On the complexity of miRNA-mediated regulation in plants: novel insights into the genomic organization of plant miRNAs
<p>Abstract</p> <p>MicroRNAs (miRNAs) are endogenous small non-coding RNAs of about 20–24 nt, known to play key roles in post-transcriptional gene regulation, that can be coded either by intergenic or intragenic loci. Intragenic (exonic and intronic) miRNAs can exert a role in the...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-05-01
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| Series: | Biology Direct |
| Subjects: | |
| Online Access: | http://www.biology-direct.com/content/7/1/15 |
| _version_ | 1818664991754027008 |
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| author | Colaiacovo Moreno Lamontanara Antonella Bernardo Letizia Alberici Renzo Crosatti Cristina Giusti Lorenzo Cattivelli Luigi Faccioli Primetta |
| author_facet | Colaiacovo Moreno Lamontanara Antonella Bernardo Letizia Alberici Renzo Crosatti Cristina Giusti Lorenzo Cattivelli Luigi Faccioli Primetta |
| author_sort | Colaiacovo Moreno |
| collection | DOAJ |
| description | <p>Abstract</p> <p>MicroRNAs (miRNAs) are endogenous small non-coding RNAs of about 20–24 nt, known to play key roles in post-transcriptional gene regulation, that can be coded either by intergenic or intragenic loci. Intragenic (exonic and intronic) miRNAs can exert a role in the transcriptional regulation and RNA processing of their host gene. Moreover, the possibility that the biogenesis of exonic miRNAs could destabilize the corresponding protein-coding transcript and reduce protein synthesis makes their characterization very intriguing and suggests a possible novel mechanism of post-transcriptional regulation of gene expression.</p> <p>This work was designed to carry out the computational identification of putative exonic miRNAs in 30 plant species and the analysis of possible mechanisms involved in their regulation.</p> <p>The results obtained represent a useful starting point for future studies on the complex networks involved in microRNA-mediated gene regulation in plants.</p> |
| first_indexed | 2024-12-17T05:41:32Z |
| format | Article |
| id | doaj.art-ff84e10dde874de3aaececb3a9eacc0b |
| institution | Directory Open Access Journal |
| issn | 1745-6150 |
| language | English |
| last_indexed | 2024-12-17T05:41:32Z |
| publishDate | 2012-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology Direct |
| spelling | doaj.art-ff84e10dde874de3aaececb3a9eacc0b2022-12-21T22:01:26ZengBMCBiology Direct1745-61502012-05-01711510.1186/1745-6150-7-15On the complexity of miRNA-mediated regulation in plants: novel insights into the genomic organization of plant miRNAsColaiacovo MorenoLamontanara AntonellaBernardo LetiziaAlberici RenzoCrosatti CristinaGiusti LorenzoCattivelli LuigiFaccioli Primetta<p>Abstract</p> <p>MicroRNAs (miRNAs) are endogenous small non-coding RNAs of about 20–24 nt, known to play key roles in post-transcriptional gene regulation, that can be coded either by intergenic or intragenic loci. Intragenic (exonic and intronic) miRNAs can exert a role in the transcriptional regulation and RNA processing of their host gene. Moreover, the possibility that the biogenesis of exonic miRNAs could destabilize the corresponding protein-coding transcript and reduce protein synthesis makes their characterization very intriguing and suggests a possible novel mechanism of post-transcriptional regulation of gene expression.</p> <p>This work was designed to carry out the computational identification of putative exonic miRNAs in 30 plant species and the analysis of possible mechanisms involved in their regulation.</p> <p>The results obtained represent a useful starting point for future studies on the complex networks involved in microRNA-mediated gene regulation in plants.</p>http://www.biology-direct.com/content/7/1/15Gene regulationExonic miRNAmiRNA self regulationPlants |
| spellingShingle | Colaiacovo Moreno Lamontanara Antonella Bernardo Letizia Alberici Renzo Crosatti Cristina Giusti Lorenzo Cattivelli Luigi Faccioli Primetta On the complexity of miRNA-mediated regulation in plants: novel insights into the genomic organization of plant miRNAs Biology Direct Gene regulation Exonic miRNA miRNA self regulation Plants |
| title | On the complexity of miRNA-mediated regulation in plants: novel insights into the genomic organization of plant miRNAs |
| title_full | On the complexity of miRNA-mediated regulation in plants: novel insights into the genomic organization of plant miRNAs |
| title_fullStr | On the complexity of miRNA-mediated regulation in plants: novel insights into the genomic organization of plant miRNAs |
| title_full_unstemmed | On the complexity of miRNA-mediated regulation in plants: novel insights into the genomic organization of plant miRNAs |
| title_short | On the complexity of miRNA-mediated regulation in plants: novel insights into the genomic organization of plant miRNAs |
| title_sort | on the complexity of mirna mediated regulation in plants novel insights into the genomic organization of plant mirnas |
| topic | Gene regulation Exonic miRNA miRNA self regulation Plants |
| url | http://www.biology-direct.com/content/7/1/15 |
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