Are MRI-defined fat infiltrations in the multifidus muscles associated with low back pain?
<p>Abstract</p> <p>Background</p> <p>Because training of the lumbar muscles is a commonly recommended intervention in low back pain (LBP), it is important to clarify whether lumbar muscle atrophy is related to LBP. Fat infiltration seems to be a late stage of muscular d...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2007-01-01
|
| Series: | BMC Medicine |
| Online Access: | http://www.biomedcentral.com/1741-7015/5/2 |
| _version_ | 1829469868434391040 |
|---|---|
| author | Korsholm Lars Sorensen Joan Bendix Tom Kjaer Per Leboeuf-Yde Charlotte |
| author_facet | Korsholm Lars Sorensen Joan Bendix Tom Kjaer Per Leboeuf-Yde Charlotte |
| author_sort | Korsholm Lars |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Because training of the lumbar muscles is a commonly recommended intervention in low back pain (LBP), it is important to clarify whether lumbar muscle atrophy is related to LBP. Fat infiltration seems to be a late stage of muscular degeneration, and can be measured in a non-invasive manner using magnetic resonance imaging. The purpose of this study was to investigate if fat infiltration in the lumbar multifidus muscles (LMM) is associated with LBP in adults and adolescents.</p> <p>Methods</p> <p>In total, 412 adults (40-year-olds) and 442 adolescents (13-year-olds) from the general Danish population participated in this cross-sectional cohort study. People with LBP were identified through questionnaires. Using MRI, fat infiltration of the LMM was visually graded as none, slight or severe. Odds ratios were calculated for both age groups, taking into account sex, body composition and leisure time physical activity for both groups, and physical workload (in adults only) or daily bicycling (in adolescents only).</p> <p>Results</p> <p>Fat infiltration was noted in 81% of the adults but only 14% of the adolescents. In the adults, severe fat infiltration was strongly associated with ever having had LBP (OR 9.2; 95% CI 2.0–43.2), and with having LBP in the past year (OR 4.1; 1.5–11.2), but there was no such association in adolescents. None of the investigated moderating factors had an obvious effect on the OR in the adults.</p> <p>Conclusion</p> <p>Fat infiltration in the LMM is strongly associated with LBP in adults only. However, it will be necessary to quantify these measurements objectively and to investigate the direction of this link longitudinally in order to determine if the abnormal muscle is the cause of LBP or <it>vice versa</it>.</p> |
| first_indexed | 2024-12-14T01:37:59Z |
| format | Article |
| id | doaj.art-ff9c900cd1934487b2a27e695ab605bf |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-12-14T01:37:59Z |
| publishDate | 2007-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-ff9c900cd1934487b2a27e695ab605bf2022-12-21T23:21:50ZengBMCBMC Medicine1741-70152007-01-0151210.1186/1741-7015-5-2Are MRI-defined fat infiltrations in the multifidus muscles associated with low back pain?Korsholm LarsSorensen JoanBendix TomKjaer PerLeboeuf-Yde Charlotte<p>Abstract</p> <p>Background</p> <p>Because training of the lumbar muscles is a commonly recommended intervention in low back pain (LBP), it is important to clarify whether lumbar muscle atrophy is related to LBP. Fat infiltration seems to be a late stage of muscular degeneration, and can be measured in a non-invasive manner using magnetic resonance imaging. The purpose of this study was to investigate if fat infiltration in the lumbar multifidus muscles (LMM) is associated with LBP in adults and adolescents.</p> <p>Methods</p> <p>In total, 412 adults (40-year-olds) and 442 adolescents (13-year-olds) from the general Danish population participated in this cross-sectional cohort study. People with LBP were identified through questionnaires. Using MRI, fat infiltration of the LMM was visually graded as none, slight or severe. Odds ratios were calculated for both age groups, taking into account sex, body composition and leisure time physical activity for both groups, and physical workload (in adults only) or daily bicycling (in adolescents only).</p> <p>Results</p> <p>Fat infiltration was noted in 81% of the adults but only 14% of the adolescents. In the adults, severe fat infiltration was strongly associated with ever having had LBP (OR 9.2; 95% CI 2.0–43.2), and with having LBP in the past year (OR 4.1; 1.5–11.2), but there was no such association in adolescents. None of the investigated moderating factors had an obvious effect on the OR in the adults.</p> <p>Conclusion</p> <p>Fat infiltration in the LMM is strongly associated with LBP in adults only. However, it will be necessary to quantify these measurements objectively and to investigate the direction of this link longitudinally in order to determine if the abnormal muscle is the cause of LBP or <it>vice versa</it>.</p>http://www.biomedcentral.com/1741-7015/5/2 |
| spellingShingle | Korsholm Lars Sorensen Joan Bendix Tom Kjaer Per Leboeuf-Yde Charlotte Are MRI-defined fat infiltrations in the multifidus muscles associated with low back pain? BMC Medicine |
| title | Are MRI-defined fat infiltrations in the multifidus muscles associated with low back pain? |
| title_full | Are MRI-defined fat infiltrations in the multifidus muscles associated with low back pain? |
| title_fullStr | Are MRI-defined fat infiltrations in the multifidus muscles associated with low back pain? |
| title_full_unstemmed | Are MRI-defined fat infiltrations in the multifidus muscles associated with low back pain? |
| title_short | Are MRI-defined fat infiltrations in the multifidus muscles associated with low back pain? |
| title_sort | are mri defined fat infiltrations in the multifidus muscles associated with low back pain |
| url | http://www.biomedcentral.com/1741-7015/5/2 |
| work_keys_str_mv | AT korsholmlars aremridefinedfatinfiltrationsinthemultifidusmusclesassociatedwithlowbackpain AT sorensenjoan aremridefinedfatinfiltrationsinthemultifidusmusclesassociatedwithlowbackpain AT bendixtom aremridefinedfatinfiltrationsinthemultifidusmusclesassociatedwithlowbackpain AT kjaerper aremridefinedfatinfiltrationsinthemultifidusmusclesassociatedwithlowbackpain AT leboeufydecharlotte aremridefinedfatinfiltrationsinthemultifidusmusclesassociatedwithlowbackpain |