Puerarin inhibits NHE1 activity by interfering with the p38 pathway and attenuates mitochondrial damage induced by myocardial calcium overload in heart failure rats

Puerarin inhibits NHE1 activity by interfering with the p38 pathway and attenuates mitochondrial damage induced by myocardial calcium overload in heart failure rats

Previous studies have shown that puerarin plays a key role in protecting humans and animals from cardiovascular diseases. The exact mechanism of the therapeutic effect of puerarin on various cardiovascular diseases (protective effect on cardiomyocytes) is still unclear. In the present study, we iden...

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Bibliographic Details
Main Authors: Pan Guopin, Cui Baoyue, Han Mingming, Lin Laibiao, Li Yinlan, Wang Ling, Guo Shuang, Yin Yaling, Zhan Heqin, Li Peng
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2024-01-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
puerarin
p38 pathway
NHE1
heart failure
TGF-β
proinflammatory cytokines
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2023269

Internet

https://www.sciengine.com/doi/10.3724/abbs.2023269

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