Serum Gamma-Glutamyltransferase, Daily Alcohol Consumption, and the Risk of Chronic Kidney Disease: The Kansai Healthcare Study
Background: Serum gamma-glutamyltransferase has been recognized as the risk factor of cardiovascular and metabolic diseases. However, the association between serum gamma-glutamyltransferase and the risk of chronic kidney disease is not well known, and no prospective studies have examined separately...
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| Format: | Article |
| Language: | English |
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Japan Epidemiological Association
2020-04-01
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| Series: | Journal of Epidemiology |
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| Online Access: | https://www.jstage.jst.go.jp/article/jea/30/4/30_JE20180240/_pdf |
| _version_ | 1819169534731354112 |
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| author | Mikiko Shibata Kyoko Kogawa Sato Shinichiro Uehara Hideo Koh Keiko Oue Hiroshi Kambe Michio Morimoto Tomoshige Hayashi |
| author_facet | Mikiko Shibata Kyoko Kogawa Sato Shinichiro Uehara Hideo Koh Keiko Oue Hiroshi Kambe Michio Morimoto Tomoshige Hayashi |
| author_sort | Mikiko Shibata |
| collection | DOAJ |
| description | Background: Serum gamma-glutamyltransferase has been recognized as the risk factor of cardiovascular and metabolic diseases. However, the association between serum gamma-glutamyltransferase and the risk of chronic kidney disease is not well known, and no prospective studies have examined separately the relationship of serum gamma-glutamyltransferase with the risk of proteinuria versus that of low estimated glomerular filtration rate (eGFR). Methods: We prospectively followed 9,341 Japanese men who did not have low eGFR, proteinuria, or diabetes, and did not take antihypertensive medications at entry for the analysis of proteinuria, and we followed 9,299 men for the analysis of low eGFR. We defined “persistent proteinuria” as proteinuria detected two or more times consecutively and persistently as ≥1+ on urine dipstick at the annual check-up until the end of follow-up. Low eGFR was defined as eGFR <60 mL/min/1.73 m2. Results: During the 11-year observation period, 151 men developed persistent proteinuria and 1,276 men developed low eGFR. In multivariate models, the highest quartile (≥71 IU/L) of serum gamma-glutamyltransferase was independently related to the development of persistent proteinuria (hazard ratio 3.39; 95% confidence interval, 1.92–5.97) compared with the lowest quartile (≤25 IU/L). In joint analysis of alcohol consumption and serum gamma-glutamyltransferase, non-drinkers in the highest tertile (≥58 IU/L) of serum gamma-glutamyltransferase had the highest risk of persistent proteinuria. However, there was no association between serum gamma-glutamyltransferase and low eGFR. Conclusion: In middle-aged Japanese men, elevated serum gamma-glutamyltransferase was independently associated with future persistent proteinuria, but not with low eGFR. |
| first_indexed | 2024-12-22T19:21:02Z |
| format | Article |
| id | doaj.art-ff842533d9cd4ac3ab3ee0b471e92012 |
| institution | Directory Open Access Journal |
| issn | 0917-5040 1349-9092 |
| language | English |
| last_indexed | 2024-12-22T19:21:02Z |
| publishDate | 2020-04-01 |
| publisher | Japan Epidemiological Association |
| record_format | Article |
| series | Journal of Epidemiology |
| spelling | doaj.art-ff842533d9cd4ac3ab3ee0b471e920122022-12-21T18:15:23ZengJapan Epidemiological AssociationJournal of Epidemiology0917-50401349-90922020-04-0130416316910.2188/jea.JE20180240Serum Gamma-Glutamyltransferase, Daily Alcohol Consumption, and the Risk of Chronic Kidney Disease: The Kansai Healthcare StudyMikiko Shibata0Kyoko Kogawa Sato1Shinichiro Uehara2Hideo Koh3Keiko Oue4Hiroshi Kambe5Michio Morimoto6Tomoshige Hayashi7Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, JapanPreventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, JapanPreventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, JapanHematology, Osaka City University Graduate School of Medicine, Osaka, JapanPreventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, JapanKansai Health Administration Center, Nippon Telegraph and Telephone West Corporation, Osaka, JapanKansai Health Administration Center, Nippon Telegraph and Telephone West Corporation, Osaka, JapanPreventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, JapanBackground: Serum gamma-glutamyltransferase has been recognized as the risk factor of cardiovascular and metabolic diseases. However, the association between serum gamma-glutamyltransferase and the risk of chronic kidney disease is not well known, and no prospective studies have examined separately the relationship of serum gamma-glutamyltransferase with the risk of proteinuria versus that of low estimated glomerular filtration rate (eGFR). Methods: We prospectively followed 9,341 Japanese men who did not have low eGFR, proteinuria, or diabetes, and did not take antihypertensive medications at entry for the analysis of proteinuria, and we followed 9,299 men for the analysis of low eGFR. We defined “persistent proteinuria” as proteinuria detected two or more times consecutively and persistently as ≥1+ on urine dipstick at the annual check-up until the end of follow-up. Low eGFR was defined as eGFR <60 mL/min/1.73 m2. Results: During the 11-year observation period, 151 men developed persistent proteinuria and 1,276 men developed low eGFR. In multivariate models, the highest quartile (≥71 IU/L) of serum gamma-glutamyltransferase was independently related to the development of persistent proteinuria (hazard ratio 3.39; 95% confidence interval, 1.92–5.97) compared with the lowest quartile (≤25 IU/L). In joint analysis of alcohol consumption and serum gamma-glutamyltransferase, non-drinkers in the highest tertile (≥58 IU/L) of serum gamma-glutamyltransferase had the highest risk of persistent proteinuria. However, there was no association between serum gamma-glutamyltransferase and low eGFR. Conclusion: In middle-aged Japanese men, elevated serum gamma-glutamyltransferase was independently associated with future persistent proteinuria, but not with low eGFR.https://www.jstage.jst.go.jp/article/jea/30/4/30_JE20180240/_pdfgamma-glutamyltransferaseproteinuriachronic kidney diseaseprospective cohort studyepidemiology |
| spellingShingle | Mikiko Shibata Kyoko Kogawa Sato Shinichiro Uehara Hideo Koh Keiko Oue Hiroshi Kambe Michio Morimoto Tomoshige Hayashi Serum Gamma-Glutamyltransferase, Daily Alcohol Consumption, and the Risk of Chronic Kidney Disease: The Kansai Healthcare Study Journal of Epidemiology gamma-glutamyltransferase proteinuria chronic kidney disease prospective cohort study epidemiology |
| title | Serum Gamma-Glutamyltransferase, Daily Alcohol Consumption, and the Risk of Chronic Kidney Disease: The Kansai Healthcare Study |
| title_full | Serum Gamma-Glutamyltransferase, Daily Alcohol Consumption, and the Risk of Chronic Kidney Disease: The Kansai Healthcare Study |
| title_fullStr | Serum Gamma-Glutamyltransferase, Daily Alcohol Consumption, and the Risk of Chronic Kidney Disease: The Kansai Healthcare Study |
| title_full_unstemmed | Serum Gamma-Glutamyltransferase, Daily Alcohol Consumption, and the Risk of Chronic Kidney Disease: The Kansai Healthcare Study |
| title_short | Serum Gamma-Glutamyltransferase, Daily Alcohol Consumption, and the Risk of Chronic Kidney Disease: The Kansai Healthcare Study |
| title_sort | serum gamma glutamyltransferase daily alcohol consumption and the risk of chronic kidney disease the kansai healthcare study |
| topic | gamma-glutamyltransferase proteinuria chronic kidney disease prospective cohort study epidemiology |
| url | https://www.jstage.jst.go.jp/article/jea/30/4/30_JE20180240/_pdf |
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