Autophagic degradation of focal adhesions underlies metastatic cancer dissemination
Autophagy inhibition is being evaluated as a novel therapeutic strategy in multiple tumor types, but little is known about its implications for metastatic dissemination. We recently reported that autophagic degradation of paxillin through direct interaction with the autophagy protein LC3B is require...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2017-03-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2016.1198299 |
| _version_ | 1797677252266164224 |
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| author | Marina N. Sharifi Erin E. Mowers Kay F. Macleod |
| author_facet | Marina N. Sharifi Erin E. Mowers Kay F. Macleod |
| author_sort | Marina N. Sharifi |
| collection | DOAJ |
| description | Autophagy inhibition is being evaluated as a novel therapeutic strategy in multiple tumor types, but little is known about its implications for metastatic dissemination. We recently reported that autophagic degradation of paxillin through direct interaction with the autophagy protein LC3B is required for focal adhesion disassembly, Src-stimulated tumor cell motility, and metastasis. |
| first_indexed | 2024-03-11T22:42:22Z |
| format | Article |
| id | doaj.art-ff8f41993646426abf669b6664eecfdd |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:42:22Z |
| publishDate | 2017-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-ff8f41993646426abf669b6664eecfdd2023-09-22T09:10:57ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562017-03-014210.1080/23723556.2016.11982991198299Autophagic degradation of focal adhesions underlies metastatic cancer disseminationMarina N. Sharifi0Erin E. Mowers1Kay F. Macleod2The University of ChicagoThe University of ChicagoThe University of ChicagoAutophagy inhibition is being evaluated as a novel therapeutic strategy in multiple tumor types, but little is known about its implications for metastatic dissemination. We recently reported that autophagic degradation of paxillin through direct interaction with the autophagy protein LC3B is required for focal adhesion disassembly, Src-stimulated tumor cell motility, and metastasis.http://dx.doi.org/10.1080/23723556.2016.1198299autophagycell motilitymetastasispaxillinsrc |
| spellingShingle | Marina N. Sharifi Erin E. Mowers Kay F. Macleod Autophagic degradation of focal adhesions underlies metastatic cancer dissemination Molecular & Cellular Oncology autophagy cell motility metastasis paxillin src |
| title | Autophagic degradation of focal adhesions underlies metastatic cancer dissemination |
| title_full | Autophagic degradation of focal adhesions underlies metastatic cancer dissemination |
| title_fullStr | Autophagic degradation of focal adhesions underlies metastatic cancer dissemination |
| title_full_unstemmed | Autophagic degradation of focal adhesions underlies metastatic cancer dissemination |
| title_short | Autophagic degradation of focal adhesions underlies metastatic cancer dissemination |
| title_sort | autophagic degradation of focal adhesions underlies metastatic cancer dissemination |
| topic | autophagy cell motility metastasis paxillin src |
| url | http://dx.doi.org/10.1080/23723556.2016.1198299 |
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