Prognostic Significance of Systemic Arterial Stiffness Evaluated by Cardio-Ankle Vascular Index in Patients with Idiopathic Pulmonary Hypertension
Ganna D Radchenko, Yuriy M Sirenko Department of Symptomatic Hypertension, “National Scientific Center “The M.D. Strazhesko Institute of Cardiology”” of National Academy of Medical Science, Kyiv, UkraineCorrespondence: Ganna D RadchenkoDepartment of Symptomati...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2021-03-01
|
| Series: | Vascular Health and Risk Management |
| Subjects: | |
| Online Access: | https://www.dovepress.com/prognostic-significance-of-systemic-arterial-stiffness-evaluated-by-ca-peer-reviewed-article-VHRM |
| _version_ | 1818914843353153536 |
|---|---|
| author | Radchenko GD Sirenko YM |
| author_facet | Radchenko GD Sirenko YM |
| author_sort | Radchenko GD |
| collection | DOAJ |
| description | Ganna D Radchenko, Yuriy M Sirenko Department of Symptomatic Hypertension, “National Scientific Center “The M.D. Strazhesko Institute of Cardiology”” of National Academy of Medical Science, Kyiv, UkraineCorrespondence: Ganna D RadchenkoDepartment of Symptomatic Hypertension, “National Scientific Center “The M.D. Strazhesko Institute of Cardiology”” of National Academy of Medical Science, 5, Narodnogo Opolchenia Str, Kyiv, 03680, UkraineTel +380 667128405Email rganna@bigmir.netBackground: In a previous study, the cardio-ankle vascular index (CAVI) was increased significantly in idiopathic pulmonary arterial hypertension (IPAH) patients compared to the healthy group and did not much differ from one in systemic hypertensives. In this study the relations between survival and CAVI was evaluated in patients with IPAH.Patients and Methods: We included 89 patients with new-diagnosed IPAH without concomitant diseases. Standard examinations, including right heart catheterization (RHC) and systemic arterial stiffness evaluation, were performed. All patients were divided according to CAVI value: the group with CAVI ≥ 8 (n = 18) and the group with CAVI < 8 (n = 71). The mean follow-up was 33.8 ± 23.7 months. Kaplan–Meier and Cox regression analysis were performed for the evaluation of our cohort survival and the predictors of death.Results: The group with CAVI≥ 8 was older and more severe compared to the group with CAVI< 8. Patients with CAVI≥ 8 had significantly reduced end-diastolic (73.79± 18.94 vs 87.35± 16.69 mL, P< 0.009) and end-systolic (25.71± 9.56 vs 33.55± 10.33 mL, P< 0.01) volumes of the left ventricle, the higher right ventricle thickness (0.77± 0.12 vs 0.62± 0.20 mm, P < 0.006), and the lower TAPSE (13.38± 2.15 vs 15.98± 4.4 mm, P< 0.018). RHC data did not differ significantly between groups, except the higher level of the right atrial pressure in patients with CAVI≥ 8– 11.38± 7.1 vs 8.76± 4.7 mmHg, P< 0.08. The estimated overall survival rate was 61.2%. The CAVI≥ 8 increased the risk of mortality 2.34 times (CI 1.04– 5.28, P = 0.041). The estimated Kaplan–Meier survival in the patients with CAVI ≥ 8 was only 46.7 ± 7.18% compared to patients with CAVI < 8 - 65.6 ± 4.2%, P = 0.035. At multifactorial regression analysis, the CAVI reduced but saved its relevance as death predictor - OR = 1.13, CI 1.001– 1.871.Summary: We suggested the CAVI could be a new independent predictor of death in the IPAH population and could be used to better risk stratify this patient population if CAVI is validated as a marker in a larger multicenter trial.Keywords: idiopathic pulmonary arterial hypertension, systemic arterial stiffness, pulse wave velocity, cardio-ankle vascular index, survival |
| first_indexed | 2024-12-19T23:52:49Z |
| format | Article |
| id | doaj.art-ff97a7156f454d7094b550ed7a927798 |
| institution | Directory Open Access Journal |
| issn | 1178-2048 |
| language | English |
| last_indexed | 2024-12-19T23:52:49Z |
| publishDate | 2021-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-ff97a7156f454d7094b550ed7a9277982022-12-21T20:01:05ZengDove Medical PressVascular Health and Risk Management1178-20482021-03-01Volume 17779362876Prognostic Significance of Systemic Arterial Stiffness Evaluated by Cardio-Ankle Vascular Index in Patients with Idiopathic Pulmonary HypertensionRadchenko GDSirenko YMGanna D Radchenko, Yuriy M Sirenko Department of Symptomatic Hypertension, “National Scientific Center “The M.D. Strazhesko Institute of Cardiology”” of National Academy of Medical Science, Kyiv, UkraineCorrespondence: Ganna D RadchenkoDepartment of Symptomatic Hypertension, “National Scientific Center “The M.D. Strazhesko Institute of Cardiology”” of National Academy of Medical Science, 5, Narodnogo Opolchenia Str, Kyiv, 03680, UkraineTel +380 667128405Email rganna@bigmir.netBackground: In a previous study, the cardio-ankle vascular index (CAVI) was increased significantly in idiopathic pulmonary arterial hypertension (IPAH) patients compared to the healthy group and did not much differ from one in systemic hypertensives. In this study the relations between survival and CAVI was evaluated in patients with IPAH.Patients and Methods: We included 89 patients with new-diagnosed IPAH without concomitant diseases. Standard examinations, including right heart catheterization (RHC) and systemic arterial stiffness evaluation, were performed. All patients were divided according to CAVI value: the group with CAVI ≥ 8 (n = 18) and the group with CAVI < 8 (n = 71). The mean follow-up was 33.8 ± 23.7 months. Kaplan–Meier and Cox regression analysis were performed for the evaluation of our cohort survival and the predictors of death.Results: The group with CAVI≥ 8 was older and more severe compared to the group with CAVI< 8. Patients with CAVI≥ 8 had significantly reduced end-diastolic (73.79± 18.94 vs 87.35± 16.69 mL, P< 0.009) and end-systolic (25.71± 9.56 vs 33.55± 10.33 mL, P< 0.01) volumes of the left ventricle, the higher right ventricle thickness (0.77± 0.12 vs 0.62± 0.20 mm, P < 0.006), and the lower TAPSE (13.38± 2.15 vs 15.98± 4.4 mm, P< 0.018). RHC data did not differ significantly between groups, except the higher level of the right atrial pressure in patients with CAVI≥ 8– 11.38± 7.1 vs 8.76± 4.7 mmHg, P< 0.08. The estimated overall survival rate was 61.2%. The CAVI≥ 8 increased the risk of mortality 2.34 times (CI 1.04– 5.28, P = 0.041). The estimated Kaplan–Meier survival in the patients with CAVI ≥ 8 was only 46.7 ± 7.18% compared to patients with CAVI < 8 - 65.6 ± 4.2%, P = 0.035. At multifactorial regression analysis, the CAVI reduced but saved its relevance as death predictor - OR = 1.13, CI 1.001– 1.871.Summary: We suggested the CAVI could be a new independent predictor of death in the IPAH population and could be used to better risk stratify this patient population if CAVI is validated as a marker in a larger multicenter trial.Keywords: idiopathic pulmonary arterial hypertension, systemic arterial stiffness, pulse wave velocity, cardio-ankle vascular index, survivalhttps://www.dovepress.com/prognostic-significance-of-systemic-arterial-stiffness-evaluated-by-ca-peer-reviewed-article-VHRMidiopathic pulmonary arterial hypertensionsystemic arterial stiffnesspulse wave velocitycardio-ankle vascular indexsurvival |
| spellingShingle | Radchenko GD Sirenko YM Prognostic Significance of Systemic Arterial Stiffness Evaluated by Cardio-Ankle Vascular Index in Patients with Idiopathic Pulmonary Hypertension Vascular Health and Risk Management idiopathic pulmonary arterial hypertension systemic arterial stiffness pulse wave velocity cardio-ankle vascular index survival |
| title | Prognostic Significance of Systemic Arterial Stiffness Evaluated by Cardio-Ankle Vascular Index in Patients with Idiopathic Pulmonary Hypertension |
| title_full | Prognostic Significance of Systemic Arterial Stiffness Evaluated by Cardio-Ankle Vascular Index in Patients with Idiopathic Pulmonary Hypertension |
| title_fullStr | Prognostic Significance of Systemic Arterial Stiffness Evaluated by Cardio-Ankle Vascular Index in Patients with Idiopathic Pulmonary Hypertension |
| title_full_unstemmed | Prognostic Significance of Systemic Arterial Stiffness Evaluated by Cardio-Ankle Vascular Index in Patients with Idiopathic Pulmonary Hypertension |
| title_short | Prognostic Significance of Systemic Arterial Stiffness Evaluated by Cardio-Ankle Vascular Index in Patients with Idiopathic Pulmonary Hypertension |
| title_sort | prognostic significance of systemic arterial stiffness evaluated by cardio ankle vascular index in patients with idiopathic pulmonary hypertension |
| topic | idiopathic pulmonary arterial hypertension systemic arterial stiffness pulse wave velocity cardio-ankle vascular index survival |
| url | https://www.dovepress.com/prognostic-significance-of-systemic-arterial-stiffness-evaluated-by-ca-peer-reviewed-article-VHRM |
| work_keys_str_mv | AT radchenkogd prognosticsignificanceofsystemicarterialstiffnessevaluatedbycardioanklevascularindexinpatientswithidiopathicpulmonaryhypertension AT sirenkoym prognosticsignificanceofsystemicarterialstiffnessevaluatedbycardioanklevascularindexinpatientswithidiopathicpulmonaryhypertension |