Clinical Significance of Gamma-Glutamyltranspeptidase Combined with Carbohydrate-Deficient Transferrin for the Assessment of Excessive Alcohol Consumption in Patients with Alcoholic Cirrhosis
<b>Background:</b> This study aimed to compare the diagnostic performance of carbohydrate-deficient transferrin (CDT) and gamma-glutamyltranspeptidase (γ-GTP) to assess the single and combined benefits of these biological markers for the detection of chronic excessive alcohol consumption...
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MDPI AG
2021-07-01
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| author | Akihiko Shibamoto Tadashi Namisaki Junya Suzuki Takahiro Kubo Satoshi Iwai Fumimasa Tomooka Soichi Takeda Yuki Fujimoto Masahide Enomoto Koji Murata Takashi Inoue Koji Ishida Hiroyuki Ogawa Hirotetsu Takagi Daisuke Kaya Yuki Tsuji Takahiro Ozutsumi Yukihisa Fujinaga Masanori Furukawa Norihisa Nishimura Yasuhiko Sawada Koh Kitagawa Shinya Sato Hiroaki Takaya Kosuke Kaji Naotaka Shimozato Hideto Kawaratani Kei Moriya Takemi Akahane Akira Mitoro Hitoshi Yoshiji |
| author_facet | Akihiko Shibamoto Tadashi Namisaki Junya Suzuki Takahiro Kubo Satoshi Iwai Fumimasa Tomooka Soichi Takeda Yuki Fujimoto Masahide Enomoto Koji Murata Takashi Inoue Koji Ishida Hiroyuki Ogawa Hirotetsu Takagi Daisuke Kaya Yuki Tsuji Takahiro Ozutsumi Yukihisa Fujinaga Masanori Furukawa Norihisa Nishimura Yasuhiko Sawada Koh Kitagawa Shinya Sato Hiroaki Takaya Kosuke Kaji Naotaka Shimozato Hideto Kawaratani Kei Moriya Takemi Akahane Akira Mitoro Hitoshi Yoshiji |
| author_sort | Akihiko Shibamoto |
| collection | DOAJ |
| description | <b>Background:</b> This study aimed to compare the diagnostic performance of carbohydrate-deficient transferrin (CDT) and gamma-glutamyltranspeptidase (γ-GTP) to assess the single and combined benefits of these biological markers for the detection of chronic excessive alcohol consumption in patients with alcoholic cirrhosis. <b>Methods:</b> Biological markers were determined in blood samples from patients with alcoholic cirrhosis (drinking group, <i>n</i> = 35; nondrinking group, <i>n</i> = 81). The prediction accuracy of %CDT alone, γ-GTP alone, and their combination for the detection of excessive alcohol consumption was determined in patients with alcoholic cirrhosis. <b>Results:</b> Serum total bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-GTP, and alkaline phosphatase levels and %CDT were significantly higher and serum albumin levels were significantly lower in the drinking group than in the nondrinking group. The combination of %CDT and γ-GTP compared with %CDT or γ-GTP alone showed a higher prediction accuracy. The combination of %CDT and γ-GTP exhibited a higher specificity than γ-GTP alone. However, in terms of sensitivity, no significant difference was found between single or combined markers. <b>Conclusions:</b> The combination of %CDT and γ-GTP is considered a useful biomarker of chronic excessive alcohol consumption in patients with alcoholic cirrhosis. |
| first_indexed | 2024-03-10T09:33:00Z |
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| id | doaj.art-ffa3ccf2079c47a6ba0a09f9418393a1 |
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| issn | 2305-6320 |
| language | English |
| last_indexed | 2024-03-10T09:33:00Z |
| publishDate | 2021-07-01 |
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| series | Medicines |
| spelling | doaj.art-ffa3ccf2079c47a6ba0a09f9418393a12023-11-22T04:21:59ZengMDPI AGMedicines2305-63202021-07-01873910.3390/medicines8070039Clinical Significance of Gamma-Glutamyltranspeptidase Combined with Carbohydrate-Deficient Transferrin for the Assessment of Excessive Alcohol Consumption in Patients with Alcoholic CirrhosisAkihiko Shibamoto0Tadashi Namisaki1Junya Suzuki2Takahiro Kubo3Satoshi Iwai4Fumimasa Tomooka5Soichi Takeda6Yuki Fujimoto7Masahide Enomoto8Koji Murata9Takashi Inoue10Koji Ishida11Hiroyuki Ogawa12Hirotetsu Takagi13Daisuke Kaya14Yuki Tsuji15Takahiro Ozutsumi16Yukihisa Fujinaga17Masanori Furukawa18Norihisa Nishimura19Yasuhiko Sawada20Koh Kitagawa21Shinya Sato22Hiroaki Takaya23Kosuke Kaji24Naotaka Shimozato25Hideto Kawaratani26Kei Moriya27Takemi Akahane28Akira Mitoro29Hitoshi Yoshiji30Department of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanInstitute for Clinical and Translational Science, Nara Medical University Hospital, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, JapanDepartment of Gastroenterology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8522, Japan<b>Background:</b> This study aimed to compare the diagnostic performance of carbohydrate-deficient transferrin (CDT) and gamma-glutamyltranspeptidase (γ-GTP) to assess the single and combined benefits of these biological markers for the detection of chronic excessive alcohol consumption in patients with alcoholic cirrhosis. <b>Methods:</b> Biological markers were determined in blood samples from patients with alcoholic cirrhosis (drinking group, <i>n</i> = 35; nondrinking group, <i>n</i> = 81). The prediction accuracy of %CDT alone, γ-GTP alone, and their combination for the detection of excessive alcohol consumption was determined in patients with alcoholic cirrhosis. <b>Results:</b> Serum total bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-GTP, and alkaline phosphatase levels and %CDT were significantly higher and serum albumin levels were significantly lower in the drinking group than in the nondrinking group. The combination of %CDT and γ-GTP compared with %CDT or γ-GTP alone showed a higher prediction accuracy. The combination of %CDT and γ-GTP exhibited a higher specificity than γ-GTP alone. However, in terms of sensitivity, no significant difference was found between single or combined markers. <b>Conclusions:</b> The combination of %CDT and γ-GTP is considered a useful biomarker of chronic excessive alcohol consumption in patients with alcoholic cirrhosis.https://www.mdpi.com/2305-6320/8/7/39chronic excessive alcohol consumptionprediction accuracycarbohydrate-deficient transferringamma-glutamyltranspeptidasealcoholic cirrhosis |
| spellingShingle | Akihiko Shibamoto Tadashi Namisaki Junya Suzuki Takahiro Kubo Satoshi Iwai Fumimasa Tomooka Soichi Takeda Yuki Fujimoto Masahide Enomoto Koji Murata Takashi Inoue Koji Ishida Hiroyuki Ogawa Hirotetsu Takagi Daisuke Kaya Yuki Tsuji Takahiro Ozutsumi Yukihisa Fujinaga Masanori Furukawa Norihisa Nishimura Yasuhiko Sawada Koh Kitagawa Shinya Sato Hiroaki Takaya Kosuke Kaji Naotaka Shimozato Hideto Kawaratani Kei Moriya Takemi Akahane Akira Mitoro Hitoshi Yoshiji Clinical Significance of Gamma-Glutamyltranspeptidase Combined with Carbohydrate-Deficient Transferrin for the Assessment of Excessive Alcohol Consumption in Patients with Alcoholic Cirrhosis Medicines chronic excessive alcohol consumption prediction accuracy carbohydrate-deficient transferrin gamma-glutamyltranspeptidase alcoholic cirrhosis |
| title | Clinical Significance of Gamma-Glutamyltranspeptidase Combined with Carbohydrate-Deficient Transferrin for the Assessment of Excessive Alcohol Consumption in Patients with Alcoholic Cirrhosis |
| title_full | Clinical Significance of Gamma-Glutamyltranspeptidase Combined with Carbohydrate-Deficient Transferrin for the Assessment of Excessive Alcohol Consumption in Patients with Alcoholic Cirrhosis |
| title_fullStr | Clinical Significance of Gamma-Glutamyltranspeptidase Combined with Carbohydrate-Deficient Transferrin for the Assessment of Excessive Alcohol Consumption in Patients with Alcoholic Cirrhosis |
| title_full_unstemmed | Clinical Significance of Gamma-Glutamyltranspeptidase Combined with Carbohydrate-Deficient Transferrin for the Assessment of Excessive Alcohol Consumption in Patients with Alcoholic Cirrhosis |
| title_short | Clinical Significance of Gamma-Glutamyltranspeptidase Combined with Carbohydrate-Deficient Transferrin for the Assessment of Excessive Alcohol Consumption in Patients with Alcoholic Cirrhosis |
| title_sort | clinical significance of gamma glutamyltranspeptidase combined with carbohydrate deficient transferrin for the assessment of excessive alcohol consumption in patients with alcoholic cirrhosis |
| topic | chronic excessive alcohol consumption prediction accuracy carbohydrate-deficient transferrin gamma-glutamyltranspeptidase alcoholic cirrhosis |
| url | https://www.mdpi.com/2305-6320/8/7/39 |
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