p53 restoration in small cell lung cancer identifies a latent cyclophilin-dependent necrosis mechanism

p53 restoration in small cell lung cancer identifies a latent cyclophilin-dependent necrosis mechanism

Abstract The p53 tumor suppressor regulates multiple context-dependent tumor suppressive programs. Although p53 is mutated in ~90% of small cell lung cancer (SCLC) tumors, how p53 mediates tumor suppression in this context is unknown. Here, using a mouse model of SCLC in which endogenous p53 express...

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Bibliographic Details
Main Authors: Jonuelle Acosta, Qinglan Li, Nelson F. Freeburg, Nivitha Murali, Alexandra Indeglia, Grant P. Grothusen, Michelle Cicchini, Hung Mai, Amy C. Gladstein, Keren M. Adler, Katherine R. Doerig, Jinyang Li, Miguel Ruiz-Torres, Kimberly L. Manning, Ben Z. Stanger, Luca Busino, Maureen Murphy, Liling Wan, David M. Feldser
Format: Article
Language:English
Published: Nature Portfolio 2023-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40161-9

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