Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points

Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points

Abstract Background Enhancers and promoters are cis-acting regulatory elements associated with lineage-specific gene expression. Previous studies showed that different categories of active regulatory elements are in regions of open chromatin, and each category is associated with a specific subset of...

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Bibliographic Details
Main Authors: Elisabeth F. Heuston, Cheryl A. Keller, Jens Lichtenberg, Belinda Giardine, Stacie M. Anderson, NIH Intramural Sequencing Center, Ross C. Hardison, David M. Bodine
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Epigenetics & Chromatin
Subjects:
Hematopoiesis
Megakaryopoiesis
Erythropoiesis
ATAC-Seq
RNA-Seq
ChIP-Seq
Online Access:http://link.springer.com/article/10.1186/s13072-018-0195-z

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