Efficacy and safety of Yunkang oral liquid combined with conventional therapy for threatened miscarriage of first-trimester pregnancy a protocol for systematic review and meta-analysis.
<h4>Introduction</h4>Threatened miscarriages is a common complication of first-trimester pregnancy. Due to the beneficial effects, there are increasing clinical studies on Yunkang oral liquid(YKOL). However, the efficacy and safety of YKOL are still unknown. The aim of this systematic re...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2022-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0263581 |
| _version_ | 1797743352040390656 |
|---|---|
| author | Peng Sun Liping Tang Dongmei Yan Bin Li Lingxia Xu Fei Wang |
| author_facet | Peng Sun Liping Tang Dongmei Yan Bin Li Lingxia Xu Fei Wang |
| author_sort | Peng Sun |
| collection | DOAJ |
| description | <h4>Introduction</h4>Threatened miscarriages is a common complication of first-trimester pregnancy. Due to the beneficial effects, there are increasing clinical studies on Yunkang oral liquid(YKOL). However, the efficacy and safety of YKOL are still unknown. The aim of this systematic review was to assess the efficacy and safety of YKOL in the treatment of threatened miscarriage during the first-trimester pregnancy (TMFP).<h4>Methods</h4>This protocol will be prepared according to the preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) statement. The systematic review will include all randomized controlled trials (RCTs) studies published until April 2021. Electronic sources including CNKI, WF, VIP, CBM, MEDLINE(PubMed), Embase, Cochrane Library, and Web of Science will be searched for potentially eligible studies. The international clinical trial registration platform and the Chinese clinical trial registration platform of controlled trials will be searched from their inception until April 1st, 2021. According to the inclusion and exclusion criteria, screening literature, extraction data will be conducted by two researchers independently. Statistical analysis will use RevMan 5.3.5 software. The strength of evidence from the studies will be evaluated with the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) methods.<h4>Results</h4>This study will provide evidence for YKOL combined with conventional therapy for TMFP.<h4>Conclusion</h4>The efficacy and safety of YKOL combined with conventional therapy for TMFP will be assessed.<h4>Systematic review registration</h4>INPLASY202140105 (https://www.doi.org/10.37766/inplasy2021.4.0105). |
| first_indexed | 2024-03-12T14:54:15Z |
| format | Article |
| id | doaj.art-ffa0dffb3ac9433182ff1454b3669b4e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-12T14:54:15Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-ffa0dffb3ac9433182ff1454b3669b4e2023-08-15T05:31:46ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01172e026358110.1371/journal.pone.0263581Efficacy and safety of Yunkang oral liquid combined with conventional therapy for threatened miscarriage of first-trimester pregnancy a protocol for systematic review and meta-analysis.Peng SunLiping TangDongmei YanBin LiLingxia XuFei Wang<h4>Introduction</h4>Threatened miscarriages is a common complication of first-trimester pregnancy. Due to the beneficial effects, there are increasing clinical studies on Yunkang oral liquid(YKOL). However, the efficacy and safety of YKOL are still unknown. The aim of this systematic review was to assess the efficacy and safety of YKOL in the treatment of threatened miscarriage during the first-trimester pregnancy (TMFP).<h4>Methods</h4>This protocol will be prepared according to the preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) statement. The systematic review will include all randomized controlled trials (RCTs) studies published until April 2021. Electronic sources including CNKI, WF, VIP, CBM, MEDLINE(PubMed), Embase, Cochrane Library, and Web of Science will be searched for potentially eligible studies. The international clinical trial registration platform and the Chinese clinical trial registration platform of controlled trials will be searched from their inception until April 1st, 2021. According to the inclusion and exclusion criteria, screening literature, extraction data will be conducted by two researchers independently. Statistical analysis will use RevMan 5.3.5 software. The strength of evidence from the studies will be evaluated with the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) methods.<h4>Results</h4>This study will provide evidence for YKOL combined with conventional therapy for TMFP.<h4>Conclusion</h4>The efficacy and safety of YKOL combined with conventional therapy for TMFP will be assessed.<h4>Systematic review registration</h4>INPLASY202140105 (https://www.doi.org/10.37766/inplasy2021.4.0105).https://doi.org/10.1371/journal.pone.0263581 |
| spellingShingle | Peng Sun Liping Tang Dongmei Yan Bin Li Lingxia Xu Fei Wang Efficacy and safety of Yunkang oral liquid combined with conventional therapy for threatened miscarriage of first-trimester pregnancy a protocol for systematic review and meta-analysis. PLoS ONE |
| title | Efficacy and safety of Yunkang oral liquid combined with conventional therapy for threatened miscarriage of first-trimester pregnancy a protocol for systematic review and meta-analysis. |
| title_full | Efficacy and safety of Yunkang oral liquid combined with conventional therapy for threatened miscarriage of first-trimester pregnancy a protocol for systematic review and meta-analysis. |
| title_fullStr | Efficacy and safety of Yunkang oral liquid combined with conventional therapy for threatened miscarriage of first-trimester pregnancy a protocol for systematic review and meta-analysis. |
| title_full_unstemmed | Efficacy and safety of Yunkang oral liquid combined with conventional therapy for threatened miscarriage of first-trimester pregnancy a protocol for systematic review and meta-analysis. |
| title_short | Efficacy and safety of Yunkang oral liquid combined with conventional therapy for threatened miscarriage of first-trimester pregnancy a protocol for systematic review and meta-analysis. |
| title_sort | efficacy and safety of yunkang oral liquid combined with conventional therapy for threatened miscarriage of first trimester pregnancy a protocol for systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0263581 |
| work_keys_str_mv | AT pengsun efficacyandsafetyofyunkangoralliquidcombinedwithconventionaltherapyforthreatenedmiscarriageoffirsttrimesterpregnancyaprotocolforsystematicreviewandmetaanalysis AT lipingtang efficacyandsafetyofyunkangoralliquidcombinedwithconventionaltherapyforthreatenedmiscarriageoffirsttrimesterpregnancyaprotocolforsystematicreviewandmetaanalysis AT dongmeiyan efficacyandsafetyofyunkangoralliquidcombinedwithconventionaltherapyforthreatenedmiscarriageoffirsttrimesterpregnancyaprotocolforsystematicreviewandmetaanalysis AT binli efficacyandsafetyofyunkangoralliquidcombinedwithconventionaltherapyforthreatenedmiscarriageoffirsttrimesterpregnancyaprotocolforsystematicreviewandmetaanalysis AT lingxiaxu efficacyandsafetyofyunkangoralliquidcombinedwithconventionaltherapyforthreatenedmiscarriageoffirsttrimesterpregnancyaprotocolforsystematicreviewandmetaanalysis AT feiwang efficacyandsafetyofyunkangoralliquidcombinedwithconventionaltherapyforthreatenedmiscarriageoffirsttrimesterpregnancyaprotocolforsystematicreviewandmetaanalysis |