Titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants
In an attempt to combat the possibility of bacterial infection and insufficient bone growth around metallic, surgical implants, bioactive glasses may be employed as coatings. In this work, silica-based and borate-based glass series were synthesized for this purpose and subsequently characterized in...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-10-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844017304917 |
| _version_ | 1828851407268085760 |
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| author | Omar Rodriguez Wendy Stone Emil H. Schemitsch Paul Zalzal Stephen Waldman Marcello Papini Mark R. Towler |
| author_facet | Omar Rodriguez Wendy Stone Emil H. Schemitsch Paul Zalzal Stephen Waldman Marcello Papini Mark R. Towler |
| author_sort | Omar Rodriguez |
| collection | DOAJ |
| description | In an attempt to combat the possibility of bacterial infection and insufficient bone growth around metallic, surgical implants, bioactive glasses may be employed as coatings. In this work, silica-based and borate-based glass series were synthesized for this purpose and subsequently characterized in terms of antibacterial behavior, solubility and cytotoxicity. Borate-based glasses were found to exhibit significantly superior antibacterial properties and increased solubility compared to their silica-based counterparts, with BRT0 and BRT3 (borate-based glasses with 0 and 15 mol% of titanium dioxide incorporated, respectively) outperforming the remainder of the glasses, both borate and silicate based, in these respects. Atomic Absorption Spectroscopy confirmed the release of zinc ions (Zn2+), which has been linked to the antibacterial abilities of glasses SRT0, BRT0 and BRT3, with inhibition effectively achieved at concentrations lower than 0.7 ppm. In vitro cytotoxicity studies using MC3T3-E1 osteoblasts confirmed that cell proliferation was affected by all glasses in this study, with decreased proliferation attributed to a faster release of sodium ions over calcium ions in both glass series, factor known to slow cell proliferation in vitro. |
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| format | Article |
| id | doaj.art-ff9eadf5443b44e4abb4b803aa1d06f5 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-12T23:31:17Z |
| publishDate | 2017-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-ff9eadf5443b44e4abb4b803aa1d06f52022-12-22T00:07:46ZengElsevierHeliyon2405-84402017-10-01310e00420Titanium addition influences antibacterial activity of bioactive glass coatings on metallic implantsOmar Rodriguez0Wendy Stone1Emil H. Schemitsch2Paul Zalzal3Stephen Waldman4Marcello Papini5Mark R. Towler6Department of Mechanical & Industrial Engineering, Ryerson University, Toronto M5B 2K3, Ontario, Canada; St. Michael’s Hospital, Toronto M5B 1W8, Ontario, Canada; Corresponding author at:Department of Chemistry and Biology, Ryerson University, Toronto M5B 2K3, Ontario, CanadaSt. Michael’s Hospital, Toronto M5B 1W8, Ontario, Canada; Department of Surgery, University of Western Ontario, London, ON N6A 4V2, CanadaOakville Trafalgar Memorial Hospital, Oakville L6J 3L7, Ontario, Canada; Faculty of Health Sciences, Department of Surgery, McMaster University, Hamilton L8S 4L8, Ontario, CanadaSt. Michael’s Hospital, Toronto M5B 1W8, Ontario, Canada; Department of Chemical Engineering, Ryerson University, Toronto M5B 2K3, Ontario, CanadaDepartment of Mechanical & Industrial Engineering, Ryerson University, Toronto M5B 2K3, Ontario, CanadaDepartment of Mechanical & Industrial Engineering, Ryerson University, Toronto M5B 2K3, Ontario, Canada; St. Michael’s Hospital, Toronto M5B 1W8, Ontario, Canada; Department of Biomedical Engineering, University of Malaya, Kuala Lumpur, MalaysiaIn an attempt to combat the possibility of bacterial infection and insufficient bone growth around metallic, surgical implants, bioactive glasses may be employed as coatings. In this work, silica-based and borate-based glass series were synthesized for this purpose and subsequently characterized in terms of antibacterial behavior, solubility and cytotoxicity. Borate-based glasses were found to exhibit significantly superior antibacterial properties and increased solubility compared to their silica-based counterparts, with BRT0 and BRT3 (borate-based glasses with 0 and 15 mol% of titanium dioxide incorporated, respectively) outperforming the remainder of the glasses, both borate and silicate based, in these respects. Atomic Absorption Spectroscopy confirmed the release of zinc ions (Zn2+), which has been linked to the antibacterial abilities of glasses SRT0, BRT0 and BRT3, with inhibition effectively achieved at concentrations lower than 0.7 ppm. In vitro cytotoxicity studies using MC3T3-E1 osteoblasts confirmed that cell proliferation was affected by all glasses in this study, with decreased proliferation attributed to a faster release of sodium ions over calcium ions in both glass series, factor known to slow cell proliferation in vitro.http://www.sciencedirect.com/science/article/pii/S2405844017304917Biomedical engineeringMaterials science |
| spellingShingle | Omar Rodriguez Wendy Stone Emil H. Schemitsch Paul Zalzal Stephen Waldman Marcello Papini Mark R. Towler Titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants Heliyon Biomedical engineering Materials science |
| title | Titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants |
| title_full | Titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants |
| title_fullStr | Titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants |
| title_full_unstemmed | Titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants |
| title_short | Titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants |
| title_sort | titanium addition influences antibacterial activity of bioactive glass coatings on metallic implants |
| topic | Biomedical engineering Materials science |
| url | http://www.sciencedirect.com/science/article/pii/S2405844017304917 |
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