Exosomes and cancer immunotherapy: A review of recent cancer research
As phospholipid extracellular vesicles (EVs) secreted by various cells, exosomes contain non-coding RNA (ncRNA), mRNA, DNA fragments, lipids, and proteins, which are essential for intercellular communication. Several types of cells can secrete exosomes that contribute to cancer initiation and progre...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1118101/full |
| _version_ | 1797951973557796864 |
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| author | Yue Cao Peng Xu Yangling Shen Wei Wu Min Chen Fei Wang Yuandong Zhu Feng Yan Weiying Gu Yan Lin |
| author_facet | Yue Cao Peng Xu Yangling Shen Wei Wu Min Chen Fei Wang Yuandong Zhu Feng Yan Weiying Gu Yan Lin |
| author_sort | Yue Cao |
| collection | DOAJ |
| description | As phospholipid extracellular vesicles (EVs) secreted by various cells, exosomes contain non-coding RNA (ncRNA), mRNA, DNA fragments, lipids, and proteins, which are essential for intercellular communication. Several types of cells can secrete exosomes that contribute to cancer initiation and progression. Cancer cells and the immune microenvironment interact and restrict each other. Tumor-derived exosomes (TDEs) have become essential players in this balance because they carry information from the original cancer cells and express complexes of MHC class I/II epitopes and costimulatory molecules. In the present study, we aimed to identify potential targets for exosome therapy by examining the specific expression and mechanism of exosomes derived from cancer cells. We introduced TDEs and explored their role in different tumor immune microenvironment (TIME), with a particular emphasis on gastrointestinal cancers, before briefly describing the therapeutic strategies of exosomes in cancer immune-related therapy. |
| first_indexed | 2024-04-10T22:39:02Z |
| format | Article |
| id | doaj.art-ff9f2478c4224ce3a29dcd836742b0ff |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T22:39:02Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-ff9f2478c4224ce3a29dcd836742b0ff2023-01-16T09:04:27ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-01-011210.3389/fonc.2022.11181011118101Exosomes and cancer immunotherapy: A review of recent cancer researchYue Cao0Peng Xu1Yangling Shen2Wei Wu3Min Chen4Fei Wang5Yuandong Zhu6Feng Yan7Weiying Gu8Yan Lin9Department of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Hematology, Soochow Hopes Hematology Hospital, Suzhou, Jiangsu, ChinaDepartment of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaAs phospholipid extracellular vesicles (EVs) secreted by various cells, exosomes contain non-coding RNA (ncRNA), mRNA, DNA fragments, lipids, and proteins, which are essential for intercellular communication. Several types of cells can secrete exosomes that contribute to cancer initiation and progression. Cancer cells and the immune microenvironment interact and restrict each other. Tumor-derived exosomes (TDEs) have become essential players in this balance because they carry information from the original cancer cells and express complexes of MHC class I/II epitopes and costimulatory molecules. In the present study, we aimed to identify potential targets for exosome therapy by examining the specific expression and mechanism of exosomes derived from cancer cells. We introduced TDEs and explored their role in different tumor immune microenvironment (TIME), with a particular emphasis on gastrointestinal cancers, before briefly describing the therapeutic strategies of exosomes in cancer immune-related therapy.https://www.frontiersin.org/articles/10.3389/fonc.2022.1118101/fullextracellular vesicleexosometumor immune microenvironmentgastrointestinal cancerimmunotherapy |
| spellingShingle | Yue Cao Peng Xu Yangling Shen Wei Wu Min Chen Fei Wang Yuandong Zhu Feng Yan Weiying Gu Yan Lin Exosomes and cancer immunotherapy: A review of recent cancer research Frontiers in Oncology extracellular vesicle exosome tumor immune microenvironment gastrointestinal cancer immunotherapy |
| title | Exosomes and cancer immunotherapy: A review of recent cancer research |
| title_full | Exosomes and cancer immunotherapy: A review of recent cancer research |
| title_fullStr | Exosomes and cancer immunotherapy: A review of recent cancer research |
| title_full_unstemmed | Exosomes and cancer immunotherapy: A review of recent cancer research |
| title_short | Exosomes and cancer immunotherapy: A review of recent cancer research |
| title_sort | exosomes and cancer immunotherapy a review of recent cancer research |
| topic | extracellular vesicle exosome tumor immune microenvironment gastrointestinal cancer immunotherapy |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1118101/full |
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