Increased Expression of TGFβR2 Is Associated with the Clinical Outcome of Non-Small Cell Lung Cancer Patients Treated with Chemotherapy.
To investigate the prognostic significance of TGFβR2 expression and chemotherapy in Chinese non-small cell lung cancer (NSCLC) patients, TGFβR2 expression NSCLC was analyzed in silico using the Oncomine database, and subsequently analyzed with quantitative RT-PCR in 308 NSCLC biopsies, 42 of which w...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4529313?pdf=render |
| _version_ | 1818433189015715840 |
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| author | Yang Han Chengyou Jia Xianling Cong Fei Yu Haidong Cai Suyun Fang Li Cai Huiqiong Yang Yu Sun Dan Li Jin Liu Ruting Xie Xueyu Yuan Xiaoming Zhong Ming Li Qing Wei Zhongwei Lv Da Fu Yushui Ma |
| author_facet | Yang Han Chengyou Jia Xianling Cong Fei Yu Haidong Cai Suyun Fang Li Cai Huiqiong Yang Yu Sun Dan Li Jin Liu Ruting Xie Xueyu Yuan Xiaoming Zhong Ming Li Qing Wei Zhongwei Lv Da Fu Yushui Ma |
| author_sort | Yang Han |
| collection | DOAJ |
| description | To investigate the prognostic significance of TGFβR2 expression and chemotherapy in Chinese non-small cell lung cancer (NSCLC) patients, TGFβR2 expression NSCLC was analyzed in silico using the Oncomine database, and subsequently analyzed with quantitative RT-PCR in 308 NSCLC biopsies, 42 of which were paired with adjacent non-neoplastic tissues. Our results show that TGFβR2 expression was also increased in NSCLC biopsies relative to normal tissue samples and correlated with poor prognosis. TGFβR2 expression was also significantly correlated with other clinical parameters such as tumor differentiation, invasion of lung membrane, and chemotherapy. Moreover, overall survival (OS) and disease free survival (DFS) was increased in patients with low TGFβR2 expressing NSCLC and who had undergone chemotherapy. Thus, high expression of TGFβR2 is a significant risk factor for decreased OS and DFS in NSCLC patients. Thus, TGFβR2 is a potential prognostic tumor biomarker for chemotherapy. |
| first_indexed | 2024-12-14T16:17:08Z |
| format | Article |
| id | doaj.art-ff991fa2e9ee40f18ca3a105adfb8146 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T16:17:08Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ff991fa2e9ee40f18ca3a105adfb81462022-12-21T22:54:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01108e013468210.1371/journal.pone.0134682Increased Expression of TGFβR2 Is Associated with the Clinical Outcome of Non-Small Cell Lung Cancer Patients Treated with Chemotherapy.Yang HanChengyou JiaXianling CongFei YuHaidong CaiSuyun FangLi CaiHuiqiong YangYu SunDan LiJin LiuRuting XieXueyu YuanXiaoming ZhongMing LiQing WeiZhongwei LvDa FuYushui MaTo investigate the prognostic significance of TGFβR2 expression and chemotherapy in Chinese non-small cell lung cancer (NSCLC) patients, TGFβR2 expression NSCLC was analyzed in silico using the Oncomine database, and subsequently analyzed with quantitative RT-PCR in 308 NSCLC biopsies, 42 of which were paired with adjacent non-neoplastic tissues. Our results show that TGFβR2 expression was also increased in NSCLC biopsies relative to normal tissue samples and correlated with poor prognosis. TGFβR2 expression was also significantly correlated with other clinical parameters such as tumor differentiation, invasion of lung membrane, and chemotherapy. Moreover, overall survival (OS) and disease free survival (DFS) was increased in patients with low TGFβR2 expressing NSCLC and who had undergone chemotherapy. Thus, high expression of TGFβR2 is a significant risk factor for decreased OS and DFS in NSCLC patients. Thus, TGFβR2 is a potential prognostic tumor biomarker for chemotherapy.http://europepmc.org/articles/PMC4529313?pdf=render |
| spellingShingle | Yang Han Chengyou Jia Xianling Cong Fei Yu Haidong Cai Suyun Fang Li Cai Huiqiong Yang Yu Sun Dan Li Jin Liu Ruting Xie Xueyu Yuan Xiaoming Zhong Ming Li Qing Wei Zhongwei Lv Da Fu Yushui Ma Increased Expression of TGFβR2 Is Associated with the Clinical Outcome of Non-Small Cell Lung Cancer Patients Treated with Chemotherapy. PLoS ONE |
| title | Increased Expression of TGFβR2 Is Associated with the Clinical Outcome of Non-Small Cell Lung Cancer Patients Treated with Chemotherapy. |
| title_full | Increased Expression of TGFβR2 Is Associated with the Clinical Outcome of Non-Small Cell Lung Cancer Patients Treated with Chemotherapy. |
| title_fullStr | Increased Expression of TGFβR2 Is Associated with the Clinical Outcome of Non-Small Cell Lung Cancer Patients Treated with Chemotherapy. |
| title_full_unstemmed | Increased Expression of TGFβR2 Is Associated with the Clinical Outcome of Non-Small Cell Lung Cancer Patients Treated with Chemotherapy. |
| title_short | Increased Expression of TGFβR2 Is Associated with the Clinical Outcome of Non-Small Cell Lung Cancer Patients Treated with Chemotherapy. |
| title_sort | increased expression of tgfβr2 is associated with the clinical outcome of non small cell lung cancer patients treated with chemotherapy |
| url | http://europepmc.org/articles/PMC4529313?pdf=render |
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