Human γδ T-Cells: From Surface Receptors to the Therapy of High-Risk Leukemias

Human γδ T-Cells: From Surface Receptors to the Therapy of High-Risk Leukemias

γδ T lymphocytes are potent effector cells, capable of efficiently killing tumor and leukemia cells. Their activation is mediated by γδ T-cell receptor (TCR) and by activating receptors shared with NK cells (e.g., NKG2D and DNAM-1). γδ T-cell triggering occurs upon interaction with specific ligands,...

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Bibliographic Details
Main Authors: Vito Pistoia, Nicola Tumino, Paola Vacca, Irene Veneziani, Alessandro Moretta, Franco Locatelli, Lorenzo Moretta
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Immunology
Subjects:
γδ T-cells
receptors
hematopoietic stem cells
HLA-haploidentical transplantation
αβ T-cell
B-cell depletion
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00984/full

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