---|---|
| author | Al-Rabia Mohammed |
| author_facet | Al-Rabia Mohammed |
| author_sort | Al-Rabia Mohammed |
| collection | DOAJ |
| description | Organ transplantation has been a major development in clinical medicine but its success has been marred by the immune system′s capacity to respond to "non-self" cells and tissues. A full molecular understanding of this mechanism and the myriad triggers for immune rejection is yet to be elucidated. Consequently, immunosuppressive drugs remain the mainstay of post-transplant ma-nagement; however, these interventions have side effects such as increased incidence of cancer, post-transplant lymphoproliferative disorders, susceptibility to infection if not managed appro-priately and the inconvenience to the patient of lifelong treatment. Novel therapeutic approaches based on molecular understanding of immunological processes are thus needed in this field. The notion that factors influencing successful transplants might be of use as therapeutic approaches is both scientifically and medically appealing. Recent developments in the understanding of successful transplants are expected to provide new opportunities for safer transplantation. This article reviews the present understanding of the molecular basis of rejection and the role of complement in this process as well as the possibility of generating "intelligent" therapy that better target crucial components of hyper-acute rejections. |
| first_indexed | 2024-12-16T10:04:04Z |
| format | Article |
| id | doaj.art-ff839e0cf5bc4b4a97de79d674046a52 |
| institution | Directory Open Access Journal |
| issn | 1319-2442 |
| language | English |
| last_indexed | 2024-12-16T10:04:04Z |
| publishDate | 2009-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Kidney Diseases and Transplantation |
| spelling | doaj.art-ff839e0cf5bc4b4a97de79d674046a522022-12-21T22:35:43ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422009-01-01203362369Complement and hyper acute rejectionAl-Rabia MohammedOrgan transplantation has been a major development in clinical medicine but its success has been marred by the immune system′s capacity to respond to "non-self" cells and tissues. A full molecular understanding of this mechanism and the myriad triggers for immune rejection is yet to be elucidated. Consequently, immunosuppressive drugs remain the mainstay of post-transplant ma-nagement; however, these interventions have side effects such as increased incidence of cancer, post-transplant lymphoproliferative disorders, susceptibility to infection if not managed appro-priately and the inconvenience to the patient of lifelong treatment. Novel therapeutic approaches based on molecular understanding of immunological processes are thus needed in this field. The notion that factors influencing successful transplants might be of use as therapeutic approaches is both scientifically and medically appealing. Recent developments in the understanding of successful transplants are expected to provide new opportunities for safer transplantation. This article reviews the present understanding of the molecular basis of rejection and the role of complement in this process as well as the possibility of generating "intelligent" therapy that better target crucial components of hyper-acute rejections.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2009;volume=20;issue=3;spage=362;epage=369;aulast=Al-RabiaOrgan TransplantationComplementHyper acute RejectionXenogeneicAllogeneicIsotypesEpitopes |
| spellingShingle | Al-Rabia Mohammed Complement and hyper acute rejection Saudi Journal of Kidney Diseases and Transplantation Organ Transplantation Complement Hyper acute Rejection Xenogeneic Allogeneic Isotypes Epitopes |
| title | Complement and hyper acute rejection |
| title_full | Complement and hyper acute rejection |
| title_fullStr | Complement and hyper acute rejection |
| title_full_unstemmed | Complement and hyper acute rejection |
| title_short | Complement and hyper acute rejection |
| title_sort | complement and hyper acute rejection |
| topic | Organ Transplantation Complement Hyper acute Rejection Xenogeneic Allogeneic Isotypes Epitopes |
| url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2009;volume=20;issue=3;spage=362;epage=369;aulast=Al-Rabia |
| work_keys_str_mv | AT alrabiamohammed complementandhyperacuterejection |