Intensity of statin therapy and renal outcome in chronic kidney disease: Results from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease
Background : : Higher statin intensity is associated with a lower risk of mortality in patients with cardiovascular disease. However, little is known about the relationship between statin intensity and chronic kidney disease (CKD) progression. Methods : : We studied whether statin intensity affects...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Korean Society of Nephrology
2020-03-01
|
| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | https://doi.org/10.23876/j.krcp.20.007 |
| _version_ | 1818932546216394752 |
|---|---|
| author | Jong Hyun Jhee Young Su Joo Jung Tak Park Tae-Hyun Yoo Sue Kyung Park Ji Yong Jung Soo Wan Kim Yun Kyu Oh Kook-Hwan Oh Shin-Wook Kang Kyu Hun Choi Curie Ahn Seung Hyeok Han |
| author_facet | Jong Hyun Jhee Young Su Joo Jung Tak Park Tae-Hyun Yoo Sue Kyung Park Ji Yong Jung Soo Wan Kim Yun Kyu Oh Kook-Hwan Oh Shin-Wook Kang Kyu Hun Choi Curie Ahn Seung Hyeok Han |
| author_sort | Jong Hyun Jhee |
| collection | DOAJ |
| description | Background : : Higher statin intensity is associated with a lower risk of mortality in patients with cardiovascular disease. However, little is known about the relationship between statin intensity and chronic kidney disease (CKD) progression.
Methods : : We studied whether statin intensity affects kidney function decline in 1,073 patients from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease. The participants were classified based on statin intensity as low, moderate, and high. The study endpoint was CKD progression (composite of doubling of serum creatinine, ≥ 50% decrease in estimated glomerular filtration rate [eGFR] from baseline, or end-stage renal disease).
Results : : The mean age was 56.0 ± 11.4 years, and 665 (62.0%) participants were male. The mean eGFR was 51.7 ± 26.7 mL/min/1.73 m2; there were no differences in baseline eGFR among statin intensity groups. During the median follow-up of 39.9 (25.4-61.6) months, 255 (23.8%) patients reached the study endpoint. In multivariable Cox model after adjustment of confounders, the hazard ratios (95% confidence interval) for adverse kidney outcome were 0.97 (0.72-1.30) and 1.15 (0.60-2.20) in moderate and high statin intensity groups, respectively, compared with the low intensity group. In addition, no significant association was observed in subgroups stratified by age, sex, eGFR, and atherosclerotic cardiovascular disease risk scores.
Conclusion : : We did not observe any significant association between intensity of statin therapy and progression of CKD. Long-term kidney outcomes may not be affected by statin intensity. |
| first_indexed | 2024-12-20T04:34:12Z |
| format | Article |
| id | doaj.art-ff9d53d7900b42fcabb12b624f5c3362 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 |
| language | English |
| last_indexed | 2024-12-20T04:34:12Z |
| publishDate | 2020-03-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-ff9d53d7900b42fcabb12b624f5c33622022-12-21T19:53:18ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322020-03-013919310210.23876/j.krcp.20.007j.krcp.20.007Intensity of statin therapy and renal outcome in chronic kidney disease: Results from the Korean Cohort Study for Outcome in Patients With Chronic Kidney DiseaseJong Hyun Jhee0Young Su Joo1Jung Tak Park2Tae-Hyun Yoo3Sue Kyung Park4Ji Yong Jung5Soo Wan Kim6Yun Kyu Oh7Kook-Hwan Oh8Shin-Wook Kang9Kyu Hun Choi10Curie Ahn11Seung Hyeok Han12Division of Nephrology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of KoreaDivision of Nephrology, Department of Internal Medicine, Myongji Hospital, Goyang, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Republic of KoreaDepartment of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of KoreaDivision of Nephrology, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Republic of KoreaDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, Republic of KoreaDepartment of Internal Medicine, SMG-SNU Boramae Medical Center, Seoul, Republic of KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Republic of KoreaDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Republic of KoreaDepartment of Internal Medicine, College of Medicine, Institute of Kidney Disease Research, Yonsei University, Seoul, Republic of KoreaBackground : : Higher statin intensity is associated with a lower risk of mortality in patients with cardiovascular disease. However, little is known about the relationship between statin intensity and chronic kidney disease (CKD) progression. Methods : : We studied whether statin intensity affects kidney function decline in 1,073 patients from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease. The participants were classified based on statin intensity as low, moderate, and high. The study endpoint was CKD progression (composite of doubling of serum creatinine, ≥ 50% decrease in estimated glomerular filtration rate [eGFR] from baseline, or end-stage renal disease). Results : : The mean age was 56.0 ± 11.4 years, and 665 (62.0%) participants were male. The mean eGFR was 51.7 ± 26.7 mL/min/1.73 m2; there were no differences in baseline eGFR among statin intensity groups. During the median follow-up of 39.9 (25.4-61.6) months, 255 (23.8%) patients reached the study endpoint. In multivariable Cox model after adjustment of confounders, the hazard ratios (95% confidence interval) for adverse kidney outcome were 0.97 (0.72-1.30) and 1.15 (0.60-2.20) in moderate and high statin intensity groups, respectively, compared with the low intensity group. In addition, no significant association was observed in subgroups stratified by age, sex, eGFR, and atherosclerotic cardiovascular disease risk scores. Conclusion : : We did not observe any significant association between intensity of statin therapy and progression of CKD. Long-term kidney outcomes may not be affected by statin intensity.https://doi.org/10.23876/j.krcp.20.007chronic kidney diseasedisease progressionintensitystatin |
| spellingShingle | Jong Hyun Jhee Young Su Joo Jung Tak Park Tae-Hyun Yoo Sue Kyung Park Ji Yong Jung Soo Wan Kim Yun Kyu Oh Kook-Hwan Oh Shin-Wook Kang Kyu Hun Choi Curie Ahn Seung Hyeok Han Intensity of statin therapy and renal outcome in chronic kidney disease: Results from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease Kidney Research and Clinical Practice chronic kidney disease disease progression intensity statin |
| title | Intensity of statin therapy and renal outcome in chronic kidney disease: Results from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease |
| title_full | Intensity of statin therapy and renal outcome in chronic kidney disease: Results from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease |
| title_fullStr | Intensity of statin therapy and renal outcome in chronic kidney disease: Results from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease |
| title_full_unstemmed | Intensity of statin therapy and renal outcome in chronic kidney disease: Results from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease |
| title_short | Intensity of statin therapy and renal outcome in chronic kidney disease: Results from the Korean Cohort Study for Outcome in Patients With Chronic Kidney Disease |
| title_sort | intensity of statin therapy and renal outcome in chronic kidney disease results from the korean cohort study for outcome in patients with chronic kidney disease |
| topic | chronic kidney disease disease progression intensity statin |
| url | https://doi.org/10.23876/j.krcp.20.007 |
| work_keys_str_mv | AT jonghyunjhee intensityofstatintherapyandrenaloutcomeinchronickidneydiseaseresultsfromthekoreancohortstudyforoutcomeinpatientswithchronickidneydisease AT youngsujoo intensityofstatintherapyandrenaloutcomeinchronickidneydiseaseresultsfromthekoreancohortstudyforoutcomeinpatientswithchronickidneydisease AT jungtakpark intensityofstatintherapyandrenaloutcomeinchronickidneydiseaseresultsfromthekoreancohortstudyforoutcomeinpatientswithchronickidneydisease AT taehyunyoo intensityofstatintherapyandrenaloutcomeinchronickidneydiseaseresultsfromthekoreancohortstudyforoutcomeinpatientswithchronickidneydisease AT suekyungpark intensityofstatintherapyandrenaloutcomeinchronickidneydiseaseresultsfromthekoreancohortstudyforoutcomeinpatientswithchronickidneydisease AT jiyongjung intensityofstatintherapyandrenaloutcomeinchronickidneydiseaseresultsfromthekoreancohortstudyforoutcomeinpatientswithchronickidneydisease AT soowankim intensityofstatintherapyandrenaloutcomeinchronickidneydiseaseresultsfromthekoreancohortstudyforoutcomeinpatientswithchronickidneydisease AT yunkyuoh intensityofstatintherapyandrenaloutcomeinchronickidneydiseaseresultsfromthekoreancohortstudyforoutcomeinpatientswithchronickidneydisease AT kookhwanoh intensityofstatintherapyandrenaloutcomeinchronickidneydiseaseresultsfromthekoreancohortstudyforoutcomeinpatientswithchronickidneydisease AT shinwookkang intensityofstatintherapyandrenaloutcomeinchronickidneydiseaseresultsfromthekoreancohortstudyforoutcomeinpatientswithchronickidneydisease AT kyuhunchoi intensityofstatintherapyandrenaloutcomeinchronickidneydiseaseresultsfromthekoreancohortstudyforoutcomeinpatientswithchronickidneydisease AT curieahn intensityofstatintherapyandrenaloutcomeinchronickidneydiseaseresultsfromthekoreancohortstudyforoutcomeinpatientswithchronickidneydisease AT seunghyeokhan intensityofstatintherapyandrenaloutcomeinchronickidneydiseaseresultsfromthekoreancohortstudyforoutcomeinpatientswithchronickidneydisease |