Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy

Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy

Cholesterol metabolism is often dysregulated in cancer. Squalene monooxygenase (SQLE) is the second rate-limiting enzyme involved in cholesterol synthesis. Since the discovery of SQLE dysregulation in cancer, compelling evidence has indicated that SQLE plays a vital role in cancer initiation and pro...

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Bibliographic Details
Main Authors: Yuheng Zou, Hongying Zhang, Feng Bi, Qiulin Tang, Huanji Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
cancer treatment
cell proliferation and migration
cholesterol metabolism
drug target
squalene epoxidase
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.938502/full

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