Visible-Light-Driven α-C(sp<sup>3</sup>)–H Bond Functionalization of Glycine Derivatives
The glycine motif is widely prevalent in bioactive peptides. Thus, the direct and precise modification of glycine derivatives has attracted significant attention over the past few decades. Among various protocols for the modification of glycine derivatives, the visible-light-driven direct α-C(sp<...
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MDPI AG
2023-12-01
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| Online Access: | https://www.mdpi.com/2073-4344/13/12/1502 |
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| author | Yao Tian Xiubin Bu Yuanrui Chen Luohe Wang Junnan E Jing Zeng Hao Xu Aihong Han Xiaobo Yang Zhen Zhao |
| author_facet | Yao Tian Xiubin Bu Yuanrui Chen Luohe Wang Junnan E Jing Zeng Hao Xu Aihong Han Xiaobo Yang Zhen Zhao |
| author_sort | Yao Tian |
| collection | DOAJ |
| description | The glycine motif is widely prevalent in bioactive peptides. Thus, the direct and precise modification of glycine derivatives has attracted significant attention over the past few decades. Among various protocols for the modification of glycine derivatives, the visible-light-driven direct α-C(sp<sup>3</sup>)–H bond functionalization of glycine derivatives has emerged as a powerful tool to achieve this objective, owing to its merits in atom economy, selectivity, reaction simplicity, and sustainability. This review summarizes the recent advancements in visible-light-driven direct α-C(sp<sup>3</sup>)–H bond functionalization of glycine derivatives. The contents of this review are organized based on the photocatalysts employed and the various reaction modes in the functionalization process. The mechanism, the challenges encountered, and future trends are also discussed, enabling readers to understand the current developmental status in this field. |
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| format | Article |
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| issn | 2073-4344 |
| language | English |
| last_indexed | 2024-03-08T20:55:17Z |
| publishDate | 2023-12-01 |
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| series | Catalysts |
| spelling | doaj.art-ff976fd56dd64970b37f2d73b2aea5202023-12-22T13:59:28ZengMDPI AGCatalysts2073-43442023-12-011312150210.3390/catal13121502Visible-Light-Driven α-C(sp<sup>3</sup>)–H Bond Functionalization of Glycine DerivativesYao Tian0Xiubin Bu1Yuanrui Chen2Luohe Wang3Junnan E4Jing Zeng5Hao Xu6Aihong Han7Xiaobo Yang8Zhen Zhao9Institute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, ChinaInstitute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, ChinaInstitute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, ChinaInstitute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, ChinaInstitute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, ChinaInstitute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, ChinaKey Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, ChinaInstitute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, ChinaInstitute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, ChinaInstitute of Catalysis for Energy and Environment, College of Chemistry and Chemical Engineering, Shenyang Normal University, Shenyang 110034, ChinaThe glycine motif is widely prevalent in bioactive peptides. Thus, the direct and precise modification of glycine derivatives has attracted significant attention over the past few decades. Among various protocols for the modification of glycine derivatives, the visible-light-driven direct α-C(sp<sup>3</sup>)–H bond functionalization of glycine derivatives has emerged as a powerful tool to achieve this objective, owing to its merits in atom economy, selectivity, reaction simplicity, and sustainability. This review summarizes the recent advancements in visible-light-driven direct α-C(sp<sup>3</sup>)–H bond functionalization of glycine derivatives. The contents of this review are organized based on the photocatalysts employed and the various reaction modes in the functionalization process. The mechanism, the challenges encountered, and future trends are also discussed, enabling readers to understand the current developmental status in this field.https://www.mdpi.com/2073-4344/13/12/1502visible-light-drivenα-C(sp<sup>3</sup>)–H bondC–H bond functionalizationglycine derivatives |
| spellingShingle | Yao Tian Xiubin Bu Yuanrui Chen Luohe Wang Junnan E Jing Zeng Hao Xu Aihong Han Xiaobo Yang Zhen Zhao Visible-Light-Driven α-C(sp<sup>3</sup>)–H Bond Functionalization of Glycine Derivatives Catalysts visible-light-driven α-C(sp<sup>3</sup>)–H bond C–H bond functionalization glycine derivatives |
| title | Visible-Light-Driven α-C(sp<sup>3</sup>)–H Bond Functionalization of Glycine Derivatives |
| title_full | Visible-Light-Driven α-C(sp<sup>3</sup>)–H Bond Functionalization of Glycine Derivatives |
| title_fullStr | Visible-Light-Driven α-C(sp<sup>3</sup>)–H Bond Functionalization of Glycine Derivatives |
| title_full_unstemmed | Visible-Light-Driven α-C(sp<sup>3</sup>)–H Bond Functionalization of Glycine Derivatives |
| title_short | Visible-Light-Driven α-C(sp<sup>3</sup>)–H Bond Functionalization of Glycine Derivatives |
| title_sort | visible light driven α c sp sup 3 sup h bond functionalization of glycine derivatives |
| topic | visible-light-driven α-C(sp<sup>3</sup>)–H bond C–H bond functionalization glycine derivatives |
| url | https://www.mdpi.com/2073-4344/13/12/1502 |
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