Datasets on the genomic positions of the MLL1 morphemes, the ZFP57 binding site, and ZFBS-Morph overlaps in the build mm9 of the mouse genome
While MLL1 activates gene expression in most tissues, ZFP57 represses transcription. MLL1 selectively interacts with a group of nonmethylated DNA sequences known as the MLL1 morphemes. ZFP57 associates with a methylated hexamer (ZFBS), dispersed in the genomic DNA segments known as Imprinted Control...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-08-01
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| Series: | Data in Brief |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S235234091730241X |
| _version_ | 1818178765137641472 |
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| author | Minou Bina Phillip Wyss Xiaohui C. Song |
| author_facet | Minou Bina Phillip Wyss Xiaohui C. Song |
| author_sort | Minou Bina |
| collection | DOAJ |
| description | While MLL1 activates gene expression in most tissues, ZFP57 represses transcription. MLL1 selectively interacts with a group of nonmethylated DNA sequences known as the MLL1 morphemes. ZFP57 associates with a methylated hexamer (ZFBS), dispersed in the genomic DNA segments known as Imprinted Control Regions (ICRs) and germline Differentially Methylated Regions (gDMRs), to maintain allele-specific gene repression. We have identified a set of composite DNA elements (ZFBS-Morph overlaps) that provides the sequence context of ZFBS in the canonical ICRs/gDMRs. This report provides tables listing the nucleotide sequences of the MLL1 morphemes and ZFBS-Morph overlaps. The report also offers links to the data repository at Purdue University, for downloading the positions of the MLL1 morphemes, the ZFP57 binding site, and the ZFBS-Morph overlaps in the mouse genome. Keywords: CpG-rich motifs, Gene regulation, Genomic imprinting, KMT2A, MLL1 morphemes, Mouse genome, ZFP57 binding site |
| first_indexed | 2024-12-11T20:53:10Z |
| format | Article |
| id | doaj.art-ff8577ba5eda4431b993d6c7bcb8b99e |
| institution | Directory Open Access Journal |
| issn | 2352-3409 |
| language | English |
| last_indexed | 2024-12-11T20:53:10Z |
| publishDate | 2017-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Data in Brief |
| spelling | doaj.art-ff8577ba5eda4431b993d6c7bcb8b99e2022-12-22T00:51:10ZengElsevierData in Brief2352-34092017-08-0113202207Datasets on the genomic positions of the MLL1 morphemes, the ZFP57 binding site, and ZFBS-Morph overlaps in the build mm9 of the mouse genomeMinou Bina0Phillip Wyss1Xiaohui C. Song2Purdue University, Department of Chemistry, West Lafayette, IN 47907, USA; Corresponding author.Purdue University, Department of Chemistry, West Lafayette, IN 47907, USAInformation Technology at Purdue University, West Lafayette, IN 47907, USAWhile MLL1 activates gene expression in most tissues, ZFP57 represses transcription. MLL1 selectively interacts with a group of nonmethylated DNA sequences known as the MLL1 morphemes. ZFP57 associates with a methylated hexamer (ZFBS), dispersed in the genomic DNA segments known as Imprinted Control Regions (ICRs) and germline Differentially Methylated Regions (gDMRs), to maintain allele-specific gene repression. We have identified a set of composite DNA elements (ZFBS-Morph overlaps) that provides the sequence context of ZFBS in the canonical ICRs/gDMRs. This report provides tables listing the nucleotide sequences of the MLL1 morphemes and ZFBS-Morph overlaps. The report also offers links to the data repository at Purdue University, for downloading the positions of the MLL1 morphemes, the ZFP57 binding site, and the ZFBS-Morph overlaps in the mouse genome. Keywords: CpG-rich motifs, Gene regulation, Genomic imprinting, KMT2A, MLL1 morphemes, Mouse genome, ZFP57 binding sitehttp://www.sciencedirect.com/science/article/pii/S235234091730241X |
| spellingShingle | Minou Bina Phillip Wyss Xiaohui C. Song Datasets on the genomic positions of the MLL1 morphemes, the ZFP57 binding site, and ZFBS-Morph overlaps in the build mm9 of the mouse genome Data in Brief |
| title | Datasets on the genomic positions of the MLL1 morphemes, the ZFP57 binding site, and ZFBS-Morph overlaps in the build mm9 of the mouse genome |
| title_full | Datasets on the genomic positions of the MLL1 morphemes, the ZFP57 binding site, and ZFBS-Morph overlaps in the build mm9 of the mouse genome |
| title_fullStr | Datasets on the genomic positions of the MLL1 morphemes, the ZFP57 binding site, and ZFBS-Morph overlaps in the build mm9 of the mouse genome |
| title_full_unstemmed | Datasets on the genomic positions of the MLL1 morphemes, the ZFP57 binding site, and ZFBS-Morph overlaps in the build mm9 of the mouse genome |
| title_short | Datasets on the genomic positions of the MLL1 morphemes, the ZFP57 binding site, and ZFBS-Morph overlaps in the build mm9 of the mouse genome |
| title_sort | datasets on the genomic positions of the mll1 morphemes the zfp57 binding site and zfbs morph overlaps in the build mm9 of the mouse genome |
| url | http://www.sciencedirect.com/science/article/pii/S235234091730241X |
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