Poly (ADP-Ribose) polymerase 1 and parthanatos in neurological diseases: From pathogenesis to therapeutic opportunities

Poly (ADP-Ribose) polymerase 1 and parthanatos in neurological diseases: From pathogenesis to therapeutic opportunities

Poly (ADP-ribose) polymerase-1 (PARP-1) is the most extensively studied member of the PARP superfamily, with its primary function being the facilitation of DNA damage repair processes. Parthanatos is a type of regulated cell death cascade initiated by PARP-1 hyperactivation, which involves multiple...

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Bibliographic Details
Main Authors: Xiaoxue Xu, Bowen Sun, Chuansheng Zhao
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Neurobiology of Disease
Subjects:
PARP-1
parthanatos
PARP-1 inhibitors
neuroinflammation
oxidative stress
cell death
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123003303

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