Inflammation-Related Molecules at the Maternal–Fetal Interface during Pregnancy and in Pathologically Altered Endometrium
The blastocyst expresses paternally derived alloantigens and induces inflammation during implantation. However, it is necessary for the onset of pregnancy. An abnormal response might result in a pathological course of pregnancy or pregnancy failure. On the other hand, a state of maternal immune tole...
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MDPI AG
2022-08-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/44/9/260 |
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| author | Wlodzimierz Sieg Jolanta Kiewisz Amira Podolak Grzegorz Jakiel Izabela Woclawek-Potocka Jakub Lukaszuk Krzysztof Lukaszuk |
| author_facet | Wlodzimierz Sieg Jolanta Kiewisz Amira Podolak Grzegorz Jakiel Izabela Woclawek-Potocka Jakub Lukaszuk Krzysztof Lukaszuk |
| author_sort | Wlodzimierz Sieg |
| collection | DOAJ |
| description | The blastocyst expresses paternally derived alloantigens and induces inflammation during implantation. However, it is necessary for the onset of pregnancy. An abnormal response might result in a pathological course of pregnancy or pregnancy failure. On the other hand, a state of maternal immune tolerance is necessary to ensure the normal development of pregnancy by suppressing inflammatory processes. This article discusses recognized mechanisms and the significance of inflammatory processes for embryo implantation and pregnancy establishment. We would also like to present disorders involving excessive inflammatory response and their influence on events occurring during embryo implantation. The chain of correlation between the processes responsible for embryo implantation and the subsequent physiological course of pregnancy is complicated. Many of those interrelationships are still yet to be discovered. Undoubtedly, their recognition will give hope to infertile couples for the emergence of new treatments that will increase the chance of giving birth to a healthy child. |
| first_indexed | 2024-03-10T00:23:21Z |
| format | Article |
| id | doaj.art-ff9c98541b0a4370b59257d18b9aeee6 |
| institution | Directory Open Access Journal |
| issn | 1467-3037 1467-3045 |
| language | English |
| last_indexed | 2024-03-10T00:23:21Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj.art-ff9c98541b0a4370b59257d18b9aeee62023-11-23T15:38:50ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452022-08-014493792380810.3390/cimb44090260Inflammation-Related Molecules at the Maternal–Fetal Interface during Pregnancy and in Pathologically Altered EndometriumWlodzimierz Sieg0Jolanta Kiewisz1Amira Podolak2Grzegorz Jakiel3Izabela Woclawek-Potocka4Jakub Lukaszuk5Krzysztof Lukaszuk6Invicta Research and Development Center, 81-740 Sopot, PolandDepartment of Human Histology and Embryology, Medical Faculty, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-561 Olsztyn, PolandDepartment of Obstetrics and Gynecology Nursing, Medical University of Gdansk, 80-210 Gdansk, PolandInvicta Research and Development Center, 81-740 Sopot, PolandDepartment of Gamete and Embryo Biology, Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, 10-748 Olsztyn, PolandInvicta Research and Development Center, 81-740 Sopot, PolandInvicta Research and Development Center, 81-740 Sopot, PolandThe blastocyst expresses paternally derived alloantigens and induces inflammation during implantation. However, it is necessary for the onset of pregnancy. An abnormal response might result in a pathological course of pregnancy or pregnancy failure. On the other hand, a state of maternal immune tolerance is necessary to ensure the normal development of pregnancy by suppressing inflammatory processes. This article discusses recognized mechanisms and the significance of inflammatory processes for embryo implantation and pregnancy establishment. We would also like to present disorders involving excessive inflammatory response and their influence on events occurring during embryo implantation. The chain of correlation between the processes responsible for embryo implantation and the subsequent physiological course of pregnancy is complicated. Many of those interrelationships are still yet to be discovered. Undoubtedly, their recognition will give hope to infertile couples for the emergence of new treatments that will increase the chance of giving birth to a healthy child.https://www.mdpi.com/1467-3045/44/9/260implantationinflammatory processesinflammationendometriumreproductive immunologypregnancy |
| spellingShingle | Wlodzimierz Sieg Jolanta Kiewisz Amira Podolak Grzegorz Jakiel Izabela Woclawek-Potocka Jakub Lukaszuk Krzysztof Lukaszuk Inflammation-Related Molecules at the Maternal–Fetal Interface during Pregnancy and in Pathologically Altered Endometrium Current Issues in Molecular Biology implantation inflammatory processes inflammation endometrium reproductive immunology pregnancy |
| title | Inflammation-Related Molecules at the Maternal–Fetal Interface during Pregnancy and in Pathologically Altered Endometrium |
| title_full | Inflammation-Related Molecules at the Maternal–Fetal Interface during Pregnancy and in Pathologically Altered Endometrium |
| title_fullStr | Inflammation-Related Molecules at the Maternal–Fetal Interface during Pregnancy and in Pathologically Altered Endometrium |
| title_full_unstemmed | Inflammation-Related Molecules at the Maternal–Fetal Interface during Pregnancy and in Pathologically Altered Endometrium |
| title_short | Inflammation-Related Molecules at the Maternal–Fetal Interface during Pregnancy and in Pathologically Altered Endometrium |
| title_sort | inflammation related molecules at the maternal fetal interface during pregnancy and in pathologically altered endometrium |
| topic | implantation inflammatory processes inflammation endometrium reproductive immunology pregnancy |
| url | https://www.mdpi.com/1467-3045/44/9/260 |
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