Literature Values of Terminal Half-Lives of Clozapine are Dependent on the Time of the Last Data Point
The pharmacokinetics of clozapine is a subject of intensive research because of its narrow therapeutic window and susceptibility to drug-drug interactions. A systematic literature search was conducted in PubMed and Google Scholar for half-life values of clozapine in humans. Twenty-one publications w...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-04-01
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| Series: | Journal of Pharmacy & Pharmaceutical Sciences |
| Online Access: | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/21108 |
| _version_ | 1797726830575222784 |
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| author | Jim Fang Karen Mosier |
| author_facet | Jim Fang Karen Mosier |
| author_sort | Jim Fang |
| collection | DOAJ |
| description | The pharmacokinetics of clozapine is a subject of intensive research because of its narrow therapeutic window and susceptibility to drug-drug interactions. A systematic literature search was conducted in PubMed and Google Scholar for half-life values of clozapine in humans. Twenty-one publications were found to contain terminal half-life information of clozapine in humans along with the time of the last plasma sample. Average values of the terminal half-lives of clozapine were calculated to be 10.2, 13.2, 14.2, 18.3 and 29.2 hours with a last data point at 12, 24, 48, 72 and 120 hours, respectively. This confirms the notion that one would arrive at longer terminal half-lives when longer blood sampling times are used in pharmacokinetic studies on clozapine. “Terminal half-lives” of therapeutic agent are routinely computed and reported in literature. For drugs with a third deep compartment such as clozapine, one should remember to consider the time of the last data point when comparing the “terminal” half-life. |
| first_indexed | 2024-03-12T10:51:08Z |
| format | Article |
| id | doaj.art-ffa39616bcf7482ebd339a9c52b97308 |
| institution | Directory Open Access Journal |
| issn | 1482-1826 |
| language | English |
| last_indexed | 2024-03-12T10:51:08Z |
| publishDate | 2014-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmaceutical Sciences |
| spelling | doaj.art-ffa39616bcf7482ebd339a9c52b973082023-09-02T06:59:18ZengFrontiers Media S.A.Journal of Pharmacy & Pharmaceutical Sciences1482-18262014-04-0117210.18433/J3KC7PLiterature Values of Terminal Half-Lives of Clozapine are Dependent on the Time of the Last Data PointJim Fang0Karen Mosier1University of SaskatchewanUniversity of SaskatchewanThe pharmacokinetics of clozapine is a subject of intensive research because of its narrow therapeutic window and susceptibility to drug-drug interactions. A systematic literature search was conducted in PubMed and Google Scholar for half-life values of clozapine in humans. Twenty-one publications were found to contain terminal half-life information of clozapine in humans along with the time of the last plasma sample. Average values of the terminal half-lives of clozapine were calculated to be 10.2, 13.2, 14.2, 18.3 and 29.2 hours with a last data point at 12, 24, 48, 72 and 120 hours, respectively. This confirms the notion that one would arrive at longer terminal half-lives when longer blood sampling times are used in pharmacokinetic studies on clozapine. “Terminal half-lives” of therapeutic agent are routinely computed and reported in literature. For drugs with a third deep compartment such as clozapine, one should remember to consider the time of the last data point when comparing the “terminal” half-life.https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/21108 |
| spellingShingle | Jim Fang Karen Mosier Literature Values of Terminal Half-Lives of Clozapine are Dependent on the Time of the Last Data Point Journal of Pharmacy & Pharmaceutical Sciences |
| title | Literature Values of Terminal Half-Lives of Clozapine are Dependent on the Time of the Last Data Point |
| title_full | Literature Values of Terminal Half-Lives of Clozapine are Dependent on the Time of the Last Data Point |
| title_fullStr | Literature Values of Terminal Half-Lives of Clozapine are Dependent on the Time of the Last Data Point |
| title_full_unstemmed | Literature Values of Terminal Half-Lives of Clozapine are Dependent on the Time of the Last Data Point |
| title_short | Literature Values of Terminal Half-Lives of Clozapine are Dependent on the Time of the Last Data Point |
| title_sort | literature values of terminal half lives of clozapine are dependent on the time of the last data point |
| url | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/21108 |
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