CLINICAL MANIFESTATIONS OF VASCULITIS AT THE ONSET OF MULTIPLE MYELOMA
The paper describes two patients (a 50-year woman and a 72-year man) in whom the clinical manifestations of ulceronecrotic vasculitis had long preceded before the diagnosis of multiple myeloma was made. In the former, monoclonal cryoglobulinemia type I induced ulcerative lesions with the development...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2010-02-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/1249 |
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| author | V I Vasil'ev V R Gorodetskiy S Kh Sedyshev N A Probatova A I Pavlovskaya M Yu Varlamova S G Pal'shina A L Logunov O A Logvinenko E V Sokol E L Nasonov V I Vasilyev V R Gorodetsky S Kh Sedyshev N A Probatova A I Pavlovskaya M Yu Varlamova S G Palshina A L Logunov O Logvinenko E V Sokol E L Nasonov |
| author_facet | V I Vasil'ev V R Gorodetskiy S Kh Sedyshev N A Probatova A I Pavlovskaya M Yu Varlamova S G Pal'shina A L Logunov O A Logvinenko E V Sokol E L Nasonov V I Vasilyev V R Gorodetsky S Kh Sedyshev N A Probatova A I Pavlovskaya M Yu Varlamova S G Palshina A L Logunov O Logvinenko E V Sokol E L Nasonov |
| author_sort | V I Vasil'ev |
| collection | DOAJ |
| description | The paper describes two patients (a 50-year woman and a 72-year man) in whom the clinical manifestations of ulceronecrotic vasculitis had long preceded before the diagnosis of multiple myeloma was made. In the former, monoclonal cryoglobulinemia type I induced ulcerative lesions with the development of dry toe gangrene and paraproteinemic renal lesion. In the latter, ulceronecrotic vasculitis with the development of dry toe gangrene was a manifestation of monoclonal paraproteinemia without signs of cryoglobulinemia. Both patients were found to have monoclonal blood secretion (РIgGλ и РIgGκ) and urine Bence Jones protein (BJλ+BJκ, BJκ) in the absence of immunological markers of vasculitis developing in patients with rheumatic diseases. Immunochemical study of serum/urine and, when monoclonal secretion of PIg+BJ is detected, further examination for plasma cell dyscrasia should be performed in all cases of vascular disorders (cold allergy, Raynaud's syndrome, purpura, ulcers of cruses, and gangrene of distal phalanxes of the hands/feet) in patients with atypical vasculitis. The timely immunochemical study of blood and urine will make it possible to diagnose plasma cell dyscrasia (different types of myelomic disease, Waldenstrцm macroglobulinemia, primary amyloidosis) at the early stage of the disease and to rule out unjustifiably diagnosed vasculitis in patients with atypical vascular lesions. |
| first_indexed | 2024-04-09T22:26:51Z |
| format | Article |
| id | doaj.art-ff892293ae5846bcab70ea94414dc101 |
| institution | Directory Open Access Journal |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| last_indexed | 2024-04-09T22:26:51Z |
| publishDate | 2010-02-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj.art-ff892293ae5846bcab70ea94414dc1012023-03-22T13:45:45ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922010-02-01481818710.14412/1995-4484-2010-14101189CLINICAL MANIFESTATIONS OF VASCULITIS AT THE ONSET OF MULTIPLE MYELOMAV I Vasil'evV R GorodetskiyS Kh SedyshevN A ProbatovaA I PavlovskayaM Yu VarlamovaS G Pal'shinaA L LogunovO A LogvinenkoE V SokolE L NasonovV I VasilyevV R GorodetskyS Kh SedyshevN A ProbatovaA I PavlovskayaM Yu VarlamovaS G PalshinaA L LogunovO LogvinenkoE V SokolE L NasonovThe paper describes two patients (a 50-year woman and a 72-year man) in whom the clinical manifestations of ulceronecrotic vasculitis had long preceded before the diagnosis of multiple myeloma was made. In the former, monoclonal cryoglobulinemia type I induced ulcerative lesions with the development of dry toe gangrene and paraproteinemic renal lesion. In the latter, ulceronecrotic vasculitis with the development of dry toe gangrene was a manifestation of monoclonal paraproteinemia without signs of cryoglobulinemia. Both patients were found to have monoclonal blood secretion (РIgGλ и РIgGκ) and urine Bence Jones protein (BJλ+BJκ, BJκ) in the absence of immunological markers of vasculitis developing in patients with rheumatic diseases. Immunochemical study of serum/urine and, when monoclonal secretion of PIg+BJ is detected, further examination for plasma cell dyscrasia should be performed in all cases of vascular disorders (cold allergy, Raynaud's syndrome, purpura, ulcers of cruses, and gangrene of distal phalanxes of the hands/feet) in patients with atypical vasculitis. The timely immunochemical study of blood and urine will make it possible to diagnose plasma cell dyscrasia (different types of myelomic disease, Waldenstrцm macroglobulinemia, primary amyloidosis) at the early stage of the disease and to rule out unjustifiably diagnosed vasculitis in patients with atypical vascular lesions.https://rsp.mediar-press.net/rsp/article/view/1249myelomavasculitisimmunoglobulinscryoglobulinssepsis |
| spellingShingle | V I Vasil'ev V R Gorodetskiy S Kh Sedyshev N A Probatova A I Pavlovskaya M Yu Varlamova S G Pal'shina A L Logunov O A Logvinenko E V Sokol E L Nasonov V I Vasilyev V R Gorodetsky S Kh Sedyshev N A Probatova A I Pavlovskaya M Yu Varlamova S G Palshina A L Logunov O Logvinenko E V Sokol E L Nasonov CLINICAL MANIFESTATIONS OF VASCULITIS AT THE ONSET OF MULTIPLE MYELOMA Научно-практическая ревматология myeloma vasculitis immunoglobulins cryoglobulins sepsis |
| title | CLINICAL MANIFESTATIONS OF VASCULITIS AT THE ONSET OF MULTIPLE MYELOMA |
| title_full | CLINICAL MANIFESTATIONS OF VASCULITIS AT THE ONSET OF MULTIPLE MYELOMA |
| title_fullStr | CLINICAL MANIFESTATIONS OF VASCULITIS AT THE ONSET OF MULTIPLE MYELOMA |
| title_full_unstemmed | CLINICAL MANIFESTATIONS OF VASCULITIS AT THE ONSET OF MULTIPLE MYELOMA |
| title_short | CLINICAL MANIFESTATIONS OF VASCULITIS AT THE ONSET OF MULTIPLE MYELOMA |
| title_sort | clinical manifestations of vasculitis at the onset of multiple myeloma |
| topic | myeloma vasculitis immunoglobulins cryoglobulins sepsis |
| url | https://rsp.mediar-press.net/rsp/article/view/1249 |
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