Extracellular overproduction of E7 oncoprotein of Iranian human papillomavirus type 16 by genetically engineered Lactococcus lactis

Extracellular overproduction of E7 oncoprotein of Iranian human papillomavirus type 16 by genetically engineered Lactococcus lactis

Abstract Background We aimed at constructing Lactococcus lactis strains expressing HPV-16 recombinant E7 (rE7) oncoprotein and examining its overproduction ability followed by optimizing batch and fed-batch fermentations. Thereafter, in order to assess the immunogenicity of recombinant L. lactis cel...

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Bibliographic Details
Main Authors: Amir Hossein Mohseni, Sedigheh Taghinezhad-S, Hossein Keyvani, Vadood Razavilar
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Biotechnology
Subjects:
Lactococcus lactis
HPV-16
Protein secretion
Optimization
Batch and fed-batch fermentation
Online Access:http://link.springer.com/article/10.1186/s12896-019-0499-5

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