Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11843 |
| _version_ | 1819040358192906240 |
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| author | Mitchell J. Machiela Weiyin Zhou Eric Karlins Joshua N. Sampson Neal D. Freedman Qi Yang Belynda Hicks Casey Dagnall Christopher Hautman Kevin B. Jacobs Christian C. Abnet Melinda C. Aldrich Christopher Amos Laufey T. Amundadottir Alan A. Arslan Laura E. Beane-Freeman Sonja I. Berndt Amanda Black William J. Blot Cathryn H. Bock Paige M. Bracci Louise A. Brinton H Bas Bueno-de-Mesquita Laurie Burdett Julie E. Buring Mary A. Butler Federico Canzian Tania Carreón Kari G. Chaffee I-Shou Chang Nilanjan Chatterjee Chu Chen Constance Chen Kexin Chen Charles C. Chung Linda S. Cook Marta Crous Bou Michael Cullen Faith G. Davis Immaculata De Vivo Ti Ding Jennifer Doherty Eric J. Duell Caroline G. Epstein Jin-Hu Fan Jonine D. Figueroa Joseph F. Fraumeni Christine M. Friedenreich Charles S. Fuchs Steven Gallinger Yu-Tang Gao Susan M. Gapstur Montserrat Garcia-Closas Mia M. Gaudet J. Michael Gaziano Graham G. Giles Elizabeth M. Gillanders Edward L. Giovannucci Lynn Goldin Alisa M. Goldstein Christopher A. Haiman Goran Hallmans Susan E. Hankinson Curtis C. Harris Roger Henriksson Elizabeth A. Holly Yun-Chul Hong Robert N. Hoover Chao A. Hsiung Nan Hu Wei Hu David J. Hunter Amy Hutchinson Mazda Jenab Christoffer Johansen Kay-Tee Khaw Hee Nam Kim Yeul Hong Kim Young Tae Kim Alison P. Klein Robert Klein Woon-Puay Koh Laurence N. Kolonel Charles Kooperberg Peter Kraft Vittorio Krogh Robert C. Kurtz Andrea LaCroix Qing Lan Maria Teresa Landi Loic Le Marchand Donghui Li Xiaolin Liang Linda M. Liao Dongxin Lin Jianjun Liu Jolanta Lissowska Lingeng Lu Anthony M. Magliocco Nuria Malats Keitaro Matsuo Lorna H. McNeill Robert R. McWilliams Beatrice S. Melin Lisa Mirabello Lee Moore Sara H. Olson Irene Orlow Jae Yong Park Ana Patiño-Garcia Beata Peplonska Ulrike Peters Gloria M. Petersen Loreall Pooler Jennifer Prescott Ludmila Prokunina-Olsson Mark P. Purdue You-Lin Qiao Preetha Rajaraman Francisco X. Real Elio Riboli Harvey A. Risch Benjamin Rodriguez-Santiago Avima M. Ruder Sharon A. Savage Fredrick Schumacher Ann G. Schwartz Kendra L. Schwartz Adeline Seow Veronica Wendy Setiawan Gianluca Severi Hongbing Shen Xin Sheng Min-Ho Shin Xiao-Ou Shu Debra T. Silverman Margaret R. Spitz Victoria L. Stevens Rachael Stolzenberg-Solomon Daniel Stram Ze-Zhong Tang Philip R. Taylor Lauren R. Teras Geoffrey S. Tobias David Van Den Berg Kala Visvanathan Sholom Wacholder Jiu-Cun Wang Zhaoming Wang Nicolas Wentzensen William Wheeler Emily White John K. Wiencke Brian M. Wolpin Maria Pik Wong Chen Wu Tangchun Wu Xifeng Wu Yi-Long Wu Jay S. Wunder Lucy Xia Hannah P. Yang Pan-Chyr Yang Kai Yu Krista A. Zanetti Anne Zeleniuch-Jacquotte Wei Zheng Baosen Zhou Regina G. Ziegler Luis A. Perez-Jurado Neil E. Caporaso Nathaniel Rothman Margaret Tucker Michael C. Dean Meredith Yeager Stephen J. Chanock |
| author_facet | Mitchell J. Machiela Weiyin Zhou Eric Karlins Joshua N. Sampson Neal D. Freedman Qi Yang Belynda Hicks Casey Dagnall Christopher Hautman Kevin B. Jacobs Christian C. Abnet Melinda C. Aldrich Christopher Amos Laufey T. Amundadottir Alan A. Arslan Laura E. Beane-Freeman Sonja I. Berndt Amanda Black William J. Blot Cathryn H. Bock Paige M. Bracci Louise A. Brinton H Bas Bueno-de-Mesquita Laurie Burdett Julie E. Buring Mary A. Butler Federico Canzian Tania Carreón Kari G. Chaffee I-Shou Chang Nilanjan Chatterjee Chu Chen Constance Chen Kexin Chen Charles C. Chung Linda S. Cook Marta Crous Bou Michael Cullen Faith G. Davis Immaculata De Vivo Ti Ding Jennifer Doherty Eric J. Duell Caroline G. Epstein Jin-Hu Fan Jonine D. Figueroa Joseph F. Fraumeni Christine M. Friedenreich Charles S. Fuchs Steven Gallinger Yu-Tang Gao Susan M. Gapstur Montserrat Garcia-Closas Mia M. Gaudet J. Michael Gaziano Graham G. Giles Elizabeth M. Gillanders Edward L. Giovannucci Lynn Goldin Alisa M. Goldstein Christopher A. Haiman Goran Hallmans Susan E. Hankinson Curtis C. Harris Roger Henriksson Elizabeth A. Holly Yun-Chul Hong Robert N. Hoover Chao A. Hsiung Nan Hu Wei Hu David J. Hunter Amy Hutchinson Mazda Jenab Christoffer Johansen Kay-Tee Khaw Hee Nam Kim Yeul Hong Kim Young Tae Kim Alison P. Klein Robert Klein Woon-Puay Koh Laurence N. Kolonel Charles Kooperberg Peter Kraft Vittorio Krogh Robert C. Kurtz Andrea LaCroix Qing Lan Maria Teresa Landi Loic Le Marchand Donghui Li Xiaolin Liang Linda M. Liao Dongxin Lin Jianjun Liu Jolanta Lissowska Lingeng Lu Anthony M. Magliocco Nuria Malats Keitaro Matsuo Lorna H. McNeill Robert R. McWilliams Beatrice S. Melin Lisa Mirabello Lee Moore Sara H. Olson Irene Orlow Jae Yong Park Ana Patiño-Garcia Beata Peplonska Ulrike Peters Gloria M. Petersen Loreall Pooler Jennifer Prescott Ludmila Prokunina-Olsson Mark P. Purdue You-Lin Qiao Preetha Rajaraman Francisco X. Real Elio Riboli Harvey A. Risch Benjamin Rodriguez-Santiago Avima M. Ruder Sharon A. Savage Fredrick Schumacher Ann G. Schwartz Kendra L. Schwartz Adeline Seow Veronica Wendy Setiawan Gianluca Severi Hongbing Shen Xin Sheng Min-Ho Shin Xiao-Ou Shu Debra T. Silverman Margaret R. Spitz Victoria L. Stevens Rachael Stolzenberg-Solomon Daniel Stram Ze-Zhong Tang Philip R. Taylor Lauren R. Teras Geoffrey S. Tobias David Van Den Berg Kala Visvanathan Sholom Wacholder Jiu-Cun Wang Zhaoming Wang Nicolas Wentzensen William Wheeler Emily White John K. Wiencke Brian M. Wolpin Maria Pik Wong Chen Wu Tangchun Wu Xifeng Wu Yi-Long Wu Jay S. Wunder Lucy Xia Hannah P. Yang Pan-Chyr Yang Kai Yu Krista A. Zanetti Anne Zeleniuch-Jacquotte Wei Zheng Baosen Zhou Regina G. Ziegler Luis A. Perez-Jurado Neil E. Caporaso Nathaniel Rothman Margaret Tucker Michael C. Dean Meredith Yeager Stephen J. Chanock |
| author_sort | Mitchell J. Machiela |
| collection | DOAJ |
| description | It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer risk |
| first_indexed | 2024-12-21T09:07:50Z |
| format | Article |
| id | doaj.art-ff910db139f74f1fb230ff9dacdc3391 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T09:07:50Z |
| publishDate | 2016-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-ff910db139f74f1fb230ff9dacdc33912022-12-21T19:09:18ZengNature PortfolioNature Communications2041-17232016-06-01711910.1038/ncomms11843Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosomeMitchell J. Machiela0Weiyin Zhou1Eric Karlins2Joshua N. Sampson3Neal D. Freedman4Qi Yang5Belynda Hicks6Casey Dagnall7Christopher Hautman8Kevin B. Jacobs9Christian C. Abnet10Melinda C. Aldrich11Christopher Amos12Laufey T. Amundadottir13Alan A. Arslan14Laura E. Beane-Freeman15Sonja I. Berndt16Amanda Black17William J. Blot18Cathryn H. Bock19Paige M. Bracci20Louise A. Brinton21H Bas Bueno-de-Mesquita22Laurie Burdett23Julie E. Buring24Mary A. Butler25Federico Canzian26Tania Carreón27Kari G. Chaffee28I-Shou Chang29Nilanjan Chatterjee30Chu Chen31Constance Chen32Kexin Chen33Charles C. Chung34Linda S. Cook35Marta Crous Bou36Michael Cullen37Faith G. Davis38Immaculata De Vivo39Ti Ding40Jennifer Doherty41Eric J. Duell42Caroline G. Epstein43Jin-Hu Fan44Jonine D. Figueroa45Joseph F. Fraumeni46Christine M. Friedenreich47Charles S. Fuchs48Steven Gallinger49Yu-Tang Gao50Susan M. Gapstur51Montserrat Garcia-Closas52Mia M. Gaudet53J. Michael Gaziano54Graham G. Giles55Elizabeth M. Gillanders56Edward L. Giovannucci57Lynn Goldin58Alisa M. Goldstein59Christopher A. Haiman60Goran Hallmans61Susan E. Hankinson62Curtis C. Harris63Roger Henriksson64Elizabeth A. Holly65Yun-Chul Hong66Robert N. Hoover67Chao A. Hsiung68Nan Hu69Wei Hu70David J. Hunter71Amy Hutchinson72Mazda Jenab73Christoffer Johansen74Kay-Tee Khaw75Hee Nam Kim76Yeul Hong Kim77Young Tae Kim78Alison P. Klein79Robert Klein80Woon-Puay Koh81Laurence N. Kolonel82Charles Kooperberg83Peter Kraft84Vittorio Krogh85Robert C. Kurtz86Andrea LaCroix87Qing Lan88Maria Teresa Landi89Loic Le Marchand90Donghui Li91Xiaolin Liang92Linda M. Liao93Dongxin Lin94Jianjun Liu95Jolanta Lissowska96Lingeng Lu97Anthony M. Magliocco98Nuria Malats99Keitaro Matsuo100Lorna H. McNeill101Robert R. McWilliams102Beatrice S. Melin103Lisa Mirabello104Lee Moore105Sara H. Olson106Irene Orlow107Jae Yong Park108Ana Patiño-Garcia109Beata Peplonska110Ulrike Peters111Gloria M. Petersen112Loreall Pooler113Jennifer Prescott114Ludmila Prokunina-Olsson115Mark P. Purdue116You-Lin Qiao117Preetha Rajaraman118Francisco X. Real119Elio Riboli120Harvey A. Risch121Benjamin Rodriguez-Santiago122Avima M. Ruder123Sharon A. Savage124Fredrick Schumacher125Ann G. Schwartz126Kendra L. Schwartz127Adeline Seow128Veronica Wendy Setiawan129Gianluca Severi130Hongbing Shen131Xin Sheng132Min-Ho Shin133Xiao-Ou Shu134Debra T. Silverman135Margaret R. Spitz136Victoria L. Stevens137Rachael Stolzenberg-Solomon138Daniel Stram139Ze-Zhong Tang140Philip R. Taylor141Lauren R. Teras142Geoffrey S. Tobias143David Van Den Berg144Kala Visvanathan145Sholom Wacholder146Jiu-Cun Wang147Zhaoming Wang148Nicolas Wentzensen149William Wheeler150Emily White151John K. Wiencke152Brian M. Wolpin153Maria Pik Wong154Chen Wu155Tangchun Wu156Xifeng Wu157Yi-Long Wu158Jay S. Wunder159Lucy Xia160Hannah P. Yang161Pan-Chyr Yang162Kai Yu163Krista A. Zanetti164Anne Zeleniuch-Jacquotte165Wei Zheng166Baosen Zhou167Regina G. Ziegler168Luis A. Perez-Jurado169Neil E. Caporaso170Nathaniel Rothman171Margaret Tucker172Michael C. Dean173Meredith Yeager174Stephen J. Chanock175Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, Cancer Genomics Research Laboratory, National Cancer Institute, Leidos Biomedical Research Inc.Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Department of Thoracic Surgery, Vanderbilt University School of MedicineDepartment of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer CenterDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Department of Obstetrics and Gynecology, New York University School of MedicineDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical CenterKarmanos Cancer Institute and Department of Oncology, Wayne State University School of MedicineDepartment of Epidemiology and Biostatistics, University of California San FranciscoDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Department for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Preventive Medicine, Brigham and Women’s HospitalNational Institute for Occupational Safety and Health, Centers for Disease Control and PreventionDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ)National Institute for Occupational Safety and Health, Centers for Disease Control and PreventionDepartment of Health Sciences Research, Mayo ClinicNational Institute of Cancer Research, National Health Research InstitutesDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Public Health Sciences, Fred Hutchinson Cancer Research CenterProgram in Genetic Epidemiology and Statistical Genetics, Harvard School of Public HealthDepartment of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and HospitalDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)University of New MexicoProgram in Genetic Epidemiology and Statistical Genetics, Harvard School of Public HealthDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Department of Public Health Sciences, School of Public Health, University of AlbertaProgram in Genetic Epidemiology and Statistical Genetics, Harvard School of Public HealthShanxi Cancer HospitalGeisel School of Medicine, Dartmouth CollegeUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology (ICO-IDIBELL)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Shanghai Cancer InstituteDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Department of Population Health Research, Cancer Control Alberta, Alberta Health ServicesChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical SchoolFred A Litwin Centre for Cancer Genetics, Samuel Lunenfeld Research InstituteDepartment of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotaong University School of MedicineEpidemiology Research Program, American Cancer SocietyDivision of Genetics and Epidemiology, and Breakthrough Breast Cancer Centre, Institute for Cancer ResearchEpidemiology Research Program, American Cancer SocietyDivisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolCancer Epidemiology Centre, Cancer Council Victoria & Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of MelbourneDivision of Cancer Control and Population Sciences, National Cancer InstituteChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical SchoolDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Department of Preventive Medicine, Biostatistics Division, Keck School of Medicine at the University of Southern CaliforniaDepartment of Public Health and Clinical Medicine/Nutritional Research, Umeå UniversityChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical SchoolLaboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer InstituteDepartment of Radiation Sciences, Oncology, Umeå UniversityDepartment of Epidemiology and Biostatistics, University of California San FranciscoDepartment of Preventive Medicine, Seoul National University College of MedicineDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Institute of Population Health Sciences, National Health Research InstitutesDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public HealthDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)International Agency for Research on Cancer (IARC-WHO)Oncology, Finsen CentreSchool of Clinical Medicine, University of CambridgeCenter for Creative Biomedical Scientists, Chonnam National UniversityDepartment of Internal Medicine, Division of Oncology/Hematology, College of Medicine, Korea University Anam HospitalDepartment of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University College of MedicineDepartment of Oncology, The Johns Hopkins University School of MedicineProgram in Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer CenterDuke-NUS Graduate Medical SchoolEpidemiology Program, University of Hawaii Cancer CenterDivision of Public Health Sciences, Fred Hutchinson Cancer Research CenterProgram in Genetic Epidemiology and Statistical Genetics, Harvard School of Public HealthFondazione IRCCS Istituto Nazionale dei TumoriDepartment of Medicine, Memorial Sloan-Kettering Cancer CenterDivision of Public Health Sciences, Fred Hutchinson Cancer Research CenterDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Epidemiology Program, University of Hawaii Cancer CenterDepartment of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer CenterMemorial Sloan-Kettering Cancer CenterDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Department of Etiology & Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Human Genetics, Genome Institute of SingaporeDepartment of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Cancer Center and Institute of OncologyYale School of Public HealthH. Lee Moffitt Cancer Center and Research InstituteSpanish National Cancer Research Centre (CNIO)Division of Molecular Medicine, Aichi Cancer Center Research InstituteDepartment of Health Disparities Research, Division of OVP, Cancer Prevention and Population Sciences, and Center for Community-Engaged Translational Research, Duncan Family Institute, The University of Texas MD Anderson Cancer CenterDepartment of Oncology, Mayo ClinicDepartment of Radiation Sciences, Oncology, Umeå UniversityDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Memorial Sloan-Kettering Cancer CenterMemorial Sloan-Kettering Cancer CenterLung Cancer Center, Kyungpook National University Medical CenterDepartment of Pediatrics, University Clinic of Navarra, Universidad de Navarra, IdiSNA, Navarra Institute for Health ResearchNofer Institute of Occupational MedicineDivision of Public Health Sciences, Fred Hutchinson Cancer Research CenterDepartment of Health Sciences Research, Mayo ClinicUniversity of Southern CaliforniaProgram in Genetic Epidemiology and Statistical Genetics, Harvard School of Public HealthDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Department of Epidemiology, Cancer Institute (Hospital), Chinese Academy of Medical SciencesDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Spanish National Cancer Research Centre (CNIO)Division of Epidemiology and Biostatistics, School of Public Health, Imperial College LondonYale School of Public HealthDepartament de Ciències Experimentals i de la Salut, Universitat Pompeu FabraNational Institute for Occupational Safety and Health, Centers for Disease Control and PreventionDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Department of Preventive Medicine, Biostatistics Division, Keck School of Medicine at the University of Southern CaliforniaKarmanos Cancer Institute and Department of Oncology, Wayne State University School of MedicineKarmanos Cancer Institute and Department of Family Medicine and Public Health Sciences, Wayne State University School of MedicineSaw Swee Hock School of Public Health, National University of SingaporeDepartment of Preventive Medicine, Biostatistics Division, Keck School of Medicine at the University of Southern CaliforniaCancer Epidemiology Centre, Cancer Council Victoria & Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of MelbourneJiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Nanjing Medical UniversityUniversity of Southern CaliforniaDepartment of Preventive Medicine, Chonnam National University Medical SchoolDepartment of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical CenterDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Baylor College of MedicineEpidemiology Research Program, American Cancer SocietyDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Department of Preventive Medicine, Biostatistics Division, Keck School of Medicine at the University of Southern CaliforniaShanxi Cancer HospitalDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Epidemiology Research Program, American Cancer SocietyDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Department of Preventive Medicine, Biostatistics Division, Keck School of Medicine at the University of Southern CaliforniaJohns Hopkins Bloomberg School of Public HealthDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan UniversityDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Information Management Services Inc.Division of Public Health Sciences, Fred Hutchinson Cancer Research CenterUniversity of California San FranciscoChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical SchoolDepartment of Pathology, Li Ka Shing Faculty of Medicine, The University of Hong KongDepartment of Etiology & Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeInstitute of Occupational Medicine and Ministry of Education Key Laboratory for Environment and Health, School of Public Health, Huazhong University of Science and TechnologyDepartment of Epidemiology, The University of Texas MD Anderson Cancer CenterGuangdong Lung Cancer Institute, Guangdong General Hospital & Guangdong Academy of Medical SciencesDivision of Urologic Surgery, Washington University School of MedicineUniversity of Southern CaliforniaDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Department of Internal Medicine, National Taiwan University College of MedicineDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Control and Population Sciences, National Cancer InstituteNew York University Cancer InstituteDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University Medical CenterDepartment of Epidemiology, School of Public Health, China Medical UniversityDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Departament de Ciències Experimentals i de la Salut, Universitat Pompeu FabraDivision of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)Division of Cancer Epidemiology and Genetics, National Cancer Institute (NCI), National Institutes of Health (NIH)It is unclear how often genetic mosaicism of chromosome X arises. Here, the authors examine women with cancer and cancer-free controls and show that X chromosome mosaicism occurs more frequently than on autosomes, especially on the inactive X chromosome, but is not linked to non-haematologic cancer riskhttps://doi.org/10.1038/ncomms11843 |
| spellingShingle | Mitchell J. Machiela Weiyin Zhou Eric Karlins Joshua N. Sampson Neal D. Freedman Qi Yang Belynda Hicks Casey Dagnall Christopher Hautman Kevin B. Jacobs Christian C. Abnet Melinda C. Aldrich Christopher Amos Laufey T. Amundadottir Alan A. Arslan Laura E. Beane-Freeman Sonja I. Berndt Amanda Black William J. Blot Cathryn H. Bock Paige M. Bracci Louise A. Brinton H Bas Bueno-de-Mesquita Laurie Burdett Julie E. Buring Mary A. Butler Federico Canzian Tania Carreón Kari G. Chaffee I-Shou Chang Nilanjan Chatterjee Chu Chen Constance Chen Kexin Chen Charles C. Chung Linda S. Cook Marta Crous Bou Michael Cullen Faith G. Davis Immaculata De Vivo Ti Ding Jennifer Doherty Eric J. Duell Caroline G. Epstein Jin-Hu Fan Jonine D. Figueroa Joseph F. Fraumeni Christine M. Friedenreich Charles S. Fuchs Steven Gallinger Yu-Tang Gao Susan M. Gapstur Montserrat Garcia-Closas Mia M. Gaudet J. Michael Gaziano Graham G. Giles Elizabeth M. Gillanders Edward L. Giovannucci Lynn Goldin Alisa M. Goldstein Christopher A. Haiman Goran Hallmans Susan E. Hankinson Curtis C. Harris Roger Henriksson Elizabeth A. Holly Yun-Chul Hong Robert N. Hoover Chao A. Hsiung Nan Hu Wei Hu David J. Hunter Amy Hutchinson Mazda Jenab Christoffer Johansen Kay-Tee Khaw Hee Nam Kim Yeul Hong Kim Young Tae Kim Alison P. Klein Robert Klein Woon-Puay Koh Laurence N. Kolonel Charles Kooperberg Peter Kraft Vittorio Krogh Robert C. Kurtz Andrea LaCroix Qing Lan Maria Teresa Landi Loic Le Marchand Donghui Li Xiaolin Liang Linda M. Liao Dongxin Lin Jianjun Liu Jolanta Lissowska Lingeng Lu Anthony M. Magliocco Nuria Malats Keitaro Matsuo Lorna H. McNeill Robert R. McWilliams Beatrice S. Melin Lisa Mirabello Lee Moore Sara H. Olson Irene Orlow Jae Yong Park Ana Patiño-Garcia Beata Peplonska Ulrike Peters Gloria M. Petersen Loreall Pooler Jennifer Prescott Ludmila Prokunina-Olsson Mark P. Purdue You-Lin Qiao Preetha Rajaraman Francisco X. Real Elio Riboli Harvey A. Risch Benjamin Rodriguez-Santiago Avima M. Ruder Sharon A. Savage Fredrick Schumacher Ann G. Schwartz Kendra L. Schwartz Adeline Seow Veronica Wendy Setiawan Gianluca Severi Hongbing Shen Xin Sheng Min-Ho Shin Xiao-Ou Shu Debra T. Silverman Margaret R. Spitz Victoria L. Stevens Rachael Stolzenberg-Solomon Daniel Stram Ze-Zhong Tang Philip R. Taylor Lauren R. Teras Geoffrey S. Tobias David Van Den Berg Kala Visvanathan Sholom Wacholder Jiu-Cun Wang Zhaoming Wang Nicolas Wentzensen William Wheeler Emily White John K. Wiencke Brian M. Wolpin Maria Pik Wong Chen Wu Tangchun Wu Xifeng Wu Yi-Long Wu Jay S. Wunder Lucy Xia Hannah P. Yang Pan-Chyr Yang Kai Yu Krista A. Zanetti Anne Zeleniuch-Jacquotte Wei Zheng Baosen Zhou Regina G. Ziegler Luis A. Perez-Jurado Neil E. Caporaso Nathaniel Rothman Margaret Tucker Michael C. Dean Meredith Yeager Stephen J. Chanock Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome Nature Communications |
| title | Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome |
| title_full | Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome |
| title_fullStr | Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome |
| title_full_unstemmed | Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome |
| title_short | Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome |
| title_sort | female chromosome x mosaicism is age related and preferentially affects the inactivated x chromosome |
| url | https://doi.org/10.1038/ncomms11843 |
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