Dynamic Crosslinked Injectable Mussel-Inspired Hydrogels with Adhesive, Self-Healing, and Biodegradation Properties
The non-invasive tissue adhesives with strong tissue adhesion and good biocompatibility are ideal for replacing traditional wound treatment methods such as sutures and needles. The self-healing hydrogels based on dynamic reversible crosslinking can recover their structure and function after damage,...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Polymers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4360/15/8/1876 |
| _version_ | 1797603777198424064 |
|---|---|
| author | Ruixiao Wang Liqun Liu Xiang He Zongmei Xia Zhenjie Zhao Zhenhao Xi Juan Yu Jie Wang |
| author_facet | Ruixiao Wang Liqun Liu Xiang He Zongmei Xia Zhenjie Zhao Zhenhao Xi Juan Yu Jie Wang |
| author_sort | Ruixiao Wang |
| collection | DOAJ |
| description | The non-invasive tissue adhesives with strong tissue adhesion and good biocompatibility are ideal for replacing traditional wound treatment methods such as sutures and needles. The self-healing hydrogels based on dynamic reversible crosslinking can recover their structure and function after damage, which is suitable for the application scenario of tissue adhesives. Herein, inspired by mussel adhesive proteins, we propose a facile strategy to achieve an injectable hydrogel (DACS hydrogel) by grafting dopamine (DOPA) onto hyaluronic acid (HA) and mixing it with carboxymethyl chitosan (CMCS) solution. The gelation time and rheological and swelling properties of the hydrogel can be controlled conveniently by adjusting the substitution degree of the catechol group and the concentration of raw materials. More importantly, the hydrogel exhibited rapid and highly efficient self-healing ability and excellent biodegradation and biocompatibility in vitro. Meanwhile, the hydrogel exhibited ~4-fold enhanced wet tissue adhesion strength (21.41 kPa) over the commercial fibrin glue. This kind of HA-based mussel biomimetic self-healing hydrogel is expected to be used as a multifunctional tissue adhesive material. |
| first_indexed | 2024-03-11T04:36:54Z |
| format | Article |
| id | doaj.art-ff9d30cb0ac84256b4e131260570e827 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-11T04:36:54Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-ff9d30cb0ac84256b4e131260570e8272023-11-17T21:01:51ZengMDPI AGPolymers2073-43602023-04-01158187610.3390/polym15081876Dynamic Crosslinked Injectable Mussel-Inspired Hydrogels with Adhesive, Self-Healing, and Biodegradation PropertiesRuixiao Wang0Liqun Liu1Xiang He2Zongmei Xia3Zhenjie Zhao4Zhenhao Xi5Juan Yu6Jie Wang7State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, ChinaState Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, ChinaState Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, ChinaState Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, ChinaState Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, ChinaState Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, ChinaState Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, ChinaState Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, ChinaThe non-invasive tissue adhesives with strong tissue adhesion and good biocompatibility are ideal for replacing traditional wound treatment methods such as sutures and needles. The self-healing hydrogels based on dynamic reversible crosslinking can recover their structure and function after damage, which is suitable for the application scenario of tissue adhesives. Herein, inspired by mussel adhesive proteins, we propose a facile strategy to achieve an injectable hydrogel (DACS hydrogel) by grafting dopamine (DOPA) onto hyaluronic acid (HA) and mixing it with carboxymethyl chitosan (CMCS) solution. The gelation time and rheological and swelling properties of the hydrogel can be controlled conveniently by adjusting the substitution degree of the catechol group and the concentration of raw materials. More importantly, the hydrogel exhibited rapid and highly efficient self-healing ability and excellent biodegradation and biocompatibility in vitro. Meanwhile, the hydrogel exhibited ~4-fold enhanced wet tissue adhesion strength (21.41 kPa) over the commercial fibrin glue. This kind of HA-based mussel biomimetic self-healing hydrogel is expected to be used as a multifunctional tissue adhesive material.https://www.mdpi.com/2073-4360/15/8/1876tissue adhesivein situ hydrogelhyaluronic acidcarboxymethyl chitosan |
| spellingShingle | Ruixiao Wang Liqun Liu Xiang He Zongmei Xia Zhenjie Zhao Zhenhao Xi Juan Yu Jie Wang Dynamic Crosslinked Injectable Mussel-Inspired Hydrogels with Adhesive, Self-Healing, and Biodegradation Properties Polymers tissue adhesive in situ hydrogel hyaluronic acid carboxymethyl chitosan |
| title | Dynamic Crosslinked Injectable Mussel-Inspired Hydrogels with Adhesive, Self-Healing, and Biodegradation Properties |
| title_full | Dynamic Crosslinked Injectable Mussel-Inspired Hydrogels with Adhesive, Self-Healing, and Biodegradation Properties |
| title_fullStr | Dynamic Crosslinked Injectable Mussel-Inspired Hydrogels with Adhesive, Self-Healing, and Biodegradation Properties |
| title_full_unstemmed | Dynamic Crosslinked Injectable Mussel-Inspired Hydrogels with Adhesive, Self-Healing, and Biodegradation Properties |
| title_short | Dynamic Crosslinked Injectable Mussel-Inspired Hydrogels with Adhesive, Self-Healing, and Biodegradation Properties |
| title_sort | dynamic crosslinked injectable mussel inspired hydrogels with adhesive self healing and biodegradation properties |
| topic | tissue adhesive in situ hydrogel hyaluronic acid carboxymethyl chitosan |
| url | https://www.mdpi.com/2073-4360/15/8/1876 |
| work_keys_str_mv | AT ruixiaowang dynamiccrosslinkedinjectablemusselinspiredhydrogelswithadhesiveselfhealingandbiodegradationproperties AT liqunliu dynamiccrosslinkedinjectablemusselinspiredhydrogelswithadhesiveselfhealingandbiodegradationproperties AT xianghe dynamiccrosslinkedinjectablemusselinspiredhydrogelswithadhesiveselfhealingandbiodegradationproperties AT zongmeixia dynamiccrosslinkedinjectablemusselinspiredhydrogelswithadhesiveselfhealingandbiodegradationproperties AT zhenjiezhao dynamiccrosslinkedinjectablemusselinspiredhydrogelswithadhesiveselfhealingandbiodegradationproperties AT zhenhaoxi dynamiccrosslinkedinjectablemusselinspiredhydrogelswithadhesiveselfhealingandbiodegradationproperties AT juanyu dynamiccrosslinkedinjectablemusselinspiredhydrogelswithadhesiveselfhealingandbiodegradationproperties AT jiewang dynamiccrosslinkedinjectablemusselinspiredhydrogelswithadhesiveselfhealingandbiodegradationproperties |