Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence
Background: Sensitization in early childhood may precede respiratory allergy in adolescence. Methods: IgE reactivity against 132 allergen molecules was evaluated using the MeDALL microarray in sera obtained from a random sample of 786 children at the age of 4, 8 and 16 years in a population based bi...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2017-12-01
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| Series: | EBioMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396417304528 |
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| author | Magnus Wickman Christian Lupinek Niklas Andersson Danielle Belgrave Anna Asarnoj Marta Benet Mariona Pinart Sandra Wieser Judith Garcia-Aymerich Alexandra Baar Göran Pershagen Angela Simpson Inger Kull Anna Bergström Erik Melén Carl Hamsten Josep M. Antó Jean Bousquet Adnan Custovic Rudolf Valenta Marianne van Hage |
| author_facet | Magnus Wickman Christian Lupinek Niklas Andersson Danielle Belgrave Anna Asarnoj Marta Benet Mariona Pinart Sandra Wieser Judith Garcia-Aymerich Alexandra Baar Göran Pershagen Angela Simpson Inger Kull Anna Bergström Erik Melén Carl Hamsten Josep M. Antó Jean Bousquet Adnan Custovic Rudolf Valenta Marianne van Hage |
| author_sort | Magnus Wickman |
| collection | DOAJ |
| description | Background: Sensitization in early childhood may precede respiratory allergy in adolescence.
Methods: IgE reactivity against 132 allergen molecules was evaluated using the MeDALL microarray in sera obtained from a random sample of 786 children at the age of 4, 8 and 16 years in a population based birth cohort (BAMSE). Symptoms were analyzed by questionnaire at ages 4, 8 and 16 years. Clinically and independent relevant allergen molecules accounting for ≥90% of IgE reactivities in sensitized individuals and at all time-points were identified as risk molecules and used to predict respiratory allergy. The data was replicated in the Manchester Asthma and Allergy Study (MAAS) birth cohort by studying IgE reactivity with the use of a commercial IgE microarray. Sera were obtained from children at the ages of 3, 5, 8 and 11 years (N = 248) and the outcome was studied at 11 years.
Findings: In the BAMSE cohort 4 risk molecules could be identified, i.e.: Ara h 1 (peanut), Bet v 1 (birch), Fel d 1 (cat), Phl p 1 (grass). For MAAS the corresponding number of molecules was 5: Der p 1 (dust mite), Der f 2 (dust mite), Phl p 1 (grass), Phl p 5 (grass), Fel d 1 (cat). In BAMSE, early IgE reactivity to ≥3 of 4 allergen molecules at four years predicted incident and persistent asthma and/or rhinitis at 16 years (87% and 95%, respectively). The corresponding proportions in the MAAS cohort at 16 years were 100% and 100%, respectively, for IgE reactivity to ≥3 of 5 risk molecules.
Interpretations: IgE reactivity to a few allergen molecules early in life identifies children with a high risk of asthma and/or rhinitis at 16 years. These findings will be of importance for developing preventive strategies for asthma and rhinitis in children. |
| first_indexed | 2024-12-11T07:46:35Z |
| format | Article |
| id | doaj.art-ff9e584d52aa45b1a9305dc48a54ba7a |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-12-11T07:46:35Z |
| publishDate | 2017-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-ff9e584d52aa45b1a9305dc48a54ba7a2022-12-22T01:15:27ZengElsevierEBioMedicine2352-39642017-12-0126C919910.1016/j.ebiom.2017.11.009Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in AdolescenceMagnus Wickman0Christian Lupinek1Niklas Andersson2Danielle Belgrave3Anna Asarnoj4Marta Benet5Mariona Pinart6Sandra Wieser7Judith Garcia-Aymerich8Alexandra Baar9Göran Pershagen10Angela Simpson11Inger Kull12Anna Bergström13Erik Melén14Carl Hamsten15Josep M. Antó16Jean Bousquet17Adnan Custovic18Rudolf Valenta19Marianne van Hage20Institute of Environmental Medicine, Karolinska Institutet and Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, SwedenDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, AustriaInstitute of Environmental Medicine, Karolinska Institutet and Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, SwedenDepartment of Paediatrics, Imperial College, London, UKImmunology and Allergy Unit, Department of Medicine, Karolinska Institutet, and Karolinska University Hospital, Stockholm, SwedenISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, SpainISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, SpainDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, AustriaISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, SpainDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, AustriaInstitute of Environmental Medicine, Karolinska Institutet and Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, SwedenDivision of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, UKInstitute of Environmental Medicine, Karolinska Institutet and Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, SwedenInstitute of Environmental Medicine, Karolinska Institutet and Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, SwedenInstitute of Environmental Medicine, Karolinska Institutet and Centre for Occupational and Environmental Medicine, Stockholm County Council, Stockholm, SwedenImmunology and Allergy Unit, Department of Medicine, Karolinska Institutet, and Karolinska University Hospital, Stockholm, SwedenISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, SpainUniversity Hospital, Montpellier; INSERM, VIMA: Ageing and chronic diseases, FranceDepartment of Paediatrics, Imperial College, London, UKDivision of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, AustriaImmunology and Allergy Unit, Department of Medicine, Karolinska Institutet, and Karolinska University Hospital, Stockholm, SwedenBackground: Sensitization in early childhood may precede respiratory allergy in adolescence. Methods: IgE reactivity against 132 allergen molecules was evaluated using the MeDALL microarray in sera obtained from a random sample of 786 children at the age of 4, 8 and 16 years in a population based birth cohort (BAMSE). Symptoms were analyzed by questionnaire at ages 4, 8 and 16 years. Clinically and independent relevant allergen molecules accounting for ≥90% of IgE reactivities in sensitized individuals and at all time-points were identified as risk molecules and used to predict respiratory allergy. The data was replicated in the Manchester Asthma and Allergy Study (MAAS) birth cohort by studying IgE reactivity with the use of a commercial IgE microarray. Sera were obtained from children at the ages of 3, 5, 8 and 11 years (N = 248) and the outcome was studied at 11 years. Findings: In the BAMSE cohort 4 risk molecules could be identified, i.e.: Ara h 1 (peanut), Bet v 1 (birch), Fel d 1 (cat), Phl p 1 (grass). For MAAS the corresponding number of molecules was 5: Der p 1 (dust mite), Der f 2 (dust mite), Phl p 1 (grass), Phl p 5 (grass), Fel d 1 (cat). In BAMSE, early IgE reactivity to ≥3 of 4 allergen molecules at four years predicted incident and persistent asthma and/or rhinitis at 16 years (87% and 95%, respectively). The corresponding proportions in the MAAS cohort at 16 years were 100% and 100%, respectively, for IgE reactivity to ≥3 of 5 risk molecules. Interpretations: IgE reactivity to a few allergen molecules early in life identifies children with a high risk of asthma and/or rhinitis at 16 years. These findings will be of importance for developing preventive strategies for asthma and rhinitis in children.http://www.sciencedirect.com/science/article/pii/S2352396417304528AsthmaIgEPredictionRhinitisSensitisation |
| spellingShingle | Magnus Wickman Christian Lupinek Niklas Andersson Danielle Belgrave Anna Asarnoj Marta Benet Mariona Pinart Sandra Wieser Judith Garcia-Aymerich Alexandra Baar Göran Pershagen Angela Simpson Inger Kull Anna Bergström Erik Melén Carl Hamsten Josep M. Antó Jean Bousquet Adnan Custovic Rudolf Valenta Marianne van Hage Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence EBioMedicine Asthma IgE Prediction Rhinitis Sensitisation |
| title | Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence |
| title_full | Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence |
| title_fullStr | Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence |
| title_full_unstemmed | Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence |
| title_short | Detection of IgE Reactivity to a Handful of Allergen Molecules in Early Childhood Predicts Respiratory Allergy in Adolescence |
| title_sort | detection of ige reactivity to a handful of allergen molecules in early childhood predicts respiratory allergy in adolescence |
| topic | Asthma IgE Prediction Rhinitis Sensitisation |
| url | http://www.sciencedirect.com/science/article/pii/S2352396417304528 |
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