Anemia and neutrophil-to-lymphocyte ratio are prognostic in p16-positive oropharyngeal carcinoma treated with concurrent chemoradiation
Objectives: We investigated the prognostic value of pre-treatment hematological parameters in patients with p16-positive oropharyngeal squamous-cell carcinoma (OPSCC). Material and methods: Neutrophil count, lymphocyte count, neutrophil-to-lymphocyte ratio (NLR), and hemoglobin concentration measure...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-06-01
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| Series: | Papillomavirus Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405852117300861 |
| _version_ | 1817977550654144512 |
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| author | Philippe Gorphe Younès Chekkoury Idrissi Yungan Tao Antoine Schernberg Dan Ou Stéphane Temam Odile Casiraghi Pierre Blanchard Haïtham Mirghani |
| author_facet | Philippe Gorphe Younès Chekkoury Idrissi Yungan Tao Antoine Schernberg Dan Ou Stéphane Temam Odile Casiraghi Pierre Blanchard Haïtham Mirghani |
| author_sort | Philippe Gorphe |
| collection | DOAJ |
| description | Objectives: We investigated the prognostic value of pre-treatment hematological parameters in patients with p16-positive oropharyngeal squamous-cell carcinoma (OPSCC). Material and methods: Neutrophil count, lymphocyte count, neutrophil-to-lymphocyte ratio (NLR), and hemoglobin concentration measurement (Hb), were collected on day one of treatment. Endpoints were overall survival (OS) and progression-free survival (PFS). All patients were planned to receive concurrent chemoradiation. Staging were reviewed according to the recent AJCC 8th edition. Results: We included 167 patients in this study. In multivariate analyses, a smoking history > 30 packyears was associated with decreased OS (p = 0.009; HR, 3.4827) and PFS (p = 0.042; HR, 2.421); Hb < 12 g/dL was associated with impaired OS (p = 0.007; HR, 6.527) and PFS (p = 0.014; HR, 4.092); an NLR > 5 before treatment was associated with decreased OS (p = 0.042; HR, 2.945). Hemoglobin concentration and the NLR were not correlated (p = 0.577), nor anemia and an NLR > 5 (p = 0.167). Patients with an NLR > 5 had a significantly higher rate of disease recurrence (30.8% vs. 8.4%, p = 0.0299, RR = 3.922, 95% CI 1.351–11.386). Discussion: We found hemoglobin level and the NLR to be independent prognostic factors in p16-positive OPSCC patients. This approach is to be considered for further clinical investigations, and its significance in treatment decision-making should be further explored. Keywords: Oropharyngeal carcinoma, P16, Papillomavirus, Smoking, Hemoglobin, Neutrophil-to-lymphocyte ratio |
| first_indexed | 2024-04-13T22:17:56Z |
| format | Article |
| id | doaj.art-ff9299aab900441d915cda1d9866c24d |
| institution | Directory Open Access Journal |
| issn | 2405-8521 |
| language | English |
| last_indexed | 2024-04-13T22:17:56Z |
| publishDate | 2018-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Papillomavirus Research |
| spelling | doaj.art-ff9299aab900441d915cda1d9866c24d2022-12-22T02:27:25ZengElsevierPapillomavirus Research2405-85212018-06-0153237Anemia and neutrophil-to-lymphocyte ratio are prognostic in p16-positive oropharyngeal carcinoma treated with concurrent chemoradiationPhilippe Gorphe0Younès Chekkoury Idrissi1Yungan Tao2Antoine Schernberg3Dan Ou4Stéphane Temam5Odile Casiraghi6Pierre Blanchard7Haïtham Mirghani8Department of Head and Neck Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France; Correspondence to: Department of Head and Neck Oncology, Gustave Roussy, 14 rue Edouard Vaillant, 94800 Villejuif, France.Department of Head and Neck Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, FranceDepartment of Radiotherapy, Gustave Roussy, Université Paris-Saclay, Villejuif, FranceDepartment of Radiotherapy, Gustave Roussy, Université Paris-Saclay, Villejuif, FranceDepartment of Radiotherapy, Gustave Roussy, Université Paris-Saclay, Villejuif, FranceDepartment of Head and Neck Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, FranceDepartment of Pathology, Gustave Roussy, Université Paris-Saclay, Villejuif, FranceDepartment of Radiotherapy, Gustave Roussy, Université Paris-Saclay, Villejuif, FranceDepartment of Head and Neck Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, FranceObjectives: We investigated the prognostic value of pre-treatment hematological parameters in patients with p16-positive oropharyngeal squamous-cell carcinoma (OPSCC). Material and methods: Neutrophil count, lymphocyte count, neutrophil-to-lymphocyte ratio (NLR), and hemoglobin concentration measurement (Hb), were collected on day one of treatment. Endpoints were overall survival (OS) and progression-free survival (PFS). All patients were planned to receive concurrent chemoradiation. Staging were reviewed according to the recent AJCC 8th edition. Results: We included 167 patients in this study. In multivariate analyses, a smoking history > 30 packyears was associated with decreased OS (p = 0.009; HR, 3.4827) and PFS (p = 0.042; HR, 2.421); Hb < 12 g/dL was associated with impaired OS (p = 0.007; HR, 6.527) and PFS (p = 0.014; HR, 4.092); an NLR > 5 before treatment was associated with decreased OS (p = 0.042; HR, 2.945). Hemoglobin concentration and the NLR were not correlated (p = 0.577), nor anemia and an NLR > 5 (p = 0.167). Patients with an NLR > 5 had a significantly higher rate of disease recurrence (30.8% vs. 8.4%, p = 0.0299, RR = 3.922, 95% CI 1.351–11.386). Discussion: We found hemoglobin level and the NLR to be independent prognostic factors in p16-positive OPSCC patients. This approach is to be considered for further clinical investigations, and its significance in treatment decision-making should be further explored. Keywords: Oropharyngeal carcinoma, P16, Papillomavirus, Smoking, Hemoglobin, Neutrophil-to-lymphocyte ratiohttp://www.sciencedirect.com/science/article/pii/S2405852117300861 |
| spellingShingle | Philippe Gorphe Younès Chekkoury Idrissi Yungan Tao Antoine Schernberg Dan Ou Stéphane Temam Odile Casiraghi Pierre Blanchard Haïtham Mirghani Anemia and neutrophil-to-lymphocyte ratio are prognostic in p16-positive oropharyngeal carcinoma treated with concurrent chemoradiation Papillomavirus Research |
| title | Anemia and neutrophil-to-lymphocyte ratio are prognostic in p16-positive oropharyngeal carcinoma treated with concurrent chemoradiation |
| title_full | Anemia and neutrophil-to-lymphocyte ratio are prognostic in p16-positive oropharyngeal carcinoma treated with concurrent chemoradiation |
| title_fullStr | Anemia and neutrophil-to-lymphocyte ratio are prognostic in p16-positive oropharyngeal carcinoma treated with concurrent chemoradiation |
| title_full_unstemmed | Anemia and neutrophil-to-lymphocyte ratio are prognostic in p16-positive oropharyngeal carcinoma treated with concurrent chemoradiation |
| title_short | Anemia and neutrophil-to-lymphocyte ratio are prognostic in p16-positive oropharyngeal carcinoma treated with concurrent chemoradiation |
| title_sort | anemia and neutrophil to lymphocyte ratio are prognostic in p16 positive oropharyngeal carcinoma treated with concurrent chemoradiation |
| url | http://www.sciencedirect.com/science/article/pii/S2405852117300861 |
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