Effect of giving probiotic supplement Lactobacillus acidophilus La-14 as an immunomodulator to maintain a respiratory system in Mus musculus
Background and Objectives: In 2020 the whole world is experiencing a pandemic condition due to infection with the SARS-CoV-2 virus which can cause the COVID-19 disease. This condition results in “Panic Buying”, because everyone tries to avoid the spread and transmission of the COVID-19 disease by do...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2021-06-01
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| Series: | Iranian Journal of Microbiology |
| Subjects: | |
| Online Access: | https://ijm.tums.ac.ir/index.php/ijm/article/view/2971 |
| _version_ | 1819007054934704128 |
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| author | Dita Artanti Yeti Eka Sispita Sari Fitrotin Azizah Nur Vita Puwaningsih Vella Rohmayani Dede Nasrullah |
| author_facet | Dita Artanti Yeti Eka Sispita Sari Fitrotin Azizah Nur Vita Puwaningsih Vella Rohmayani Dede Nasrullah |
| author_sort | Dita Artanti |
| collection | DOAJ |
| description | Background and Objectives: In 2020 the whole world is experiencing a pandemic condition due to infection with the SARS-CoV-2 virus which can cause the COVID-19 disease. This condition results in “Panic Buying”, because everyone tries to avoid the spread and transmission of the COVID-19 disease by doing various ways, one of which is by taking additional supplements such as vitamin C and probiotic supplements.
Materials and Methods: The materials used were mice Mus musculus male DDY strain aged 1-2 months. Probiotic supplement Lactobacillus acidophilus La-14 with a viability of 1 × 108 CFU/ml. with a weight of 0.16 grams dissolved in 0.25 ml 0.9% NaCl. Vitamin C used is a commercial vitamin C tablet, weighing 0.06 grams in 0.25 ml 0.9% NaCl. Meanwhile, the feed for mice (Mus musculus) is a complete feed from Pokphand with the code BR1 CP511B. Lung histology preparations data were analysed descriptively and statistically through the test Chi square while the data on the number of lymphocytes were analysed descriptively.
Results: The histological observations of lungs of Mus musculus showed that in the treatment of ML, MV, and MKA test was carried out chi square ratio between the groups that did not have lymphocyte infiltration and those that had lymphocyte infiltration showed a significant difference (p <0.05). Meanwhile, the results of the lymphocyte count showed that ML and MV treatment was higher than that of MK treatment.
Conclusion: It is suggested that the administration of probiotics can stimulate and modulate the respiratory immune system. |
| first_indexed | 2024-12-21T00:18:29Z |
| format | Article |
| id | doaj.art-ffa595a6d11b43179268e52217a0e6c9 |
| institution | Directory Open Access Journal |
| issn | 2008-3289 2008-4447 |
| language | English |
| last_indexed | 2024-12-21T00:18:29Z |
| publishDate | 2021-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Microbiology |
| spelling | doaj.art-ffa595a6d11b43179268e52217a0e6c92022-12-21T19:22:09ZengTehran University of Medical SciencesIranian Journal of Microbiology2008-32892008-44472021-06-011333813882971Effect of giving probiotic supplement Lactobacillus acidophilus La-14 as an immunomodulator to maintain a respiratory system in Mus musculusDita Artanti0Yeti Eka Sispita Sari1Fitrotin Azizah2Nur Vita Puwaningsih3Vella Rohmayani4Dede Nasrullah5Departement of Microbiology, Faculty Health of Sciences, University Muhammadiyah of Surabaya, Surabaya, IndonesiaDepartement of Microbiology, Faculty Health of Sciences, University Muhammadiyah of Surabaya, Surabaya, IndonesiaDepartement of Microbiology, Faculty Health of Sciences, University Muhammadiyah of Surabaya, Surabaya, IndonesiaDepartement of Clinical Pathology, Faculty Health of Sciences, University Muhammadiyah of Surabaya, Surabaya, IndonesiaDepartement of Microbiology, Faculty Health of Sciences, University Muhammadiyah of Surabaya, Surabaya, IndonesiaDepartement of Nursing, Faculty Health of Sciences, University Muhammadiyah of Surabaya, Surabaya, IndonesiaBackground and Objectives: In 2020 the whole world is experiencing a pandemic condition due to infection with the SARS-CoV-2 virus which can cause the COVID-19 disease. This condition results in “Panic Buying”, because everyone tries to avoid the spread and transmission of the COVID-19 disease by doing various ways, one of which is by taking additional supplements such as vitamin C and probiotic supplements. Materials and Methods: The materials used were mice Mus musculus male DDY strain aged 1-2 months. Probiotic supplement Lactobacillus acidophilus La-14 with a viability of 1 × 108 CFU/ml. with a weight of 0.16 grams dissolved in 0.25 ml 0.9% NaCl. Vitamin C used is a commercial vitamin C tablet, weighing 0.06 grams in 0.25 ml 0.9% NaCl. Meanwhile, the feed for mice (Mus musculus) is a complete feed from Pokphand with the code BR1 CP511B. Lung histology preparations data were analysed descriptively and statistically through the test Chi square while the data on the number of lymphocytes were analysed descriptively. Results: The histological observations of lungs of Mus musculus showed that in the treatment of ML, MV, and MKA test was carried out chi square ratio between the groups that did not have lymphocyte infiltration and those that had lymphocyte infiltration showed a significant difference (p <0.05). Meanwhile, the results of the lymphocyte count showed that ML and MV treatment was higher than that of MK treatment. Conclusion: It is suggested that the administration of probiotics can stimulate and modulate the respiratory immune system.https://ijm.tums.ac.ir/index.php/ijm/article/view/2971lactobacillus acidophilus;vitamin c;lymphocyte infiltration;lymphocytes;mus musculus |
| spellingShingle | Dita Artanti Yeti Eka Sispita Sari Fitrotin Azizah Nur Vita Puwaningsih Vella Rohmayani Dede Nasrullah Effect of giving probiotic supplement Lactobacillus acidophilus La-14 as an immunomodulator to maintain a respiratory system in Mus musculus Iranian Journal of Microbiology lactobacillus acidophilus; vitamin c; lymphocyte infiltration; lymphocytes; mus musculus |
| title | Effect of giving probiotic supplement Lactobacillus acidophilus La-14 as an immunomodulator to maintain a respiratory system in Mus musculus |
| title_full | Effect of giving probiotic supplement Lactobacillus acidophilus La-14 as an immunomodulator to maintain a respiratory system in Mus musculus |
| title_fullStr | Effect of giving probiotic supplement Lactobacillus acidophilus La-14 as an immunomodulator to maintain a respiratory system in Mus musculus |
| title_full_unstemmed | Effect of giving probiotic supplement Lactobacillus acidophilus La-14 as an immunomodulator to maintain a respiratory system in Mus musculus |
| title_short | Effect of giving probiotic supplement Lactobacillus acidophilus La-14 as an immunomodulator to maintain a respiratory system in Mus musculus |
| title_sort | effect of giving probiotic supplement lactobacillus acidophilus la 14 as an immunomodulator to maintain a respiratory system in mus musculus |
| topic | lactobacillus acidophilus; vitamin c; lymphocyte infiltration; lymphocytes; mus musculus |
| url | https://ijm.tums.ac.ir/index.php/ijm/article/view/2971 |
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